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期刊论文

Association of(S)- Isoserine Derivatives and 2, 2, 4- Trimethyl- 3- hydroxy- 4- cyclohexenecarboxylate

郑清川WANG Lei ZHENG Qing- chuan SONG Zhi- guang FANG Wei- shuo LI Ye- zhi HUANG Hua- min

CHEM. RES. CHINESE U. 2007, 23(1), 18- 21,-0001,():

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摘要/描述

Two novel compounds(4a and 4b) were obtained by the association of 2, 2, 4- trimethyl- 3- hydroxy- 5- cyclohexene- carboxylate with(S)- isoserine derivatives. The space location of the hydroxyl group of compound 1 was identified via the formation of lactone 6. Fe2(SO4)3·H2O was used as the catalyst for the synthesis of lactone 6. The carboxyl group was selectively protected with diazomethane. All the products were characterized via 1H NMR and mass spectra. The Docking study showed that the associations have the potential therapeutic use of DPP- Ⅳ inhibitor.

【免责声明】以下全部内容由[郑清川]上传于[2008年04月17日 10时53分36秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

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