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张岫美

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期刊论文

Effects of Scutellarin on Apoptosis Induced by Cobalt Chloride in PC12 Cells

张岫美Li-Xiang Wang* Ji-Ping Zeng* Xin-Bing Wei Fu-Wu Wang Zhao-Ping Liu and Xiu-Mei Zhang

Chinese Journal of Physiology 50(6): 301-307, 2007,-0001,():

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摘要/描述

The present study investigated the protective effects of scutellarin on cobalt chloride (CoCl2)- induced apoptosis in PC12 cells. Incubation of PC12 cells with 500 μM CoCl2 for 24 h resulted in significant apoptosis as evaluated by the crystal violet, electron microscopy and flow cytometry assays. The increase of caspase-3 activity, decrease of Bcl-XL expression, phosphorylation of p38 mitogenactivated protein kinase (MAPK) and accumulation of intracellular reactive oxygen species (ROS) were also seen in CoCl2-treated PC12 cells. Scutellarin at 0.1, 1 and 10 μM significantly protected against the apoptotic cell death induced by CoCl2. Scutellarin decreased caspase-3 activity, increased Bcl-XL expression, inhibited p38 phosphorylation and attenuated ROS production. These results demonstrate that scutellarin can protect PC12 cells from cobalt chloride induced apoptosis by scavenging ROS, inhibiting p38 phosphorylation, up-regulating Bcl-XL expression and decreasing caspase-3 activity, and may reduce the cellular damage in pathological conditions associated with hypoxia-mediated neuronal injury.

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