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期刊论文
Intervention and Follow-up on Human Esophageal Precancerous Lesions in Henan, Northern China, a High-Incidence Area for Esophageal Cancer
Vol. 29: Supplement 1, February, 2002,-0001,():
dies with calcium and decaffeinated green tea (DGT). Each group included 200 subjects (100 sub-jects for treatment, and 100 subjects of placebo). In calcium group, each subject received and oral supplementation of 1, 200mg of calcium daily for 11 months. In DGT group, each subject received 5mg of DGT daily for 12 months. In placebo group, each subject received placebo pill for 11 months (calciurn group) and 12 month (DGT group). At the entry and end trial, esophagecal biopsy specimens were taken at the middle and the lower thirds of the esophagus and from macroscopic iesions, if only, of each subject. Resulet: DGT trail did not show apparent difference between the treatment and placebo group in alleviatin the esophageal precancerous lesions and abnormal cell proliferation. For the calcium intervention study, after 11 years'follow-up. 10 subjects had developed into can-cers in the calcium group (10%, 8 EC and 2GCA), and 8 subjects developed into EC in the placebo group (8%). All these patients were diagnosed at very early stage of cancer (symptom-free). Of the 578 subjects, 25 (18 males and 7 females) had developed into EC (n=23, 43%) and gastric cardia cancer (GCA, n=2, 0.3%), during the 11 years'follow-up. The mean time of cancer development (from entry of the follow-up strdy to the detection) was 5.0±2.9 years (males) and 4.7±3.2 years (females). Of the 25 patients with EC and GCA, 11 were from the 387 followed subject with "normal" histomorphology of biopsy at the entry of the follow-up study (3%, 11/387), 2 were from the subjects with basal cell hyperpla-sia, grade 1 (BCH1, 2%, 2/94), 7 from the subjects with BCH grade Ⅱ (BCHⅡ, 10%, 7/72), and 5 from BCH Ⅲ and dysplasia (20%, 5/25). Conclusions: DGT trail was not shown to have beneficial effects in alleviation esophageal precancerous was not shown to have beneficial effects in alleviating esophageal precancerous le-sions and abnormal cell proliferation patterns. Calcium supplementation did not produce apparent long-term effects on EC. BCH Ⅱ could be considered as precan-cerous lesions of EC. The quantitative histopathological analysis in terms of num-ber of proliferating basal cell layers is importance in determining the high-risk subjects for EC and evaluating the intervention results. Follow-up studies with repeated endoscopic biopsies are the powerful strategy for early detection and mortality control of EC and GAC in the high incidence area.
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