提示
周宏灏
-
35浏览
-
0点赞
-
0收藏
-
0分享
-
233下载
-
0评论
-
引用
期刊论文
Assessment of cytochrome P450 activity by a five-drug cocktail approach
CLINICAL PHARMACOLOGY & THERAPEUTICS DECEMBER 2001; 70: 455-461，-0001，（）：
Objectives: Our goal was to establish and validate a modified cocktail approach including probe drugs caffeine, chlorzoxazone, mephenytoin, metoprolol, and midazolam for simultaneous phenotyping of CYP1A2, CYP2E1, CYP2C19, CYP2D6, and CYP3A. Methods: The study was conducted in 14 healthy, nonsmoking male volunteers with a cocktail of 5 drugs consisting of 100mg caffeine, 200mg chlorzoxazone, 100mg mephenytoin, 100mg metoprolol, and 7.5mg midazolam in a randomized manner with a 7
【免责声明】以下全部内容由[周宏灏]上传于[2005年01月19日 21时16分24秒]，版权归原创者所有。本文仅代表作者本人观点，与本网站无关。本网站对文中陈述、观点判断保持中立，不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。
本学者其他成果
同领域成果
