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期刊论文

Telomerase Activity in Gynecologic Tumors

郑鹏生PENG-SHENG ZHENG TSUYOSHI IWASAKA FUMIO YAMASAKI MAMORU OUCHIDA* MASATOSHI YOKOYAMA YOSHIFUMI NAKAO KOICHI FUKUDA TOSHITAKE MATSUYAMA AND HAJIME SUGIMORI

GYNECOLOGIC ONCOLOGY 64, 171-175 (1997),-0001,():

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摘要/描述

The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal ma-lignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas,condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with im-mortalization or malignant transformation of gynecologic tumors.

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版权说明:以下全部内容由郑鹏生上传于   2009年06月09日 14时02分21秒,版权归本人所有。

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