The authors developed an efficient biomimetic process to fabricate inorganic/organic nanocomposites with clay nano-platelets being the mineral and polyimide being the organic constituency. Samples with thickness of 10-200 μm were produced in a very short time using a centrifugal deposition process. This process resulted in an ordered nanostructure with alternating organic and inorganic layers. The mechanical properties were comparable to that of lamella bones, with a tensile strength of 70-80 MPa, Young's modulus of 8-9 GPa and hardness of about 1-2 GPa. The composite films could be lifted from the substrate and stacked to form bulk material for biomedical applications such as bioactive dental materials or bone replacements. This approach represents a milestone in the development of bulk-form layered inorganic/organic nanocomposites.