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期刊论文
Prolongation of Rat Intestinal Allograft Survival by Administration of Donor Interleukin-12 p35-Silenced Bone Marrow–Derived Dendritic Cells
Transplantation Proceedings, 38, 1561-1563 (2006)，-0001，（）：
Severe graft rejection remains an important obstacle in intestinal transplantation. In this study, we demonstrated that intravenous injection of interleukin (IL)-12 p 35 siRNA-transfected dendritic cells (DCs) into recipient rats prolonged the survival of intestinal allografts. Serum IL-2 and interferon-γ levels in the IL-12 p35 siRNA-transfected DCs treatment group were both significantly lower than in control groups at 7 days after transplantation. Further study is required to investigate the operative pathways and to optimize the strategy targeting dendritic cells to induce tolerance to intestinal allografts.
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