陈国南
从事环境分析化学、光化学传感技术、化学发光、电致化学发光生物电化学及毛细管电泳等方面的研究,在电化学及化学发光理论、化学发光测试仪器的研制、高效化学发光试剂的合成、化学发光免疫分析及电致化学发光等方面都作了卓有成效的研究工作,取得了丰硕成果
个性化签名
- 姓名:陈国南
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学术头衔:
博士生导师
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学科领域:
分析化学
- 研究兴趣:从事环境分析化学、光化学传感技术、化学发光、电致化学发光生物电化学及毛细管电泳等方面的研究,在电化学及化学发光理论、化学发光测试仪器的研制、高效化学发光试剂的合成、化学发光免疫分析及电致化学发光等方面都作了卓有成效的研究工作,取得了丰硕成果
陈国南,教授,博士生导师。1982年福州大学化学系硕士研究生毕业,毕业后留校从事教学与科研工作。1986年底赴澳大利亚LA TROBE大学攻读博士学位,1990年获得博士学位后在墨尔本大学做博士后,1993年完成博士后研究,回福州大学工作。回国后一直从事环境分析化学、光化学传感技术、化学发光、电致化学发光生物电化学及毛细管电泳等方面的研究,在电化学及化学发光理论、化学发光测试仪器的研制、高效化学发光试剂的合成、化学发光免疫分析及电致化学发光等方面都作了卓有成效的研究工作,取得了丰硕成果。回国以来,陈国南教授在这些研究领域已经在国内外重要刊物上发表论文一百多篇,60多篇被SCI收录,其中绝大部分发表在国外著名刊物上,包括Anal. Chem.(美国分析化学杂志,影响因子=5.450)和Electrophoresis(国际电泳杂志,影响因子=4.325)等本学顶尖刊物,所发表的论文被国内外重要刊物引用300多次。陈国南教授出版的学术专著《化学发光与生物发光--理论及应用》获得1999年华东地区优秀科技图书一等奖。陈国南教授近年来还获得多项国家专利。回国后陈国南教授曾先后主持并完成了与海洋环境监测、环境分析化学、光化学传感技术、电致化学发光及毛细管电泳等有关的国家自然科学基金、国家"863"海洋监测技术主题、省自然科学基金、教育部科研基金等十几个项目,1998、2002和2004年分别获得福建省科学技术进步二等奖,2005年获得福建省科学技术进步一等奖(均为第一获奖者)。陈国南教授目前正致力于海洋环境监测技术、生物大分子的发光探针、毛细管电泳和电色谱、农药残留、天然药物有效成分及生物活性肽的分离检测等方面的研究,并取得了一批成果。目前应邀为Electrophoresis、Aanl. Chim. Acta、Talanta、Analytical Biochemistry、J. Separation science、J. Agricultural and Food Chemistry、Analytical and Bioanalytical Chemistry、J.of Prmaceutical and Biomedical Analysis、Biosensors & Bioelectronics 等国际著名杂志的特约审稿人。
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276
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成果数
7
陈国南, Guonan Chen, *, † Yuwu Chi, † Xiaoping Wu, † Jianping Duan, ‡ and Nianbin Li†
Anal. Chem. 75(2003)6602-6607,-0001,():
-1年11月30日
A system of capillary electrophoresis with electrochemiluminescence detection (CE-ECL) together with UV spectroscopic and electrochemical methods were used to study the chemical oxidation of p-hydroxyphenylpyruvic acid (pHPP) by dissolved oxygen in aqueous solution. The pHPP was observed to be readily oxidized by dissolved oxygen in alkaline solution and yielded a compound that strongly enhanced the electrochemiluminescence of Ru(bpy)2 3+. This compound was separated and detected by a new CE-ECL system and revealed to be oxalate by being compared with an authentic sample of oxalate. The chemical oxidation mechanism of pHPP by dissolved oxygen was discussed in this paper.
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陈国南, Lan Zhang a, b, Ping Tong a, Guonan Chenb, ∗
Journal of Chromatography A 1098(2005)194-198,-0001,():
-1年11月30日
Aesculetin is the product of the hydrolysis reaction of aesculin.Ahigh sensitivity and good repeatability method based on capillary electrophoresis with amperometric detection (CE-AD) was developed for simultaneous determination of aesculin and aesculetin in the hydrolysate of aesculin. Under the optimum condition: 10mmol/L KH2PO4–5 mmol/L Na2B4O7 (pH 6.0) buffer, separation at 18 kV and +900mV (versus Ag/AgCl) as the detection potential, the hydrolysis rate constants of aesculin hydrolysis at 25, 30, 35, 40 and 45℃ in 0.1 mol/L KOH were obtained as 1.45×10−2 min−1, 2.01×10−2 min−1, 2.93×10−2 min−1, 3.76×10−2 min−1 and 5.05×10−2 min−1, respectively. It was calculated that the activation energy for aesculin hydrolysis was 49.4 kJ/mol.
Capillary electrophoresis, Amperometric detection, Hydrolysis rate constant, Activation energy, Aesculin, Aesculetin
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陈国南, XUEQIN XU, † HONGZHI YE, ‡ WEI WANG, † AND GUONAN CHEN*, †
J. Agric. Food Chem. 53(2005)5853-5857,-0001,():
-1年11月30日
A capillary electrophoresis system coupled with wall-jet amperometric detection was used to determine five flavonoids (kaempferol, rutin, hyperoside, quercitrin, quercetin) in Herba Leonuri. Several important effect factors, such as the pH and concentration of running buffer, separation voltage, injection time, and detection potential, were investigated to acquire the optimum conditions. With 50 mmoL/L Na2B4O7-100 mmoL/L NaH2PO4 buffer (pH=7.50) as the running buffer, the five flavonoids were baseline separated within 15 min in a 60 cm length capillary at a separation voltage of 15 kV. The relationship between peak currents and analyte concentrations was linear over about 2 orders of magnitude, with detection limits (S/N=3) ranging from 0.03 to 0.08μg/mL for all analytes. The use of this method for the quantitation of the above flavonoids present in the real sample of Herba Leonuri was reported.
Flavonoids, capillary electrophoresis, amperometric detection, Herba leonuri
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陈国南, Yingying Su, Jian Wang, Guonan Chen∗
Analytica Chimica Acta 551(2005)79-84,-0001,():
-1年11月30日
The main aim of this paper is to explore a new label for electrochemiluminescence(ECL) bioassays. Tetra-substituted sulphonated cobalt(II) (CoTSPc)acting as a mimetic peroxidase ofhorseradish peroxidase was first found to be able to catalyze the ECL reaction of luminol-H2O2 at a glass carbon electrode. CoTSPc also retained its ECL catalytic activity when it was conjugated to BSA. Moreover, the enhanced ECL intensity of the luminol–H2O2 system at pH 7.4 was proportional to the amount of target bovine serum albumin (BSA). The spectrum characteristics of CoTSPc–BSA conjugate was examined. The effects of the pH, reaction medium of the solution, the concentration of luminal, H2O2 and the electrochemical scanning mode were also investigated. Although refinements in the technique are still necessary before it can be used in practice, a new ECL probe for protein, CoTSPc, has been preliminarily developed.
Electrochemiluminesence, Tetra-substituted sulphonated cobalt(, II), phthalocyanine, Bovine serum albumin
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陈国南, Lan Zhang, Yuanhuan Liu, Guonan Chen∗
Journal of Chromatography A 1043(2004)317-321,-0001,():
-1年11月30日
A rapid, easy and reproducible capillary electrophoresis (CE) method for the simultaneous determination of allantoin, choline and arginine in Rhizoma Dioscoreae was developed first time. Under the optimum condition, the three analytes could be well separated within 5 min in a 70 cm (60 cm effective length) ×75μmi.d. capillary. The relative standard deviations for both migration time and peak height were less than 3.20%. The linear response range was 5.0-150, 0.9-100 and 1.0-200μg/ml for arginine, choline and allantoin, respectively. The detection limit of three components was 2.0, 0.4 and 0.5g/ml for arginine, choline and allantoin, respectively. Contents of arginine, choline and allantoin in the crude drug of Rhizoma Dioscoreae could be easily determined by the proposed method with satisfactory results.
Rhizoma Dioscoreae, Pharmaceutical analysis, Allantoin, Choline, Arginine
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【期刊论文】A new porous plastic fiber probe for ammonia monitoring
陈国南, Zenghong Xie, Liangqia Guo, Xianghua Zheng, Xucong Lin, Guonan Chen∗
Sensors and Actuators B 104(2005)173-178,-0001,():
-1年11月30日
A novel porous plastic fiber probe was developed for detection of dissolved ammonia. This porous plastic fiber sensitive probe was prepared based on the co-polymerization technique. This novel porous fiber probe has been used for determination of dissolved ammonia in aqueous solution when Erythrosin A was used as the fluorescent indicator. The principle and preparation of this novel porous fiber probe were presented in details. The influences of polymer materials, the effects of pH and the properties of porous plastic fiber were also discussed. Experiments revealed that this fiber probe had an interconnected porous structure and high ammonia gas permeability and water impermeability. In aqueous solution, it was highly selective and stable to dissolved ammonia. The result shows that the probe responds to dissolved ammonia over the linear concentration range of 2.0×10−4-9.1×10−3mol l−1 and it is not influenced by pH in solution.
Ammonia, Porous plastic fiber, Probe
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【期刊论文】Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics
陈国南, Qiu Bin, Wang Wei, Yuwu Chi, Guonan Chen*
Analytical Biochemistry 336(2005)196-201,-0001,():
-1年11月30日
The electrochemical behaviors of diethylstilbestrol (DES) at a glassy carbon electrode were investigated by cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry (DPV). Based on these, a sensitive and selective DPV method was developed for determination of DES. The linear response range of DES is 1.0
Diethylstilbestrol, Electrochemistry, Pharmacokinetics
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