廖玉华
心血管病免疫学
个性化签名
- 姓名:廖玉华
- 目前身份:
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学术头衔:
博士生导师
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学科领域:
内科学
- 研究兴趣:心血管病免疫学
廖玉华,男,1956年4月生,中共党员。1978-1983年在武汉医学院医学系学习获医学学士学位,1990-1993年在同济医科大学心血管病研究所学习获硕士学位。1983年8月至今在华中科技大学同济医学院附属协和医院、心血管病研究所工作。1996年享受国务院政府津贴。2004年被评为中华人民共和国卫生部有突出贡献中青年专家。现任华中科技大学同济医学院心血管病研究所副所长,协和医院心血管内科主任,博士研究生导师,国家重点学科华中科技大学心血管内科的学科带头人,《欧洲心力衰竭杂志》编委,《临床心血管病杂志》主编,《中华心血管病杂志》编委,中华心血管病学会湖北分会和武汉分会副主任委员,曾担任国家自然科学基金二审专家。作为奠基人之一开创了我国心血管病免疫学研究领域。最早阐明扩张型心肌病免疫介导心肌损伤机制,提出应用钙拮抗剂对扩张型心肌病进行早期干预和保护心肌的新观点。在国际上率先发现肝炎病毒性心肌炎患者抗β1受体抗体机与心肌炎密切相关;率先发现心肌梗死患者血清可检出抗肌球蛋白抗体,证实心肌梗死后病人抗肌球蛋白抗体产生与心室重塑发生的高度相关性。发现原发性高血压患者血清中抗AT1受体抗体和抗α1受体抗体,这些抗体是难治性高血压发生发展的重要因素。晚近,研究出治疗高血压的降压疫苗,为高血压治疗开创新途径。他承担国家自然科学基金项目、卫生部临床学科重点项目、以及参加国家973研究项目、863项目和国家95攻关项目共计17项,获科研资金380万元,在国内外杂志发表论文120篇,SCI收录12篇。培养硕士生28人、博士生22人。在长期的临床实践中积累了丰富的临床经验,擅长诊治疑难心血管疾病,在难治性高血压、难治性心力衰竭、心肌炎心肌病的诊治方面具有独到之处。
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【期刊论文】Prevention of myosin-induced autoimmune myocarditis in mice by anti-L_3T_4 monoclonal antibody
廖玉华
,-0001,():
-1年11月30日
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廖玉华
,-0001,():
-1年11月30日
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廖玉华, WANG Zhaohui, LIAO Yuhua, DONGJihua, LI Shuli, WANGJinping and Michael LX Fu
Chinese Medical Journal 2003; 116 (4): 499-502,-0001,():
-1年11月30日
In order to explore the possible roles played by the autoimmune mechanism in the progre ssion of myocarditis into dilated cardiomyopathy (DCM) using an animal model, we inve stigated whether autoimmune myocarditis might develop into DCM1 Methods Experimental Balb/C mice (n=20) were immunized with cardiac myosin with Freund's complete adjuvant at days 0, 7 and 30. The control Balb/C mice (n=10) were immunized with Freund's complete adjuvant in the same mannere1 Serum and myocardium samples were collected after the first immunization at days 15, 21 and 120. The anti-myo sin antibody wa s examined by enzyme-linked immuno sorbent a ssay and immunoblotting. Results Pathological findings demonstrated that there was myocardial necro sis or inflammatory infiltration during acute stage s and fibro sis mainly in the late phase of experimental group, but the myocardial lesions were not found in the control group. Autoimmunity could induce myocarditis and DCMin the absence of viral infection1 High titer anti-myosin IgG antibodies were found in the experimental group, but not in the control group. Furthermore, the anti-myo sin heavy chain (200 KD) antibody was positive in 21 of 48 patients with DCM and viral myocarditis, but only 4 of 20 patients with coronary heart disease, including. case and 3 cases that reacted with heavy and light chains (27.5KD), respectively. The antibodies were not detected in healthy donors. Conclusion Cardiac myosin might be an autoantigen that provokes autoimmunity and leads to the transformation of myocarditis into DCM. Detection of anti-myosin heavy chain antibody might contribute to diagno sis for DCM and viral myocarditis.
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廖玉华, +, 陶荣, △, 程翔, 童丹, 胡燕, 王敏, 王朝晖
中国分子心脏病学杂志,2002,2(3):7~10,-0001,():
-1年11月30日
目的:探讨急性心肌梗死后心肌是否发生炎症性损伤。方法 在体结扎Wistar大鼠冠状动脉左前降支(LAD)复制急性心肌梗死大鼠模型和假性手术大鼠对照。6周后,酶联免疫吸附试验(ELISA)检测大鼠血清抗肌球蛋白重链抗体。组织学检查心肌病理改变,免疫组织化学染色分析浸润心肌组织T淋巴细胞的表型。结果:急性心肌梗死大鼠(5/12例)血清中检测到抗肌球蛋白重链抗体,阳性率为41.7%,对照组(0/10例)均为阴性(p<0.05)。大大鼠非梗死区心肌组织中出现散在分布的血管周围炎和间质淋巴细胞浸润,免疫组织化学染色显示心股组织CD4+T细胞浸润占有显著优势。结论:急性心肌梗死后心肌组发生了异常的炎症反应。
急性心肌梗死, 自身免疫, 抗体
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【期刊论文】Autoantibodies against AT1-Receptor and α1-Adrenergic Receptor in Patients with Hypertension
廖玉华, Yu-Hua LIAO, Yu-Miao WEI, Min WANG, Zhao-Hui WANG, Hai-Tao YUAN, Long-Xian CHENG
,-0001,():
-1年11月30日
This study will explore the autoantibodies against AT1-receptor and α1-adrenergic receptor in patients with hypertension. Forty normotensives and 194 patients with hypertension were recruited for participation in this study. All patients accepted systemic combination drug treatment for antihypertension. According to the treatment results and the definition of refractory hypertension, the patients were divided into two groups: a refractory hypertension group and a non-refractory hypertension group. The epitope of the 2nd extracellular loop of type 1 angiotensin (AT1) receptor and α1-adrenergic receptor were synthesized and used as antigens to screen the autoantibodies against AT1-receptor and α1-adrenergic receptor by ELISA. The plasma renin activity and concentration of angiotensin II and catecholamine were also examined. The positive rates of the autoantibodies against AT1-receptor and α1-adrenergic receptor in patients with hypertension, 26.8% (52/194) and 25.3% (49/194), respectively, were higher than those in normotensives (7.5% and 5%)(p<0.01). Further investigation showed that the frequencies of the autoantibodies against AT1-receptor and α1-adrenergic receptor in patients with refractory hypertension, 42.9% (42/98) and 36.7% (36/98), respectively, were higher than those in patients with non-refractory hypertension under systematic treatment (10.4% and 13.5%)(p<0.01). The levels of circulating angiotensin II, catecholamine, proteinuria and serum creatine were also higher in the refractory hypertension group than in the non-refractory hypertension group. The findings showed that the frequencies of autoantibodies against AT1-receptor and α1-adrenergic receptor were higher in patients with hypertension, particularly in those with refractory hypertension, and that these autoantibodies might play a role in the pathogenesis of hypertension.
hypertension,, refractory,, autoantibodies,, AT1-receptor,, α1-adrenergic receptor
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廖玉华, ZHAO-HUI WNAG a, YU-HUA LIAO a and MICHAEL Fu b, *
Autoimmunity, Vol. 34, pp. 241-245,-0001,():
-1年11月30日
The aim of this study was to examine the frequency of occurrence of autoantibodies against β1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correla tion with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=29) and a negative group (Non-HVM group, n=74) according to the laboratory findings regarding their type of hepatilus virus. The study param eters included UCG, ECG, biochemical lindings and screening of autoantibodies against βl-adrenoceptor. It was shown that the positive rate of the hepatitis vies was 28.16% (29/103) in patients with viral myocarditis. The severity of myocardial or liver injunes and the frequency of occurrence of autoantibodies againsl β1-adrenoceptors in patients with viral myocaditis were more pronounced, before treatment, in the HVM group than in the Non HVM group The positive rates of the antibodies against the hepatitis virus and the autoantibodies agzainst β1-adrenoceptors were highly consistent in patients with HVM (p<0.05). In conclusion, the frequency of occurrence of the autoantihodies against β1 -adreno ceptors may be one important marker of HVM and. Thus. possibly involved in the pathogene sis of the HVM.
hepatitis, hepatitis vin/, s myocarditis, autoantibodies against, β1-adrenoceptors
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