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期刊论文

Antioxidant Activities and Antitumor Screening of Extracts from Cranberry Fruit (Vaccinium macrocarpon)

严小军XIAOJUN YAN BRIAN T. MURPHY GERALD B. HAMMOND JOE A. VINSON§ AND CATHERINE C. NETO*

J. Agric. Food Chem. 2002, 50, 5844-5849,-0001,():

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摘要/描述

ng seven tumor cell lines. Selective inhibition of K562 and HT-29 cells was observed from a methanolic extract in the range of 16-125 μg/mL. Radicalscavenging activity was greatest in an extract composed primarily of flavonol glycosides. Seven flavonol glycosides were isolated and purified from whole fruit for further evaluation; the anthocyanin cyanidin 3-galactoside was also purified for comparison with the flavonoids. Three flavonol monoglycosides were newly identified by 13C NMR as myricetin 3-α-arabinofuranoside, quercetin 3-xyloside, and 3-methoxyquercetin 3-β-galactoside (isorhamnetin); the other four isolated were the previously identified myricetin 3-β-galactoside, quercetin 3-β-galactoside, quercetin 3-α-arabinofuranoside, and quercetin 3-α-rhamnopyranoside. These compounds were evaluated for 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity and ability to inhibit low-density lipoprotein oxidation in vitro. Most of the flavonol glycosides showed antioxidant activity comparable or superior to that of vitamin E; cyanidin 3-galactoside showed activity superior to that of the flavonoids as well as vitamin E or Trolox in both antioxidant assays.

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