The noise model based on σ trous wavelet algorithm produces a multi-scale expression of image through the combination of wavelet transform and a testing model of statistical significance. This kind of expression not only gives the formation and location of image structure on different scales, but also eliminates the influence of noise. Since the algorithm does not need any priori hypotheses, it is suitable for the data with complex structure. The research line is employed in this paper to analyze the spatial activity of earthquake. The method of how to recognize and describe the multi-scale space activity of earthquake is emphatically discussed in this paper. Taking typical sequences in Southwest China as research cases, we systematically study the structure characters of spatial activity of earthquake on different scales. Results show that multi-scale space structure to some extent possesses indicative effect on strong epicenters. And the foreshock anomalies of Songpan seismic sequence also reveal interesting pattern during the spatial-temporal evolvement.