卓仁禧
生物医用高分子:包括生物可降解高分子、基因转染高分子载体、生物活性高分子、靶向性磁共振造影剂、固定化酶及其应用等
个性化签名
- 姓名:卓仁禧
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学术头衔:
博士生导师, 中国科学院院士
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学科领域:
高分子化学
- 研究兴趣:生物医用高分子:包括生物可降解高分子、基因转染高分子载体、生物活性高分子、靶向性磁共振造影剂、固定化酶及其应用等
高分子化学家。中国科学院院士。1953年复旦大学化学系毕业后到武汉大学化学系任教至今。1983年至1984年到美国耶鲁大学做访问学者,从事生物活性化合物的研究。
目前主要研究方向为生物医用高分子:包括生物可降解高分子、基因转染高分子载体、生物活性高分子、靶向性磁共振造影剂、固定化酶及其应用等。
发表论文320余篇,获得的国家级、省部级的主要奖项包括1999年国家自然科学三等奖,1991年国家自然科学四等奖,1999年国家教育部科技进步一等奖,1991年国家教育部科技进步一等奖,1983年国家科技发明三等奖和两项1978年全国科学大会奖。
担任中国生物材料委员会副主席、国际生物材料科学与工程学会会士(Fellow);任《Polymer International》执行编委、负责中国分编辑部事务;任《高分子学报》、《离子交换与吸附》和《Chinese Journal of Reactive Polymers》副主编,和《高等学校化学学报》、《Chinese Journal of Polymer Science》等杂志编委。
1960年和1987年先后当选湖北省劳动模范,1995年当选全国先进工作者。
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成果数
10
【期刊论文】Liver-targeting macromolecular MRI contrast agents
卓仁禧, YAN Guoping, ZHUO Renxi, XU Mianyi, LI Liyun & TANG Yuefeng
SCIENCE IN CHINA (Series B) Vol. 44 No.4 August 2001,-0001,():
-1年11月30日
ting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetriaminepentaacetic acid monopyridoxamine group (DTPA-PM) into poly-α, β-[N-(2-hydroxyethyl)-Laspartamide] (PHEA) and poly-α, β-[N-(2-aminoethyl)-L-aspartamide] (PAEA). The macromolecular ligands thus obtained were further complexed with gadolinium chloride to give macromolecular MRI contrast agents with different Gd() contents. These macromolecular ligands and their gadolinium complexes were characterized by 1H NMR, IR, UV and elementary analysis. Relaxivity studies showed that these polyaspartamide gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging of the liver in rats and experimental data of biodistribution in mice indicate that these macromolecular MRI contrast agents containing pyridoxamine exhibit liver-targeting property.
polyaspartamide,, gadolinium complexes,, magnetic resonance imaging (, MRI), ,, relaxivity,, liver-targeting.,
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卓仁禧, Jun Feng, Feng He, and Renxi Zhuo*
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-1年11月30日
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卓仁禧, Jian-Tao Zhang, Shi-Wen Huang, Ren-Xi Zhuo*
Macromol. Chem. Phys. 2004, 205, 107-113,-0001,():
-1年11月30日
hydrogels, phase separation, stimuli-sensitive polymers
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卓仁禧, Xu-Ye Wu, Shi-Wen Huang, Jian-Tao Zhang, Ren-Xi Zhuo*
Macromol. Biosci. 2004, 4, 71-75,-0001,():
-1年11月30日
biological applications of polymers, dendrimers, freezing-thawing, hydrogels, poly(, vinyl alcohol), (, PVA),
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卓仁禧, Xian-Zheng Zhang and Ren-Xi Zhuo*
Langmuir 2001, 17, 12-16,-0001,():
-1年11月30日
A gel is a water-insoluble polymeric material though it can absorb a lot of water in its network structure. The poly(N-isopropylacrylamide) (PNIPA) gel exhibits a change in volume in response to external temperature changes and this property is useful in many fields. In this manuscript, a novel PNIPA gel was synthesized by using ethylene triethoxy silane (ETEOS) as the cross-linking agent under acidic conditions. This siloxane incorporated PNIPA gel achieves a dramatically rapid response rate when the external temperature is changed. We suggest that the improvement of the response rate could be due to the macroporous structure of the produced polymer network during the polymerization/cross-linking process. This macroporous structure can provide interconnected water release channels and prevent the formation of a dense, thick skin layer at the shrinking course. On the other hand, water can also diffuse into the polymer network through these water channels during the reswelling process.
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卓仁禧, TAO PENG, SI-XUE CHENG, REN-XI ZHUO
Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 42, 1356-1361 (2004),-0001,():
-1年11月30日
biodegradable, graft copolymers, ring-opening polymerization
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卓仁禧, L. F. SUN, R. X. ZHUO, Z. L. LIU
Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 41, 2898-2904 (2003),-0001,():
-1年11月30日
Copolymers of 2-methylene-1,3-dioxepane (MDO) and methyl acrylate (MA) containing ester units both in the backbone and as pendant groups were synthesized by free-radical copolymerization. The influence of reaction conditions such as the polymerization time, temperature, initiator concentration, and comonomer feed ratio on the yield, molecular weight, and copolymer composition was investigated. The structure of the copolymers was confirmed by 1H NMR, 13C NMR, and IR spectroscopy. Differential scanning calorimetry indicated that the copolymers had a random structure. An NMR study showed that hydrogen transfer occurred during the copolymerization. The reactivity ratios of the comonomers were rMDO=0.0235 and rMA=26.535. The enzymatic degradation of the copolymers obtained was carried out in the presence of proteinase K or a crude enzyme extracted from earthworms. The experimental results showed that the higher ester molar percentage in the backbone caused a faster degradation rate.
2-methylene-1,, 3-dioxepane, methyl acrylate, ring-opening polymerization, biodegradable, proteinase K, enzymes
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【期刊论文】A Novel Method for the Preparation of Core-Shell Nanoparticles and Hollow Polymer Nanospheres
卓仁禧, Faquan Yu, , Yanping Liu, Renxi Zhuo
Journal of Applied Polymer Science, Vol. 91, 2594-2600 (2004),-0001,():
-1年11月30日
A one-step method to prepare core-shell nanoparticles and thus hollow nanospheres is reported. The process for the formation of core and shell took place during reaction. Once the core formed, it was covered with the shell substance produced in situ, and thus, the shell hindered the continued growth of the core. Based on this method, we readily obtained core-shell nanoparticles by choosing AgCl, CuS, or Fe(III) diethyldithiocarbamate (FeDEC)3 as model core substances and the cogel from gelatin and gum arabic as the shell substance. High-resolution transmission electron microscopy (HRTEM) directly revealed the core-shell structure. TEM results showed the average particle sizes were under 100 nm, depending on the core substance and the concentration of substances producing cores. After removal of the core materials, hollow nanospheres resulted, which were directly observed by TEM. The bservation further verified the core-shell structure. UV spectrophotometry also gave signals of coated structure and revealed high core content (51.1%) and nearly perfect coating (91.6%).
gelatin, gum arabic, core-shell structure, nanoparticle, hollow nanosphere
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卓仁禧, Xian-Zheng Zhang, Ren-Xi Zhuo*
European Polymer Journal 36(2000)643-645,-0001,():
-1年11月30日
Poly(N-isopropylacrylamide) (PNIPA) is a thermosensitive hydrogel and undergoes volume changes in response to external temperature changes. In some potential applications of PNIPA hydrogel, a fast response rate is needed. Here, a novel PNIPA hydrogel was synthesized by using water/actone (v/v, 1:1) as mixed solvent during the redox polymerization/crosslinking reaction. The characterization of this PNIPA hydrogel was gravimetrically measured, and it exhibits much faster deswelling rate than that of the normal-type PNIPA hydrogel.
Fast deswelling, Temperature-sensitive, PNIPA, Hydrogel
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卓仁禧, Shi-Wen Huang, †, ‡ Jun Wang, § Peng-Chi Zhang, † Hai-Quan Mao, | Ren-Xi Zhuo, *, ‡ and Kam W. Leong*, §
Biomacromolecules 2004, 5, 306-311,-0001,():
-1年11月30日
A nonionic and water-soluble polyphosphoester, poly(2-hydroxyethyl propylene phosphate) (PPE3), was synthesized by chlorination of poly(4-methyl-2-oxo-2-hydro-1,3,2-dioxaphospholane), followed by esterification with 2-benzyloxyethanol and deprotection of the hydroxyl group by catalytic hydrogenation in the presence of Pd-C. PPE3 degraded rapidly in PBS 7.4 at 37℃. The cytotoxicity and tissue compatibility assays suggested good biocompatibility of PPE3 in vitro and in vivo. The expression of pVR1255 Luc plasmid in mouse muscle after intramuscular (i.m.) injection of DNA formulated with PPE3 solution in saline was enhanced up to 4-fold compared with that of naked DNA. These results suggest the potential of this polyphosphoester for naked DNA-based gene therapy. The advantages of this polymer design include the biodegradability of the polyphosphoester and its structural versatility, which allows the fine-tuning of the physicochemical properties to optimize the enhancement of gene expression in muscle.
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