李金恒
主要兴趣包括有机化学方法学,金属有机化学和绿色化学。具体研究方向为过渡金属催化偶联反应、炔烃卤钯化反应、不活泼的C-H键活化反应、纳米催化剂的合成及在有机合成中应用、抗肿瘤靶向药物合成新方法研究、发展包括绿色介质和无溶剂反应等在内的绿色化学等。
个性化签名
- 姓名:李金恒
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
-
学科领域:
应用化学(具体应用入有关学科)
- 研究兴趣:主要兴趣包括有机化学方法学,金属有机化学和绿色化学。具体研究方向为过渡金属催化偶联反应、炔烃卤钯化反应、不活泼的C-H键活化反应、纳米催化剂的合成及在有机合成中应用、抗肿瘤靶向药物合成新方法研究、发展包括绿色介质和无溶剂反应等在内的绿色化学等。
李金恒,教授,1971年生。2001年9年进入湖南师范大学化学化工学院工作,2002年晋升教授,2003年遴选为有机化学博士生导师。先后于湖南师范大学、中国科学院广州化学研究所、中国科技大学完成本科、硕士和博士阶段的学习和研究工作。博士毕业后在香港大学进行博士后研究。主要兴趣包括有机化学方法学,金属有机化学和绿色化学。具体研究方向为过渡金属催化偶联反应、炔烃卤钯化反应、不活泼的C-H键活化反应、纳米催化剂的合成及在有机合成中应用、抗肿瘤靶向药物合成新方法研究、发展包括绿色介质和无溶剂反应等在内的绿色化学等。目前已承担主持科研项目10余项,在研项目8项,其中包括国家自然科学基金和湖南省杰出青年基金,并入选了2006年教育部新世纪优秀人才支持计划。已在Org. Lett.、J. Org. Chem.等国内外重要刊物上发表论文100余篇,被同行在SCI收录论文和国际出版专著中引用300多次。
-
主页访问
3283
-
关注数
0
-
成果阅读
804
-
成果数
16
【期刊论文】Efficient Stille Cross-Coupling Reaction Catalyzed by the Pd(OAc)2/Dabco Catalytic System
李金恒, Jin-Heng Li, Yun Liang, De-Ping Wang, Wen-Jie Liu, Ye-Xiang Xie, and Du-Lin Yin
J. Org. Chem. 2005, 70, 2832-2834,-0001,():
-1年11月30日
An efficient Pd(OAc)2/Dabco-catalyzed Stille cross-coupling reaction procedure has been developed. In the presence of Pd(OAc)2 and Dabco (triethylenediamine), various aryl halides including aryl iodides, aryl bromides, and activated aryl chlorides were coupled efficiently with organotin compounds to afford the corresponding biaryls, alkene, and alkynes in good to excellent yields. Furthermore, high TONs [turnover numbers, up to 980 000 TONs for the coupling reaction of 1-bromo-4-nitrobenzene and furan-2-yltributyltin] for the Stille cross-coupling reaction were observed.
-
29浏览
-
0点赞
-
0收藏
-
0分享
-
112下载
-
0评论
-
引用
李金恒, Jin-Heng Li, Shi Tang, and Ye-Xiang Xie
J. Org. Chem. 2005, 70, 477-479,-0001,():
-1年11月30日
A general and selective palladium-catalyzed carbonylation of terminal alkynes method for the synthesis of (Z)-3-haloacrylates is presented. In the presence of a catalytic amount of PdX2 and 5 equiv of CuX2 (X=Cl and Br), terminal alkynes were carbonylated to afford the corresponding (Z)-3-haloacrylates exclusively in moderate to good yields. The results showed that the effect of solvent had a fundamental influence on the chemoselectivity and stereoselectivity of the palladium-catalyzed carbonylation reaction.
-
34浏览
-
0点赞
-
0收藏
-
0分享
-
97下载
-
0评论
-
引用
李金恒, Jin-Heng Li, Wen-Jie Liu, and Ye-Xiang Xie
J. Org. Chem. 2005, 70, 5409-5412,-0001,():
-1年11月30日
A stable and efficient Pd(OAc)2/DABCO (triethylenediamine) catalytic system for Suzuki-Miyaura cross-coupling reaction has been developed. In the presence of Pd(OAc)2 and DABCO, coupling of aryl halides with arylboronic acids was carried out smoothly to afford good to excellent yields and high turnover numbers (TONs) (the maximal TONs were up to 960 000 for the reaction of 1-iodo-4-nitrobenzene with phenylboronic acid) using PEG-400 as the solvent. Moreover, the Pd(OAc)2/DABCO/PEG-400 system could be recycled and reused five times without any loss of catalytic activity for aryl iodides and bromides.
-
46浏览
-
0点赞
-
0收藏
-
0分享
-
109下载
-
0评论
-
引用
李金恒, Yun Liang, Ye-Xiang Xie, and Jin-Heng Li
J. Org. Chem. 2006, 71, 379-381,-0001,():
-1年11月30日
PdCl2(PPh3)2 combined with TBAF under solvent-free conditions provided general and fast Sonogashira cross-coupling reactions of aryl halides with terminal alkynes. In particular, this protocol could be applied to the reactions of deactivated aryl chlorides. In the presence of 3 mol % of PdCl2(PPh3)2 and 3 equiv of TBAF, a number of ArX species (X=I, Br, Cl) were coupled with alkynes to afford the corresponding products in moderate to excellent yields under copper-, amine-, and solvent-free conditions.
-
41浏览
-
0点赞
-
0收藏
-
0分享
-
132下载
-
0评论
-
引用
李金恒, Jin-Heng Li, Bo-Xiao Tang, Li-Ming Tao, Ye-Xiang Xie, Yun Liang, and Man-Bo Zhang
J. Org. Chem. 2006, 71, 7488-7490,-0001,():
-1年11月30日
A combination of Cu2O nanoparticles with P(o-tol)3 shows highly catalytic activity for the Stille cross-coupling reaction. A series of copper catalysts and ligands were evaluated, and Cu2O nanoparticles combined with P(o-tol)3 provided the best results. In the presence of Cu2O nanoparticles and P(o-tol)3, a variety of aryl halides including aryl chlorides underwent the Stille reaction with organotins smoothly in moderate to excellent yields using inexpensive TBAB (n-Bu4NBr) as the medium. It is noteworthy that the Cu2O/P(o-tol)3/TBAB system can be recovered and reused at least three times without any loss of catalytic activity among the reactions of aryl iodides and activated aryl bromides.
-
44浏览
-
0点赞
-
0收藏
-
0分享
-
138下载
-
0评论
-
引用
李金恒, Ye-Xiang Xie, Shao-Feng Pi, Jian Wang, Du-Lin Yin, and Jin-Heng Li
J. Org. Chem. 2006, 71, 8324-8327,-0001,():
-1年11月30日
Efficient and solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides have been demonstrated. In the presence of CuBr, 2-aminopyrimidine-4,6-diol, and TBAF (n-Bu4NF), a variety of imidazoles underwent the N-arylation reaction with aryl and heteroaryl halides smoothly in moderate to excellent yields. Noteworthy is that the reaction is conducted under solvent-free conditions.
-
33浏览
-
0点赞
-
0收藏
-
0分享
-
71下载
-
0评论
-
引用
李金恒, Jin-Heng Li, Ye-Xiang Xie, and Du-Lin Yin
J. Org. Chem. 2003, 68, 9867-9869,-0001,():
-1年11月30日
Carbon dioxide was found to promote the palladium-catalyzed zinc-mediated reductive Ullmann coupling of aryl halides. In the presence of carbon dioxide, Pd/C, and zinc, various aromatic halides including less reactive aromatic chlorides were coupled to give the corresponding homocoupling products in good yields.
-
29浏览
-
0点赞
-
0收藏
-
0分享
-
67下载
-
0评论
-
引用
李金恒, Jin-Heng Li, Yun Liang, and Ye-Xiang Xie
J. Org. Chem. 2004, 69, 8125-8127,-0001,():
-1年11月30日
A regioselective and stereoselective palladium-catalyzed dimerization of terminal alkynes method for the synthesis of symmetrical (Z,Z)-1,4-dihalo-1,3-dienes is presented. In the presence of a catalytic amount of PdX2 and 3 equiv of CuX2 (X=Cl and Br), terminal alkynes were dimerized to afford (Z,Z)-1,4-dihalo-1,3-dienes in good yields. The results showed that the effect of solvent had a fundamental influence on the chemoselectivity of the dimerization reaction. The mechanism of the palladium-catalyzed dimerization reaction is also discussed.
-
20浏览
-
0点赞
-
0收藏
-
0分享
-
53下载
-
0评论
-
引用
李金恒, Jin-Heng Li, Yun Liang, and Ye-Xiang Xie
J. Org. Chem. 2005, 70, 4393-4396,-0001,():
-1年11月30日
An efficient method for palladium-catalyzed homocoupling reaction of terminal alkynes in the synthesis of symmetric diynes is presented. The results showed that both Pd(OAc)2 and CuI played crucial roles in the reaction. In the presence of 2 mol % Pd(OAc)2, 2 mol % CuI, 3 equiv of Dabco, and air, homocoupling of various terminal alkynes afforded the corresponding symmetrical diynes in moderate to excellent yields, whereas low yields were obtained without either Pd(OAc)2 or CuI. Moreover, high TONs (turnover numbers; up to 940 000 for the reaction of phenylacetylene) for the homocoupling reaction were observed. Under similar reaction conditions, cross-coupling of 1-iodo-4-nitrobenzene with phenylacetylene was also carried out smoothly in quantitative yield. However, the presence of CuI disfavored the palladium-catalyzed Sonogashira cross-coupling reactions of the less active aryl iodides and bromides. In the presence of 0.01-2 mol % Pd(OAc)2, a number of aryl iodides and bromides were coupled with terminal alkynes in good to excellent yields. It is noteworthy that this protocol employs mild, efficient, aerobic, copper-free, and ligand-free conditions.
-
105浏览
-
0点赞
-
0收藏
-
0分享
-
93下载
-
0评论
-
引用
【期刊论文】Efficient and Reusable PdCl2(MeCN)2/CuCl2/PEG-400 System for Cyclization of Alkenyl
李金恒, Jin-Heng Li, Qi-Ming Zhu, Yun Liang, Dan Yang
J. Org. Chem. 2005, 70, 5347-5349,-0001,():
-1年11月30日
PEG-400 [poly (ethylene glycol-400)] was found as an effective medium for the PdCl2(MeCN)2-catalyzed hydroalkylation cyclization of alkenyl
-
39浏览
-
0点赞
-
0收藏
-
0分享
-
63下载
-
0评论
-
引用