您当前所在位置: 首页 > 学者

王修杰

  • 6浏览

  • 0点赞

  • 0收藏

  • 0分享

  • 319下载

  • 0评论

  • 引用

期刊论文

Potential anticancer activity of litchi fruit pericarp extract against hepatocellular carcinoma in vitro and in vivo

王修杰Xiujie Wang a* Yuquan Wei a Shulan Yuan a Guanjian Liu b Yanrong Lu Jie Zhang a Wendong Wang c

Cancer Letters 239(2006)144-150,-0001,():

URL:

摘要/描述

Litchi fruit pericarp (LFP) extract contains significant amounts of polyphenolic compounds, and exhibits powerful antioxidative activity against fat oxidation in vitro. The purpose of this study is to confirm the anticancer activity of LFP extract against hepatocellular carcinoma in vitro and in vivo, and to elucidate the mechanism of its activity. Human hepatocellular carcinoma cell line was tested in vitro for cytotoxicity, colony formation inhibition, and cell cycle distribution through flow cytometry after treatment with water-soluble crude ethanolic extract (CEE) from LFP. Murine hepatoma bearing-mice were fed doses of 0.15, 0.3, and 0.6 g/kg/day of water-soluble CEE in DH2O p.o. for 10 days, respectively, to test the anticancer activity and BrdU incorporation of cancer cells in vivo. LFP extract demonstrated a dose- and time-dependent inhibitory effect on cancer cell growth; IC50 was 80 mg/ml, and significantly inhibited colony formation in vitro, tumor growth and BrdU incorporation into cancer cells in vivo. The tumor inhibitory rates at doses of 0.15, 0.3, and 0.6 g/kg/day were 17.31% (PO0.05), 30.77% (P!0.05), and 44.23% (P!0.01), respectively. BrdU labeled tumor cells of treated animals were 11.80G2.79%, and were significantly lower than that in untreated controls (23.00G5.42%, P!0.05). Our findings showed that LFP extract exhibited potential anticancer activity against hepatocellular carcinoma in vitro and in vivo through proliferating inhibition and apoptosis induction of cancer cells.

【免责声明】以下全部内容由[王修杰]上传于[2011年05月27日 09时10分54秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

我要评论

全部评论 0

本学者其他成果

    同领域成果