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王晓民
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Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation
Journal of Neuroimmunology 148(2004)24-31，-0001，（）：
Mounting lines of evidence have suggested that brain inflammation participates in the pathogenesis of Parkinson's disease. Triptolide is oneof the major active components of Chinese herb Tripterygium wilfordii Hook F, which possesses potent anti-inflammatory andimmunosuppressive properties. We found that triptolide concentration-dependently attenuated the lipopolysaccharide (LPS)-induced decreasein [3H]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary mesencephalic neuron/glia mixed culture.Triptolide also blocked LPS-induced activation of microglia and excessive production of TNFa and NO. Our data suggests that triptolide mayprotect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia activation may underlie the mechanism.D 2003 Elsevier B.V. All rights reserved.
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