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期刊论文
Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization
Cancer Genetics and Cytogenetics 123(2000)27-34,-0001,():
Comparative genomic hybridization (CGH) has been applied to detect recurrent chromosome al-terations in 62 primary gastric carcinomas. Several nomandom chromosomal changes, including gains of 8q (31 cases, 50%), 20q (29 cases, 47%) with a minimum gain region at 20q11.2 q12,13q (21 cases, 34%) with a minimum gain region at 13q22, and 3q (19 cases, 31%) were commonly ob-served. The regions most frequently lost included: 19p (23 cases, 37%), 17p (21 cases, 33%), and lp (14 cases, 23%). High copy number gain (DNA sequence amplification) was detected in 6 cases. Amplification of 8@3<124.2 and 20q11.2 q12 were observed in 3 cases. Gain of 20q and loss of 19p were confirmed by fluorescence in situ hybridization using corresponding bacterial artificial chromosomes (BAC) clones fiom those regions. The gain and loss of chromosomal regions idenfl-fled in this study provide candidate regions involved in gastric tumorigenesis.
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