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张学

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期刊论文

Identi

张学Hensin Tsao Xue Zhang Eric Benoit and Frank G Haluska

Oncogene (1998) 16, 3397-3402,-0001,():

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摘要/描述

A novel tumor suppressor gene, PTEN/MMAC1, has been recently shown to be mutated in gliomas, breast, prostate, kidney cancers and melanomas. Loss-of-heterozygosity studies in melanoma have suggested the presence of at least one chromosome 10q locus lost early in tumor progression. In this study, we screened 45 melanoma cell lines and 17 paired uncultured metastatic melanoma and peripheral blood specimens for PTEN/MMAC1 alterations using PCR-SSCP and direct sequencing. We found nine melanoma cell lines with homozygous deletions (

关键词: cancer genetics mutation PTEN/ MMAC1 melanoma

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