再帕尔
个性化签名
- 姓名:再帕尔
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
有机化学
- 研究兴趣:
再帕尔•阿不力孜,1979-1983年新疆大学化学系本科毕业,留校任教;1985-1988年作为新疆维吾尔自治区第一批派赴日本留学生,在日本明星大学化学系留学,获硕士学位;1988-1991年,先后任新疆大学化学系助教、讲师、副教授;1991-1993年再次留学日本,在东邦大学理学院获得理学博士学位;1993-1994年作为客座研究员,在东邦大学药学院从事科研工作;1994-1996年在中国医学科学院药物研究所从事博士后研究;1996年作为中国医学科学院/中国协和医科大学引进人才在药物研究所工作至今。1997年晋升为研究员、2000年被评为博士生导师,2002年开始担任所仪器分析中心主任、国家药物及代谢产物分析研究中心副主任,2004年担任院校学术委员会委员、院校长助理;这期间(2001.10-2002.3)作为日本科学技术振兴事业团和千叶大学分析中心客座研究员。
主要学术成就:在有机质谱学的离子化、裂解机理和结构特征的研究中,提出了部分电荷分散于不同杂原子以及解释裂解反应的吸引-排斥作用等新观点。首次证实和提出了弱于氢键称之为‘准氢键’的存在,从理论上扩展了氢键的覆盖面。运用串联质谱技术完成了一系列天然产物和生物分子的分子鉴别及其裂解特征研究,并发现了一系列新的特征裂解反应。建立了用于药用植物中常量及微量成分分析的高效、快速的互补性质谱分析方法,为寻找微量活性成分或代谢产物提供了有效分析途径。最近,开展了有机及生物分子间弱相互作用的新课题。分别在《中国科学》、《科学通报》、《J. Chem. Soc.》、《J. Mass Spectrom.》、《Rapid Commun. Mass Spectrom.》、《J. Am. Soc. Mass Spectrom.》和《J. Chromatogr. B.》等国内外学术刊物上发表50余篇论文,其中在SCI收录论文20余篇,值得指出的是这些论文大部分是近五年发表;另外,参与撰写著作三部、分析化学辞典一部。先后获得北京市爱国立功标兵称号、中国分析测试协会科学技术奖二等奖(2次)等。2004年当选为首批“新世纪百千万人才工程”国家级人选。
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392
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成果数
12
再帕尔, Feng Liang, Li-jun Li, Zeper Abliz*, Yun-chong Yang and Jian-gong Shi
Rapid Commun. Mass Spectrom. 2002; 16: 1168-1173,-0001,():
-1年11月30日
The structural characterization of four steroidal saponin compounds involving two and three sugar groups, nanamely spirostanol saponins and furostanol saponins f were investigated by positive ion fast-atom bombardment (FAB), electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS) techniques. Important structural information was obtained from collision-induced dissociation (CID) and FAB-MS spectra with different liquid matrices. It was found that a式characteristic fragmentation involving the loss of 144 Da arising from the cleavage of the E-ring was observed when there was no sugar chain at the C-26 position. When a glucoside group was sub-stituted at the C-26 position, this C-26 sugar moiety was preferentially eliminated. All of these compounds produced a major product ion with a stable skeleton structure at m/z 255. The results of this paper can assist structural analysis of mixtures of steroidal saponins.
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【期刊论文】液相色谱-质谱联用方法在药用植物成分分析中的作用
再帕尔, 项 , 李立军, 再帕尔·阿不力孜*
Ada Pharmaceutica Slnlca 2002, 37 (5): 389-395,-0001,():
-1年11月30日
药用植物, 快速分析, M-MS, MS/, MS
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【期刊论文】Study on fragmentation behavior of 5/7/6-type taxoids by tandem mass spectrometry
再帕尔, Yan Chang, Zeper Abliz, * Li-Jun Li, Qi-Cheng Fang and Mitsuo Takayama
JOURNAL OF MASS SPECTROMETRY J. Mass Spectrom. 35, 1207-1214 (2000),-0001,():
-1年11月30日
The mass spectrometric behaviors of seven compounds, namely four 4b(20),5-oxetane 5/7/6-type taxoids (i.e. taxayuntin A, taxayuntin B, taxayuntin and taxayuntin C) and three 4 (20)-methylene 5/7/6-type taxoids (i.e. brevifoliol, taxchinin A and 7-acetyl-10-deacetyl-7-debenzoylbrevifoliol) have been investigated by the positive ion FAB-MS/MS technique. The fragmentation has been correlated with the types and positions of substituents of these compounds. It has been found that with the OH group at the C-10 position, taxayuntin A, taxayuntin B and 7-acetyl-10-deacetyl-7-debenzoylbrevifoliol are dominated by the loss of H2O, while with the BzO group at the C-10 position, taxayuntin, taxayuntin C, brevifoliol and taxchinin A preferentially eliminate the BzO group. In addition, C-2 is an active site, and neutral loss from the C-2 position readily occurs. The four 4b (20), 5-oxetane 5/7/6-type taxoids produce the terminal product ion with a stable conjugated system at m/z 311, while the 4 (20)-methylene 5/7/6-type taxoids brevifoliol and 7-acetyl-10-deacetyl-7-debenzoylbrevifoliol produce this ion at m/z 237, and taxchinin A at m/z 253. Interestingly, characteristic fragment ions involving the loss of a 118 u group were observed for taxayuntin, and a possible fragmentation mechanism is given. The major fragmentation pathways and mechanisms of ion formation for the compounds are proposed on the basis of CID spectra and accurate mass measurements. The results of this paper will be helpful for structural analysis of analogs.
5/, 7/, 6-type taxoids, fast atom bombardment, collision-induced dissociation, tandem mass spectrometry, fragmentation behavior
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再帕尔, Jin-ping Qiao, Zeper Abliz*, Feng-ming Chu, Pei-ling Hou, Feng Liang, Yan Chang and Zong-ru Guo
RAPID COMMUNICATIONS IN MASS SPECTROMETRY Rapid Commun. Mass Spectrom. 2004; 18: 3142-3147,-0001,():
-1年11月30日
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再帕尔, Yun Xiang and Zeper Abliz, Mitsuo Takayama
,-0001,():
-1年11月30日
The dissociation reactions of the adduct ions derived from the four self-complementary deoxydinucleotides, d(ApT), d(TpA), d(CpG), d(GpC), and alkali-metal ions were studied in detail by positive ion electrospray ionization multiple-stage mass spectrometry (ESI-MSn). For the [M+H]+ ions of the four deoxydinucleotides, elimination of 5'-terminus base or loss of both of 5'-terminus base and a deoxyribose were the major dissociation pathway. The ESI-MSn spectra showed that Li+, Na+, and Cs+ bind to deoxydinucleotides mainly by substituting the H+ of phosphate group, and these alkali-metal ions preferred to bind to pyrimidine bases rather than purine bases. For a given deoxydinucleotide, the dissociation pathway of [M + K]+ ions differed clearly from that of [M+ Li]+, [M+ Na]+, and [M+ Cs]+ ions. Some interesting and characteristic cleavage reactions were observed in the product-ion spectra of [M+ K]+ ions, including direct elimination of deoxyribose and HPO3 from molecular ions. The fragmentation behavior of the [M+ K]+ and [M+ W]+ (W+Li, Na, Cs) adduct ions depend upon the sequence of bases, the interaction between alkali-metal ions and nucleobases, and the steric hindrance caused by bases.
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再帕尔, Jin-ping Qiao a, Zeper Abliz a, *, Feng-ming Chua, Pei-ling Houa, Li-yan Zhao a, Min Xia b, Yan Chang a, Zong-ru Guo a
Journal of Chromatography B, 805(2004)93-99,-0001,():
-1年11月30日
6-Aminobutylphthalide (ABP) is a new drug candidate which is currently being developed for the treatment of cerebral ischemia. The pharmacokinetics and metabolism of ABP were studied using in situ microdialysis sampling in the brains of awake freely-moving rats. Two LC-MS/MS methods were used for the quantitative and qualitative analysis of microdialysate. For comparison and confirmation, brain tissue samples were also analyzed by LC-MS/MS and GC/MS. The results described provide more authentic information in pharmacokinetics and metabolism at the site of action by using the coupling of microdialysis to LC-MS/MS technique than the traditional sampling methods.
6-Aminobutylphthalide
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再帕尔, Rui-ping Zhang, Zeper Abliz*, Feng Liang, Li-jie Cui, Yun Xiang, Xin-sheng Lei and Zong-ru Guo
RAPID COMMUNICATIONS IN MASS SPECTROMETRY Rapid Commun. Mass Spectrom. 2004; 18: 584-587,-0001,():
-1年11月30日
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再帕尔, Yongzhen Liu, Feng Liang, Lijie Cui, Min Xia, Liyan Zhao, Yongchun Yang, Jiangong Shi and Zeper Abliz*
RAPID COMMUNICATIONS IN MASS SPECTROMETRY Rapid Commun. Mass Spectrom. 2004; 18: 235-238,-0001,():
-1年11月30日
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再帕尔, Lijie Cui, Zeper Abliz*, Min Xia, Liyan Zhao, Song Gao, Wenyi He, Yun Xiang, Feng Liang and Shishan Yu
RAPID COMMUNICATIONS IN MASS SPECTROMETRY Rapid Commun. Mass Spectrom. 2004; 18: 184-190,-0001,():
-1年11月30日
Electrospray ionization multi-stage tandem mass spectrometry (ESI-MSn) and liquid chromatography coupled with sequential mass spectrometry (LC/MSn) were applied to identify trace-level phenanthroindolizidine alkaloids in crude extracts from Tylophora atrofolliculata. Based on the relationship between the characteristic fragmentation reactions and the structural features of related compounds of known structure from this plant, the bioactive crude extract was analyzed in detail by positive and negative ion ESI-MSn, LC/UV-MS and LC/MSn techniques. A total of nine constituents in the crude extract were identified rapidly, including several isomers; seven of these constituents are new and two are known compounds. The structures of four of these constituents were subsequently confirmed by nuclear magnetic resonance (NMR) and accurate mass measurements using high-resolution fast-atom bombardment mass spectrometry (FAB-HRMS).
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再帕尔, Yun Xiang, Zeper Abliz*, Li-jun Li and Mitsuo Takayama
RAPID COMMUNICATIONS IN MASS SPECTROMETRY Rapid Commun. Mass Spectrom. 2003; 17: 1220-1224,-0001,():
-1年11月30日
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