Effects of Dachengqi Decoction (大承气汤) and Rhubarb on Cellular Electrical Activity in the Smooth Muscle of Guinea-Pig Taenia Coil*
CJIM 1995; 1 (1): 56-58，-0001，（）：
The effects of Daehengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellular electrical activities of guinea pig taenia coU have been studied by intracellular microelectrode technique. DCQ and Rb both improve the depolarization of cell membrane, speed up the burst of slow wave and spike potentials (when the drug concentration was 1%, P>0.05, 10% or 20%, P<0.03), which were dose de pendent. At the same concentration the effects of Rb were more significant than those of DCQ. These results suggest DCQ and Rb directly enhance the cellular electrical excitability so as to strengthen the con traction of the colon, is one of the mechanisms of the purgative action of these drugs at the cellular level. The ionic basis of the effects might be that DCQ and Rb reduce the K+ conductance of the cell membranes in a resting state.
版权说明：以下全部内容由杨文修上传于 2005年02月25日 19时26分29秒，版权归本人所有。