Objective: To study the effect of somatostatin analogue octreotide on the invasion and metastasis of gastric cancer in vitro and in vivo. Methods: Using membrane invasion culture system alone or coated with matrigel, we observed the effect of octreotide on blocking migration and invasion of gastric carcinoma cells. Nude mice implanted orthotopically with SGC-7901 human stomach carcinoma were given injections of octreotide for 8 weeks. MMP-2 was detected by gelatin zymography or RT-PCR. The microvascular density and VEGF expression were examined by immunohistochemical staining with factor VIII antibody and VEGF antibody. Results: Octreotide significantly inhibit migration(49.8