吴隆民
物理有机化学,自由基化学,磁共振波谱学等,主要集中在有机化学反应机理、自由基反应动力学、正离子自由、生物活性分子的单电子转移反应等
个性化签名
- 姓名:吴隆民
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学术头衔:
博士生导师
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学科领域:
有机化学
- 研究兴趣:物理有机化学,自由基化学,磁共振波谱学等,主要集中在有机化学反应机理、自由基反应动力学、正离子自由、生物活性分子的单电子转移反应等
1967 年毕业于兰州大学化学系。1978 年入兰州大学化学系攻读研究生,导师刘有成院士。1980-1983 年在瑞士苏黎世大学物理化学研究所留学,导师 H. Fischer 教授。1983 年回国,在兰州大学化学化工学院任教。1988-1991 年在瑞士苏黎世大学做访问学者。91 年回国后继续在兰州大学化学化工学院任教。现任功能有机分子化学国家重点实验室(兰州大学)副主任,兰州大学化学化工学院副院长,第二有机化学研究所所长。主开硕士研究生课程:物理有机化学,有机化学近代方法等专业课程。科研方向为物理有机化学,自由基化学,磁共振波谱学等,主要集中在有机化学反应机理、自由基反应动力学、正离子自由、生物活性分子的单电子转移反应等。已获得国家自然科学基金委员会的 3 个面上项目的支持,已在国内外重要学术刊物上发表论文 60 余篇。作为主要成员获 1995年国家科技进步一等奖。
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主页访问
1989
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关注数
0
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成果阅读
315
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成果数
10
吴隆民, WU Longmin, **, GUO Xia, WANG Jun, GUO Qingxiang, , LIU Zhongli and LIU Youcheng
Vol.42 No.2 SCIENCE IN CHINA (Series B),-0001,():
-1年11月30日
Electron transfer reactions take place readily between 2,2,6,6-tetramethylpiperidine oxoammonium ions (1a, 1b) and phenothiazines (2a--2g), giving corresponding nitroxides (3a, 3b) and phenothiazme radical eations (4a--4g). The rate constants for the electron self-exchange reactions between 1 and 3, as well as between 2 and 4, are determined by EPR and IH NMR line-broadening effect in acetonitrile. Fay application of the Marcus theory, the kinetics of the cross-exchange reactions between 1 and 2 is studied.
electron transfer reaction,, phenothiazine,, oxoammonium ion,, Marcus theory.,
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【期刊论文】Oxidative Reactivity of S-Nitrosoglutathione with Hantzsch 1,4-Dihydropyridine
吴隆民, Yu-Zhu Mao, Mei-Zhong Jin, Zhong-Li Liu, and Long-Min Wu*
,-0001,():
-1年11月30日
Nitric oxide (NO) is an endogenous compound of the body involved in a variety of biological processes,1 including immunity-regulating functions, physiological control of blood pressure, and neurotransmission. Authentic NO in vivo has only a 0.1 s half-life.2 Nitrosothiols (RSNO), which are formed in vivo from the reaction of NO with protein or nonprotein thiols, can increase the effective tissue half-life of NO.3 RSNO is commonly referred to as a NO-donor and is found in various biological systems, such as in human plasma, airways, white blood cells, and rat cerebellum.4 Nitrosoglutathione (GSNO) has been shown to be one of the most aboundant RSNOs,4c,5,6 e.g., 0.3μM in bronchial lavage fluid and 0.7μM in brain, and to exhibit depressor action.7
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吴隆民, Jian-Ming Lü†. L. M. Wu†, J. Geimer‡ and D. Beckert
Phys. Chem. Chem. Phys., 2001, 3, 2053-2058,-0001,():
-1年11月30日
Using laser photolysis of basic anaerobic aqueous solutions of a-glycine, L-a-alanine and a-aminoisobutyric acid containing anthraquinone-2,6-disulfonic acid the two spin-polarized (CIDEP) C
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【期刊论文】EPR study of radicals generated from bioactive S-nitrosothiols and related thiols
吴隆民, Jing Jin, Longmin Wu* and Ziyi Zhang
MAGNETIC RESONANCE IN CHEMISTRY Magn. Reson. Chem. 2002; 40:346-352,-0001,():
-1年11月30日
Thermal or photolytic reactions of bioactive S-nitrosothiols and related thiols in the presence of radical generators in deaerated DMSO or aqueous solutions under argon or saturated with nitric oxide (NO) produced nitroxides and an oxyaminyl radical, which were well characterized by EPR spectra. Nitroxides containing a thiyl substituent were obtained. Possible mechanisms are proposed. Bioactive S-nitrosothiols such as S-nitrosoglutathione, S-nitroso-N-acetylpenicillamine and related thiols such as glutathione and N-acetylpenicillamine were used for the investigation. Radical generators utilized as transient radical sources were 2,2'-azobisisobutyronitrile, 2,2'-azobis (2-methylpropionamidine) dihydrochloride, tert-butyl peroxide and benzoyl peroxide.
electron paramagnetic resonance, S-nitrosothiols, thiols, nitroxides, nitric oxide
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吴隆民, Jing Jin, Longmin Wu* and Ziyi Zhang
MAGNETIC RESONANCE IN CHEMISTRY Magn. Reson. Chem. 2002; 40:284-288,-0001,():
-1年11月30日
Photochemical or thermal decomposition of azo-compounds (such as 2,2'-azobisisobutyronitrile, 2,2'-azobis(2-methylpropionamidine) dihydrochloride, dialkyl peroxides (such as tert-butyl peroxide and diacyl peroxides (such as benzoyl peroxide) in anaerobic nitric oxide (NO)-saturated dimethylsulfoxide (DMSO) or aqueous solutions yielded nitroxides. Well-characterized electron paramagnetic resonance spectra of nitroxides revealed that NO was favorable for reacting with carbon-centered and less stereoinhibited transient alkyl radicals, giving kinds of nitrosoalkane, typically nitrosomethane, which act sequentially as C-nitroso compounds to trap transient radicals present in solution, yielding spin-trapping adducts, i.e. nitroxides. Radicals, including sulfinyl radicals from UV-irradiated DMSO, were trapped by the in situ formed CH3NO. O-centered radicals could not add to the freshly formed C-nitroso compounds. Possible mechanisms are suggested.
EPR, nitroxides, nitric oxide, spin trapping
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【期刊论文】A novel reaction of ketone arylhydrazones with nitric oxide
吴隆民, Desuo Yang, a, b Liandi Lei, a Zhongquan Liu a and Longmin Wu a, *
Tetrahedron Letters 44(2003)7245-7247,-0001,():
-1年11月30日
The reaction of ketone arylhydrazone (1) with nitric oxide affords C1'-nitro azo-compounds (2) in good yields. Products were identified by NMR, IR, MS, and X-ray crystallography. The reaction is assumed to be most likely initiated by an electrophilic addition of NO2 to the carbon atom of the carbon-nitrogen double bond.
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【期刊论文】EPR study of nitroxides formed from the reaction of nitric oxide with photolyzed amides
吴隆民, Fan Wang, Jing Jin and Longmin Wu*
MAGNETIC RESONANCE IN CHEMISTRY Magn. Reson. Chem. 2003; 41:647-659,-0001,():
-1年11月30日
Free radicals generated from UV irradiation of simple aliphatic amides in anaerobic and nitric oxide (NO)-saturated liquid mixtures or solutions gave EPR spectra of nitroxides. The application of isotopic effects to EPR spectra and the generation of radicals by transient radical attack on substrate molecules or by photolysing amine or acetoin were used to help identify photochemically produced radicals from the amides. The aliphatic amides used were formamide, acetamide and their N-methyl-or deuteriumsubstituted derivatives. Transient radicals used to attack the amides via hydrogen-atom abstraction were generated from the initiator AIBN or AAPH. The observation of various nitroxides indicates the reactivity of NO for trapping acyl, carbamoyl and other carbon-centered radicals. Possibly mechanistic pathways diagnosed with this trap are proposed.
EPR, nitric oxide, nitroxide, amides, acyl, carbamoyl
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吴隆民, L.-D. LEI, F. WANG, D.-S. YANG and L.-M.WU*
Res. Chem. Intermed., Vol. 30, No. 3, pp. 269-278(2004),-0001,():
-1年11月30日
Stable aminoxyls and an iminoxyl were observed by spin trapping and EPR techniques during the nitrationof coumarins containing a hydroxy group by nitric oxide. The trapped free radicals are deduced to be the resonance stabilized phenoxy-like radicals. The mechanisms for the nitrations are suggested.
Nitration, nitric oxide, coumarins, aminoxyls, EPR, spin trapping.,
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【期刊论文】Novel Reaction of Nitroxide with Hantzsch Dihydropyridines
吴隆民, Man LU, Jian Guo FANG, Zhong Li LIU, Long Min WU*
Chinese Chemical Letters Vol. 13, No. 10, pp 923-925, 2002,-0001,():
-1年11月30日
4-oxo-2, 2, 6, 6-tetramethylpiperidinyl-1-oxy radical (TEMPO), a nitroxide, oxidized 4-substituted Hantzsch 1,4-dihydropyridines (DHP) under UV irradiation in CH3CN to give aromatic products in good yields. A possible mechanism for the oxidation was suggested.
Nitroxide,, Hantzsch dihydropyridines,, photoinduced electron transfer.,
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【期刊论文】Ring opening of 2,3-epoxy phenyl ketones upon reaction with nitric oxide
吴隆民, Zhongquan Liu, a Rui Li, a Desuo Yang a, b and Longmin Wu a, *
Tetrahedron Letters 45(2004)1565-1566,-0001,():
-1年11月30日
Epoxide rings of 2,3-epoxy phenyl ketones were cleaved by nitric oxide, affording regioselectively the C-3 ring-opened products, erythro-a-hydroxyl nitrates (2), in a highly syn-selective manner (isolated yield of the erythro products up to 91%). Products were identified by NMR, MS, and X-ray crystallography. The reaction is assumed to be initiated by NO2, unlike a nucleophilic attack.
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