In this article, an adaptive control approach–Adaptive Generic Model Control (AGMC) for a class of nonlinear time-varying processes with input time delay is proposed. First, a nonlinear state predictor (NSP) is introduced, which extends the conventional generic model control (GMC) to a class of nonlinear processes with input time delay. Then a class of nonlinear time-varying processes with input time delay is further considered. A modified strong tracking filter (MSTF) is adopted to estimate the timevarying parameters of the nonlinear processes, and the state estimates are then utilized to update the plant models used in the NSP and MSTF, this results in an adaptive generic model control scheme for a class of nonlinear time-varying processes with input time delay. A modified mathematical model of a three-tank-system is used for computer simulations, the results show that the proposed AGMC algorithm is satisfactory, and it has definite robustness against model/plant mismatch in the measurement noise.