Objective: To observe the effect of VIP or SST on the lymphocyte homing to the intestinal tract. Methods: Intestinal lymph were collected from mesenteric lymphatic duct of rats. Intestinal lymphocytes, which had been incubated with VIP or SST, were labeled with 51Cr and then were infused into blood circulation of rats. The 51Cr-intestinal lymphocytes in organs (or tissues)were determined with γ-counter. Results: About 10% of 51Cr-intestinal lymphocytes homed to intestinal tract within 1 h at normal physiological state. The distribution of 51Cr-intestinal lymphocytes treated with either VIP or SST in mesenteric node (1.83% or1.56%) and in Peyer's patches (1.85% or 1.60%) were significantly lower than that of control group (3.83%, 3.85%), P<0.05. VIP or SST did not show remarkable affection on the homing of 51Cr-intestinal lymphocytes to diffusive lymphatic tissue in small intestine when compared with control. Conclusion: Either VIP or SST reduces the homing of intestinal lymphocytes to mesenteric nodes and Peyer's patches in rats.