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期刊论文
Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo
nature immunology • volume 3 no 9 • september 2002，-0001，（）：
We studied here the long-term maintenance of distinct populations of T helper type 1 (TH1)-lineage cells in vivo and found that effector TH1 cells, defined by their secretion of interferon-γ (IFN-γ), are short-lived and do not efficiently develop into long-term memory TH1 cells. In contrast, a population of activated TH1-lineage cells that did not secrete IFN-γ after primary antigenic stimulation persistedfor several months in vivo and developed the capacity to secrete IFN-γ upon subsequent stimulation.These data suggest that a linear differentiation pathway, as defined by the transition from IFN-γ-producing to resting memory cells, is relatively limited in vivo and support a revised model for TH1memory differentiation.
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