您当前所在位置: 首页 > 学者

张雅洁

  • 4浏览

  • 0点赞

  • 0收藏

  • 0分享

  • 45下载

  • 0评论

  • 引用

期刊论文

VEGF. A和VEGF. C在乳腺癌组织中的表达及其意义

张雅洁HU Shuai-Er.ZHANG Ya-Jie CUl Yu Mei ZHANG Hui-Qiu

《癌症》,2005,24(9):1076-1079,-0001,():

URL:

摘要/描述

BACKGRoUND&oBJECTlVE: Vascular endothelial growth factor (VEGF) famify is related to angiogenesis. VEGF-A and VEGF-C are closely related to tumorigenesis and lymphatic metastasis. This study was to detect the expression of VEGF-A and VEGF-C in breast cancer. and explore their correlation to celI proliferation, microvessel density (MVD), and lymphatic metastasis of breast cancer.METHODS:The expression of VEGF-A, VEGF-C, proliferating cell nuclear antigen (PCNA), and CD34 in 98 samples of breast cancer were detected by SP immunohistochemistry. RESULTS: The positive rate of VEGF-A was 85.7%: that of VEGF.C was 90.8% The positive rates of VEGF-A and VEGF-C were significantly higher in cancers with lymph node metastasis than in cancers without lymph node metastasis (P<0.05) The positive rate of PCNA was 98.O%: its expression level was increased with the expression levels of VEGF.A and VEGF-C f r=0.432, P=0.000; r=O.294, P=0.001) MVD was significantly higher in cancers with lymph node metastasis than in cancers without lymph node metastasis (64 26.26.40vs. 5O.29.29.35, P<0.05).MVD was positively correlated to the expression of VEGF-A (r=0.327. P<O O01), but had no correlation to VEGF-C (r=0.123,P>O.O5).C0NCLUSIONS:VEGF-A mainly mediates angiogenesis, cell proliferation, and metastasis of human breast cancer. VEGF-C promotes celI proliferation of human breast cancer: it is correlated to lymph node metastasis,but has no correlation to MVD.

【免责声明】以下全部内容由[张雅洁]上传于[2009年10月21日 09时29分47秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

我要评论

全部评论 0

本学者其他成果

    同领域成果