As the key equipment in the gas-liquid multiphase mixed transportation technique, the multiphase rotodynamic pump has been the focus of people’s concern. But the design of such a pump is formidable and challenging because it should simultaneously have the characteristics of a pump and a compressor. In this paper, based on the Navier-Stokes equations and the k–ε turbulent model, the 3-D turbulent flow in a multiphase rotodynamic pump impeller has been simulated numerically by using the SIMPLEC algorithm in body-fitted coordinates with the staggered grid system. The results show that the vortex region mainly exists near the tip of the impeller and the centrifugal force is an important factor to affect the formation of vortex flow that will lead to the hydraulic loss and efficiency decrease.