In this paper, we review some mafor progrosses made in the field of biomedical materials research on the application of collagen protein and its composites formed with certain synthetic polymers (e. g., polyhydroxvethyl methacrylate and polyvinyl alcohol). Some potential development and application of the materials are discussed tentatively. Due to their biocompatibility and physico-chemical properties, the collagen-synthetic polymer hydrogels will find wide application in soft tissue substitution, drug release system, guided tissue regeneration, and tissue engineering.