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周宏灏
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期刊论文
Effect of the gene dosage of CYP2C19 on diazepam metabolism in Chinese subjects
CLINICAL PHARMACOLOGY & THERAPEUTICS DECEMBER 1999: 66: 642-6，-0001，（）：
Objective: To determine whether the gene dosage of CYP2C19 affects the metabolism of diazepam and desmethyldiazepam in healthy Chinese subjects. Subjects and methods: Eighteen unrelated adult men were recruited for the study from a total of 101 healthy Chinese volunteers who had been screened for CYP2C19 phenotype and genotype. All subjects received a single oral dose (5mg) of diazepam, and the pharmacokinetics of diazepam and desmethyldiazepam were compared in six m1 homozygotes (m1/m1), six m1 heterozygotes (wt/m1), and six wild-type homozygotes (wt/wt). Results: The plasma elimination half-life values of diazepam (84.0
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