许鹏飞
(1)几种海洋天然产物的全合成研究;(2)-氨基酸的不对称合成、不对称催化及方法学研究;(3)特定杂环化合物的合成及生物活性研究
个性化签名
- 姓名:许鹏飞
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
有机化学
- 研究兴趣:(1)几种海洋天然产物的全合成研究;(2)-氨基酸的不对称合成、不对称催化及方法学研究;(3)特定杂环化合物的合成及生物活性研究
许鹏飞博士现为兰州大学教授,博士生导师。1999.11至2001.6年赴台湾中兴大学进行访问研究;2003.1至2003.6以客座研究员身份赴日本名古屋大学进行合作研究;2003.7-2004.6以访问教授身份在日本名古屋大学物质材料科学国际研究中心进行合作研究。现任兰州大学化学化工学院杂环与杂原子化学研究室主任,有机化学研究所副所长,兰州大学应用有机化学国家重点实验室副主任。
现承担教育部重点项目,国家自然科学基金等多项课题,为兰州大学有机化学创新群体骨干成员,2002年获得第九届甘肃省青年教师成才奖、先后获得甘肃省科技进步三等奖两项与甘肃省高校科技进步二等奖两项。
目前主要从事(1)几种海洋天然产物的全合成研究;(2)-氨基酸的不对称合成、不对称催化及方法学研究;(3)特定杂环化合物的合成及生物活性研究。许鹏飞教授同时注重国际交流与合作,利用与搭建国际协作平台,广泛且卓有成效的开展工作。
目前,共合成具有较强生物活性的新杂环化合物200多种。首次建立了以樟脑酮为原料,高光学选择性的制备天然与非天然氨基酸的方法,为氨基酸的合成开辟了一条新路,这些工作受到了国际同行的较高评价。 目前发表论文53篇,其中《SCI》收录论文35篇,发明专利2项。
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成果阅读
253
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成果数
7
许鹏飞, Yan Zhanga, Ren-Zhong Qiaoa, Peng-Fei Xua*, Zi-Yi Zhanga*, Qin Wang b, Li-Min Maob and Kai-Bei Yuc
Jour nal of the Chi nese Chem i cal So ci ety, 2002, 49, 369-373,-0001,():
-1年11月30日
Eigh teen novel 2-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-1,3,4-oxadiazole de riv a tives and two acyl hy-drazone in ter me di ate com pounds were syn the sized by var i ous path ways start ing from 1-aryl-5-methyl-1,2,3-triazol-4-formhydrazide (1). All prod ucts were iden ti fied by spec tro scopic anal y sis, and 2-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-benzalthio-1,3,4-oxadiazole was fur ther val i dated by X-ray crys tal log ra phy. Re-sults from pri mary an ti bac te rial ac tiv ity tests in di cated that most of the com pounds were ef fec tive against E. coli, P. aeruginosa, B. subtilis and S. aureus.
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许鹏飞, Dong Liu, Su-Yan Liu, Xin-Ping Yang, Peng-Fei Xu* and Zi-Yi Zhang
Jour nal of the Chi nese Chem i cal So ci ety, 2002, 49, 251-254,-0001,():
-1年11月30日
The prep a ra tion and char ac ter iza tion of some dipositive metal ion com plexes de rived from po tas sium 3-(pyridine-4-carbonylmethyl)-dithiocarbazate (PCDHK) are re ported. The solid com plexes of the com po si-tion ML
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许鹏飞, Peng-Fei Xua, Tahsin J. Chowb, Richard Limb and Ta-Jung Luc
Jour nal of the Chi nese Chem i cal So ci ety, 2003, 50, 135-142,-0001,():
-1年11月30日
The E and Z-iso mers of the ti tled com pound were syn the sized by con den sa tion of 2-carboxaldehyde- 8-alkyloxyquinoline and N-cyanomethylcarbazole, fol lowed by hy dro ly sis. The alkoxy pro tec tion groups in 3b-c can be cleaved ei ther in acid or in base to yield 3a. All com pounds ex hibit blue/green lu mi nes cence, which may be used as emit ting ma te rials in the fab ri ca tion of light-emitting di odes. Crys tal dif frac tion anal y-ses were per formed for 3a-E, 3d-Z, and 4-Z, while the re sults in di cated the pres ence of a com mon struc tural fea ture among these mol e cules. The rings of quinoline are co-planar with the dou ble bond of crylonitrile, form ing a ma jor con ju gated chromo phore. The carbazole group is twisted along the N(9)-C(2) bond away from the ma jor plane with a large di hed ral an gle. The ma jor con ju gated chromphore was found to be re spon si-ble for the spec tral prop er ties of these com pounds. Protonation of the quinoline in these com pounds redshiftedtheir ab sorp tion bands sub stan tially.
Carbazole, Hydroxyquinoline, OLED.,
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许鹏飞, Peng-Fei Xua*, Zhi-Hui Zhanga, Xin-Ping Huia, Zi-Yi Zhanga and Rong-Liang Zhengb
Jour nal of the Chi nese Chem i cal So ci ety, 2004, 51, 315-319,-0001,():
-1年11月30日
Com pounds 2-arylamino-5-cinchophenyl-1,3,4-oxadiazoline (7) and 3-thio-4-amino-5-cinchophenyl- 1,2,4-triazole (3) have been syn the sized uti liz ing cinchophen as the start ing ma te rial. The com pound 3-cinchopheny-s-triazolo[3,4-b]-1,2,3,4-thiatriazole (4) was pre pared from com pound 3. Con den sa tion of 3 with ar o matic acid in the pres ence of POCl3 gave 10 new 6-aryl-3-cinchopheny-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (5). Some of the rep re sen ta tive com pounds were screened for an ti bac te rial ac tiv ity. The struc-tures of these new com pounds have been con firmed by means of el e men tal anal y sis, IR, 1H NMR and MS.
Cinchophen, Syn the sis, Tri azoles, Oxadiazoles, Con densed heterocyclic com pounds, Biolog icalactivity.,
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【期刊论文】A green route to the synthesis of azo compounds
许鹏飞, Ren-Zhong Qiao, a Yan Zhang, a Xin-Ping Hui, a Peng-Fei Xu, *a Zi-Yi Zhang, *a Xiao-Yang Wangb and Yu-Lu Wangc
Green Chemistry, 2001, 3, 186-188,-0001,():
-1年11月30日
Polyethylene glycol (PEG, average molecular weight 400) was used as an absorbent for NO2, the absorptivity was found to reach up to 97%. PEG
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许鹏飞, Peng-Fei Xu, † Yuan-Shek Chen, ‡ Shu-I Lin, ‡ and Ta-Jung Lu*, ‡
J. Org. Chem. 2002, 67, 2309-2314,-0001,():
-1年11月30日
The development of a highly efficient and stereoselective methodology for the preparation of R-amino acids is described. The chiral template, tricyclic iminolactone 7, was synthesized from (1R)-(+)- camphor in five steps in 50% overall yield. Alkylation of iminolactone 7 afforded the R-monosubstituted products in good yields (74-96%) and excellent diastereoselectivities (>98%). Hydrolysis of the alkylated iminolactones furnished the desired R-amino acids in good yields and enantioselectivities with nearly quantitative recovery of the chiral auxiliary 4.
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许鹏飞, Peng-Fei Xu† and Ta-Jung Lu*, ‡
J. Org. Chem. 2003, 68, 658-661,-0001,():
-1年11月30日
Preparation of L-R-amino acids was easily accomplished simply by exchanging the position of the lactone group of our recently reported chiral template 1 from C2 to C3. The new chiral template 7 was prepared in 54% overall yield over five steps from (1R)-(+)-camphor. Alkylation of iminolactone 7 afforded the R-monosubstituted products in good yields and excellent iastereoselectivities (>98%). Hydrolysis of the alkylated iminolactones furnished the desired L-R-amino acids in good yields and ee with nearly quantitative recovery of chiral auxiliary 4.
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