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期刊论文
Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism
PNAS February 13, 2001, vol.98 no.4, 1841-1846,-0001,():
Hepatotropism is a prominent feature of hepatitis B virus (HBV) infection. Cell lines of nonhepatic origin do not independently support HBV replication. Here, we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor a plus peroxisome proliferator-activated receptor a, support HBV replication in nonhepatic cells by controlling pregenomic RNA synthesis, indicating these liver-enriched transcription factors control a unique molecular switch restricting viral tropism. In contrast, hepatocyte nuclear factor 3 antagonizes nuclear hormone receptormediated viral replication, demonstrating distinct regulatory roles for these liver-enriched transcription factors.
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