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Microinjection of bicuculline into the central nucleus of the amygdala: alters gustatory responses of the rat parabrachial nucleus
Brain Research 1028(2004)39-47,-0001,():
The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly: projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the: GABA receptors within the CeA are involved in this modulation, the effects of microinjection of bicuculline, a GABAA-selective antagonist,: into the CeA on the activities of PBN taste neurons were observed by using extracellular recording technique. In general, after bicuculline: was administered to ipsilateral CeA, the responses of PBN neurons to four tastants all inceased, with the magnitudes significantly higher: than those obtained before drug administration ( Pb0.01), respectively. However, after bicuculline was delivered into the contralateral CeA,: only the responses to NaCl, HCl and QHCl increased. According to the best-stimulus category, 47% NaCl-best (8/17), 64% HCl-best (7/11),: 80% QHCl-best (4/5), and 33% sucrose-best (1/3) increased their responses to at least one basic taste stimulus after GABAA receptors within: the ipsilateral CeA were blocked. After contralteral CeA injection, more NaCl-best neurons (6/8) increased responses than that after ipsilateral: CeA injection, but other best-stimulus units showed no differences before and after drug injection into the contralateral CeA. Analyses of: across-unit patterns indicated that the correlation coefficient of responses between NaCl and sucrose was apparently higher after drug: administration to the CeA. However, after drug injection into the contralateral CeA, the correlations between NaCl and the other three tastants: were higher than those before. These results indicate that the GABAA receptors within the CeA play an important role in modulating the: gustatory activities of PBN neurons.
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