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期刊论文
Role of fascin in the proliferation and invasiveness ofesophageal carcinoma cellsq
Biochemical and Biophysical Research Communications 337(2005)355-362，-0001，（）：
Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility in various transformed cells. The overexpressionof fascin in esophageal squamous cell carcinoma (ESCC) has been described only recently, but the roles and mechanism stillremained unclear. Here, by using RNA interference (RNAi), we have stably silenced the expression of the fascin in EC109 cells, an ESCCcell line. Down-regulation of fascin resulted in a suppression of cell proliferation and as well as a decrease in cell invasiveness. Furthermore,we revealed that fascin might have functions in regulating tumor growth in vivo. The effect of fascin on cell invasiveness correlatedwith the activation of matrix metalloproteases such as MMP-2 and MMP-9. We examined that fascin down-expression also led to adecrease of c-erbB-2 and b-catenin at the protein level. These results suggested that fascin might play crucial roles in regulating neoplasmprogression of ESCC.
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