缪朝玉
从事药理学研究,重点研究心血管疾病、糖尿病等重大疾病的病理新机制和防治新策略
个性化签名
- 姓名:缪朝玉
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学术头衔:
博士生导师, 国家杰出青年科学基金获得者
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学科领域:
药物化学
- 研究兴趣:从事药理学研究,重点研究心血管疾病、糖尿病等重大疾病的病理新机制和防治新策略
缪朝玉,女,1965年4月出生,浙江奉化籍。1981年考入第二军医大学,先后获得该校医学学士(1986)、药理学硕士(1989)和药理学博士(2000)学位。曾在法国做博士后和访问研究(2002,2003),师从国际药理学联合会主席Paul M. Vanhoutte教授(2002)和国际著名高血压专家Jean Sassard教授(2003)。现为第二军医大学药理学教授、博士生导师、教研室副主任。兼任上海市药理学会副理事长、中国药理学会理事、中国药理学会心血管药理专业委员会副主任委员、国内外多种专业期刊编委。自1986年以来从事药理学研究,重点研究心血管疾病、糖尿病等重大疾病的病理新机制和防治新策略。主持国家杰出青年科学基金等课题9项,参加7项。主编书籍6本,参编18本。发表论文118篇,其中SCI论文45篇,得到编辑部评论(Editorial comment)6篇。个人荣获国家杰出青年科学基金(2005)、全国百篇优秀博士学位论文(2003)、上海十佳青年科技英才(2004)、总后勤部科技新星(2004)、上海市曙光学者(2004)、明治乳业生命科学奖优秀奖(2005)、军队院校育才奖(2006)、Servier优秀青年药理学工作者(1999)等。以第二完成人获上海市科技进步一等奖(2003)、上海市自然科学二等奖(2006)、国家新药临床批文(2002)、国家发明专利(2004)各1项。参与编写的《心血管药理学》(第二版,人民卫生出版社)获国家卫生部科技进步二等奖(1999)。
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285
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成果数
5
缪朝玉, Chao-Yu Miao, Ding-Feng Su
Journal of Hypertension 2002, Vol. 20 No. 9,-0001,():
-1年11月30日
Objective The main objective was to examine the role of hemodynamics in rat aortic and left ventricular hypertrophy produced by sinoaortic denervation (SAD). Design and methods Rats were examined at different times after SAD or sham operation (Sham). Hemodynamics were recorded continuously in conscious unrestrained rats. The time course of hemodynamic changes and cardiovascular hypertrophy was observed and linear regression analysis was performed to study the role of hemodynamics in SAD-induced aortic and left ventricular hypertrophy. Long-term mortality, water and food intake, and body weight were also determined after operation. Results High mortality (40%), dramatic reduction of water and food intake, and weight loss occurred within 1 week after SAD. Chronic SAD rats exhibited a marked increase in blood pressure variability (BPV), with no change in the average level of blood pressure (BP), as compared with the Sham control rats. Increased BPV was higher at 2 weeks (about threefold) than 16 weeks (about twofold) after SAD. Aortic hypertrophy existed in all three kinds of examined rats: 2-, 10- and 16-week SAD rats. Left ventricular hypertrophy was found only in 10- and 16-week SAD rats. Both aortic hypertrophy and left ventricular hypertrophy were significantly and positively correlated with BPV, but not with BP level. Conclusion Persistent high BPV following SAD can lead to aortic and left ventricular hypertrophy. The aorta is more sensitive to increased BPV than the heart.
blood pressure variability, arterial baroreflex, denervation, hypertrophy, aorta, heart
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【期刊论文】Comparative Study of Sinoaortic Denervated Rats and Spontaneously Hypertensive Rats
缪朝玉, Chao-Yu Miao, Wen-Jun Yuan, Ding-Feng Su
AJH 2003; 16: 585-591,-0001,():
-1年11月30日
Background: Both hypertension and high blood pressure variability (BPV) are involved in cardiovascular damage. This comparative study was designed to explore the possible effects of both of these phenomena on the cardiovascular system. Methods: The high BPV model of 16-week sinoaortic denervated (SAD) rats and the hypertension model of spontaneously hypertensive rats (SHR) were used for comparison at the same age of 26 weeks. The comparison was focus on hemodynamics, cardiovascular hypertrophy, and hemodynamic responses to ketanserin. Linear regression analysis was performed to study the role of hemodynamics in cardiovascular hypertrophy. Results: In SHR, hypertension was accompanied by a moderately high BPV, whereas in SAD rats, substantially high BPV existed alone, without hypertension. Left ventricular hypertrophy was severe in SHR but was mild in SAD rats. Aortic hypertrophy was present in SAD rats but was absent in SHR. In SAD rats, the hypertrophy was correlated with BPV but not with blood pressure (BP) level. However, in SHR, hypertrophy was correlated with both BP and BPV level. The BP-lowering effect of ketanserin was comparable in both models, whereas its BPV-lowering effect was greater in SAD rats than in SHR. This hypersensitivity was associated with basal BPV level in SAD rats. Conclusions: These results indicate that hypertension may be more important than high BPV in causing left ventricular hypertrophy, and that the aorta may be more sensitive to substantially high BPV.
Blood pressure, blood pressure variability, hypertension, hypertrophy, sinoaortic denervation
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【期刊论文】Acute pressure–natriuresis function shows early impairment in Lyon hypertensive rats
缪朝玉, Chao-Yu Miao, Kiao-Ling Liu, Daniel Benzoni, Jean Sassard
Journal of Hypertension 2005, Vol. 23 No. 6,-0001,():
-1年11月30日
Objective This study aimed to determine whether the alteration of the pressure natriuresis seen in Lyon genetically hypertensive (LH) rats occurs early, and the possible involvement in this alteration of the most important extra-renal factors that influence natriuresis. Methods In LH rats and their normotensive (LL) controls, acute pressure natriuresis was studied in denervated kidneys with or without controlling extra-renal influence; that is, adrenalectomy and an intravenous infusion of vasopressin, norepinephrine, hydrocortisone and aldosterone. Results With controlling the cited extra-renal influence, LH rats already exhibited, at 5 weeks of age, a slightly higher blood pressure (+9%) and a markedly reduced renal blood flow (-33%) compared with LL rats; their pressure–diuresis and pressure–natriuresis curves were significantly blunted. Between 16 and 50 weeks of age, although BP levels did not change, renal blood flow and glomerular filtration rate declined in LH rats while their pressure–diuresis and pressure–natriuresis curves continued to shift to higher pressures. When studied without controlling extrarenal influence, the values of pressure diuresis and natriuresis were significantly higher than in controlled conditions both in LH and LL rats. However, in 16-week-old rats, the LH/LL ratios for sodium and water excretion remained close under the two experimental conditions. Conclusions The pressure–natriuresis function in LH rat shows early impairment and aggravates with age. This alteration is observed with, as well as without, controlling the influence of the main extra-renal factors that affect natriuresis.
pressure natriuresis, renal function, age, genetic hypertension
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缪朝玉, Chao-Yu Miao, Nicole Villeneuve, Christine Brunel-Jacquemin, Christine Petit, Jean-Philippe Guillaumin, Denis Gransagne, Cyril Briant, Jean-Paul Vilaine, Paul M. Vanhoutte
J Vasc Res 2005; 42: 148-156,-0001,():
-1年11月30日
Mild hyperhomocysteinemia is prevalent in the general population and has been linked to endothelial dysfunction and high arterial pressure (AP) in clinical studies. The present study was designed to determine whether a rise in AP was induced by mild hyperhomocysteinemia and whether the potential rise in AP is secondary or prior to endothelial dysfunction. Experiments were performed in a rat model of mild hyperhomocysteinemia induced by oral administration of homocysteine for 1–4 months. Aortic endothelial dysfunction was observed 2 months after homocysteine treatment while endothelium-independent vasodilation was normal. In parallel, homocysteine treatment increased phenylephrine-induced contraction in aortas with endothelium, but did not modify the contraction in aortas without endothelium, suggesting a decrease of basal NO production. In conscious unrestrained rats, AP was not significantly different 1, 2, 3 and 4 months after homocysteine treatment. In correlation, endothelial function of a resistance vessel (mesenteric artery), mainly non-NO nonprostanoid factor mediated, was preserved, indicating that homocysteine treatment only affected the NO pathway. In conclusion, mild hyperhomocysteinemia alone is not sufficient to elevate arterial blood pressure, at least in the rat model. Aortic endothelial dysfunction produced by mild hyperhomocysteinemia is independent of hemodynamic factors.
Arterial pressure, Endothelial dysfunction, Homocysteine, Hyperhomocysteinemia
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缪朝玉, Chao-Yu Miao, He-Hui Xie, Lin-Shu Zhan, Ding-Feng Su
Journal of Hypertension 2006, Vol. 24 No. 6,-0001,():
-1年11月30日
Objective This study was designed to determine how important a novel risk factor of elevated blood pressure variability (BPV) is in the determination of end-organ damage by comparison with the classic risk factor of a high blood pressure (BP) level. Methods and results The effects of haemodynamics on cardiovascular morphology were evaluated by univariate and multivariate regression analysis in two different rat models with an enlarged distribution of haemodynamics. In male sham-operated and sinoaortic-denervated Wistar–Kyoto rats and spontaneously hypertensive rats (n = 34), BPV was more important than BP in cardiac and renal damage and aortic hypertrophy. BPV and BP had independent effects, explaining 59.4% of the variation in damage to these organs. In male (n = 44) and female (n = 46) F1 hybrids of Sprague–Dawley rats and spontaneously hypertensive rats, the greater importance of BPV than BP was further demonstrated in left ventricular hypertrophy, glomerular damage and aortic hypertrophy. The phenomenon was more evident in females than males for cardiovascular hypertrophy. BPV and BP or BPV alone had independent effects, explaining 46.9% (male) or 37.5% (female) of the variation in damage to these organs. Conclusion BPV is a more critical determinant than BP level for cardiac damage, renal lesions and aortic hypertrophy in rats, strongly suggesting the significance of BPV control for the protection of these organs.
Artery, blood pressure variability, heart, kidney, risk factors
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