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Expression of platelet endothelial cell adhesion molecule-1 between pancreatic lmcrocirculation and peripheral circulation in rats with acute edematous pancreatitis
Hepatobiliary & Pancreatic Diseases International, Vol 2, No 3, 463-466,-0001,():
OBJECTIVE: To study the changes of platelet endothelial cell adhesion molecule-1 (PECAM-1) expression on polymorphonuclear leukocytes (PMNs) in peripheral circulation and pancreatic microeirculation in rats with acute edematous pancreatitis (AEP). METHODS: The model of AEP was established with 50 Wistar rats, and the changes of PECAM-1 expression on PMNs from the splenic vein and inferior vena cava were determined by flow cytometry. RESULTS: PECAM-1 expression on PMNs showed no significant difference between pancreatic microcireulation and peripheral circulation at AEP2h and AEP4h time points. From the AEP4h to the AEP8h time point, PECAM-1 expression in peripheral circulation was up-regulated, but PECAM-1 expression in pancreatic microcirculation was down-regulated. PECAM-1 expression had a significant difference between pancreatic mierocirculation and peripheral circulation at the AEPSh time point (P<0.05). CONCLUSION: PECAM-1 expression on PMNs is in a converse way between pancreatic microcirculation and peripheral circulation in AEP.
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