马根山
心血管病
个性化签名
- 姓名:马根山
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
内科学
- 研究兴趣:心血管病
姓名:马根山
性别:男
出生年月:1963年2月
医学博士、主任医师、教授、博士研究生导师;
东南大学附属中大医院心血管内科主任、东南大学心血管病研究所副所长;
1983年获扬州医学院临床医学专业学士学位;
1989年开始从事心血管病临床诊疗工作;
1991年获南京医科大学内科学专业硕士学位;
1994年获南京医科大学内科学(心血管病)专业博士学位;
2000.12-2001.12 在澳大利亚维多利亚心脏中心作为高访学者、从事介入性心脏病学研修。
长期从事心血管病临床医疗工作,对危重病人的抢救有丰富的经验。擅长心脏电生理检查、心脏起搏器置入和冠心病介入治疗,已独立完成和指导完成冠状动脉球囊成型术和支架术3000余例,组织和主持国际性冠心病血运重建学术会议5次。在国内外核心期刊发表中英文论著40余篇、主编介入心脏病学专著1部,参编专著、教材8部。获得江苏省科技进步奖4项、南京市科技进步奖1项、江苏省卫生厅医学新技术引进奖9项。现主持2005年国家自然科学基金1项、国家科技公关协作课题和省部级课题6项。指导毕业硕士、博士研究生20余名。现为国家自然科学基金同行评议专家组成员、江苏省中西医结合学会心血管病学分会副主任委员、江苏省医学会心血管病学分会委员和中国介入心脏病学杂志编委等。为江苏省“科教兴卫”工程、“333”工程重点培养人才。
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255
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成果数
8
【期刊论文】Tetramethylpyrazine-Eluting Stents Prevented In-Stent Restenosis in a Porcine Model
马根山, Genshan Ma, MD, PhD, Shu Ding, MMed, Yi Feng, Chengxing Shen, Lijuan Chen, and Zhong Chen
J Cardiovasc Pharmacol TM 2007; 50: 201-205,-0001,():
-1年11月30日
Objective: Tetramethylpyrazine, a drug originally isolated from the rhizome of Ligusticum walliichi, is an inhibitor of phosphodiesterase and inhibits platelet aggregation and smooth muscle cell proliferation. The effect of the tetramethylpyrazine-eluting stent (TES) on preventing in-stent restenosis was investigated in comparison with control bare metal stents in a porcine coronary stent restenosis model. Methods: The TES was prepared by spray-coating the 2.5 to 3.0mm×15 to 20mm bare metal stents with Tetramethylpyrazine monomer, methyl methacrylate copolymer, and polyglycolic acid. Stent overdilation injury (stent:artery=1.1 to 1.2:1.0) was made with control bare stents (n=5) and TES (n=5) in porcine coronary arteries. Follow-up quantitative coronary angiography (QCA) and histopathological assessments of stented coronary arteries were performed 4 weeks after stenting. Results: Quantitative coronary angiography showed the late lumen loss (0.28±0.08mm versus 1.70±0.52mm; P=0.004) and percentage diameter stenosis (10.0±2.1% versus 60.2±23.5%; P=0.01) were significantly lower in the TES group than that in the control group. Histopathological assessments of stented coronary arteries showed that the injury score and the in-stent area were similar between the groups (P>0.05), whereas the lumen area was significantly larger (4.34±0.93 mm2 versus 1.29±1.02mm2; P=0.011) in the TES group than that in the control group. The number of proliferating cell nuclear antigen-positive cells was also significantly decreased in the TES group compared with the control group (14.7±2.5% versus 23.6±3.2%; P=0.008). Moreover, apoptosis was enhanced in TES group while regrowth of endothelium was similar between the groups. Conclusions: TES inhibited the neointimal hyperplasia and reduced in-stent restenosis in a porcine coronary artery restenosis model.
tetramethylpyrazine, drug-eluting stent, restenosis, porcine coronary artery model
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马根山, QI Chun-mei, MA Gen-shan, LIU Nai-feng, SHEN Cheng-xing, CHEN Zhong, LIU Xiao-jun, HU Yao-peng, ZHANG Xiao-li, TENG Gao-jun, JU Sheng-hong, MA Ming and TANG Yao-liang
Chin Med J 2008; 121 (6): 544-550,-0001,():
-1年11月30日
Background Mesenchymal stem cells (MSCs) transplantation provides a new approach for myocardial repair. However, many important fundamental questions about MSCs transplantation remain unanswered. There is an urgent need to identify MSCs from the beating heart and analyze the efficacy of this new approach. This study aimed to localize the magnetically labeled MSCs (MR-MSCs) and monitor the restorative effects of MR-MSCs with magnetic resonance (MR) imaging. Methods Acute myocardial infarction (AMI) was created in swine by a balloon occlusion of the left anterior descending coronary artery. Cells were delivered via intracoronary infusion after myocardial infarction. Infarct size change and cardiac function were assessed with 3.0T MR scanner. The results were then confirmed by histological and western blot analysis. All statistical procedures were performed with Systat (SPSS version 12.01). Results A total of 26 swine were divided into four groups (sham-operated group, n=6; AMI group with PBS transplantation, n=6; labeled MSCs group, n=7; unlabeled MSCs group, n=7). MSCs, MR-MSCs (107cells) or PBS were delivered by intracoronary injection after MI and serial cardiac MR imaging studies were performed at 0, 4 and 8 weeks after transplantation. MR imaging demonstrated MI size decreased after MSCs transplantation in labeled and unlabeled groups, however, increases were seen in the AMI group at 8 weeks after MI. The left ventricular ejection fraction (LVEF) was slightly increased in the AMI group ((41.87±2.45)% vs (39.04±2.80)%, P>0.05), but significantly improved in the MR-MSCs group ((56.85±1.29)% vs (40.67±2.00)%, P<0.05) and unlabeled group ((55.38±1.07)% vs (41.78±2.08)%, P<0.05) at 8 weeks after treatment. MR-MSCs were further confirmed by Prussian blue and immunofluorescent staining. Western blot analysis demonstrated that there was an increased expression of cardiomyocyte markers such as myosin heavy chain and troponin T in the MSCs treatment groups and the ratio of matrix metalloproteinase 2 to tissue inhibitor of metalloproteinase 1 decreased in the labeled group and unlabeled group compared with the AMI group and sham-operated group. Conclusion Transplanted MR-MSCs can regenerate new myocardium and prevent remolding in an MI model at 2-month follow-up and represent a preferred method to better understand the mechanisms of stem cell therapy in future clinical studies.
magnetic resonance imaging, contrast media, mesenchymal stem cell, myocardial infarction, ventricular function
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【期刊论文】A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease
马根山, Zhong Chen·Qi Qian·Genshan Ma·Jiahong Wang·Xiaoli Zhang·Yi Feng·Chengxing Shen·Yuyu Yao
Mol Biol Rep (2009) 36: 889-893,-0001,():
-1年11月30日
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis C50% or previous myocardial infarction and 232 controls without documented coronary artery disease. Ligase detection reaction was performed to detect two SNPs. After adjustment of clinical parameters, significant associations were identified for the rs2383207 and rs10757278 SNPs, with A/G and G/G genetypes at rs10757278 and G/G genetype carriers at rs2383207 having a higher risk of early-onset coronary artery disease than carriers of A/A genotype (odds ratio [OR] 2.207, 95% CI: 1.069-4.394, P=0.028; OR 3.051, 95% CI: 1.086-8.567, P=0.004; OR 2.964, 95% CI: 1.063-8.265, P=0.038, respectively). There were no associations between rs10757278 and rs2383207 genotypes and the severity of coronary artery disease (both P[0.05). Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease. These markers may help the identification of patients at increased risk for early-onset coronary artery disease.
Coronary artery disease,, Early-onset,, Single nucleotide polymorphisms,, Genetic,, Gene
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马根山, Qi Qian·Zhong Chen·Genshan Ma·Yibo Jiang·Yi Feng·Chengxing Shen·Yuyu Yao·Jiandong Ding·Qiming Dai·Yongjun Li
Mol Biol Rep (2009) 36: 1257-1261,-0001,():
-1年11月30日
Background Inflammation plays an important role in coronary artery disease (CAD). Complement Factor H (CFH) gene has been analyzed in relation to CAD in several studies with conflicting results. The aim of the present study was to investigate the association between the CFH Y402H polymorphism and CAD in Chinese. Methods and results About 336 patients were enrolled, included 166 patients with CAD and 170 controls. The SNP at CFH Y402H was genotyped by ligase detection reaction and plasma levels of CFH were assayed by enzyme-linked immunosorbent assay. Analysis of genotype frequencies did not reveal any significant difference between CAD patients and controls. There were significant differences in the frequencies of C allele and C allele carriers between early-onset CAD and controls. After adjustment of clinical parameters, significant association was identified for CFH Y402H polymorphism, with C allele carriers having a higher risk of early-onset CAD than carriers of TT genotype (odds ratio [OR] 4.66, 95% CI: 1.23-17.62, P=0.02). There was no difference of plasma CFH levels between CAD group and controls. Conclusions CFH Y402H polymorphism is associated with early-onset CAD in Chinese.
Single nucleotide polymorphism,, Coronary artery disease,, Early-onset,, Gene polymorphism,, Complement factor H
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马根山, Chen Zhong·Zhang Luzhan·Ma Genshan·Wang Jiahong·Zhang Xiaoli·Qian Qi
Mol Biol Rep (2010) 37: 7-12,-0001,():
-1年11月30日
Background We examined the -2518G/A polymorphism of the MCP-1 gene, its plasma levels, and premature stableCADin a Chinese population. Methods The study comprised 132 patients with premature stable CAD (cases) and 153 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and grouping. Plasma MCP-1 level was detected with enzyme-linked immunosorbent assay. Results No differences were found between genotype distribution and allele frequencies of MCP-1 gene -2518 G/A polymorphism (AA:18.1%; AG:51.5%; GG:30.3% in cases; AA:16.3%; AG:52.9%; GG:30.7% in controls; P=0.918). The G allele prevalence was 0.561 in cases and 0.572 in controls (P=0.786). No significant difference was found in plasma MCP-1 level between cases and controls [(47.50±26.65) vs. (41.05±15.71)pg/ml, P=0.272)] or among the 3 genotypes [AA, (43.49±10.50) pg/ml; AG, (46.09±25.08)pg/ml; GG, (40.03±18.13)pg/ml; P=0.381]. Logistic regression analysis confirmed the lack of association between MCP-1-2518 G/A single nucleotide polymorphism and premature stable CAD after adjustment for confounding parameters. Conclusions The MCP-1-2518 G/A single nucleotide polymorphism does not affect plasma levels of MCP-1 or susceptibility to premature stableCADin a Chinese population.
Premature stable coronary artery disease, Monocyte chemoattractant protein, Genetic polymorphism
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【期刊论文】Toll-like receptor 8 polymorphism and coronary artery disease
马根山, Zhong Chen·Genshan Ma·Qi Qian·Yuyu Yao·Yi Feng·Chengchun Tang
Mol Biol Rep (2009) 36: 1897-1901,-0001,():
-1年11月30日
Toll-like receptors (TLRs) play roles in innate and adaptive immune responses. Some TLRs are involved in the pathogenesis of cardiovascular diseases. Coronary artery disease (CAD) has an inflammatory and immunological basis. We investigated whether TLR8 Met1Val and TLR8-129G>C single nucleotide polymorphisms (SNPs rs3764879 and rs3764880) are associated with CAD in the Chinese population. We enrolled 412 consecutive patients (185 with coronary stenosis ≥50% or previous myocardial infarction and 227 controls). Ligase detection reaction was performed to detect SNPs rs3764879 and rs3764880 of TLR8. The SNP at rs3764879 is in complete linkage disequilibrium with rs3764880. No significant difference was found in genotypic or allelic frequencies of these two common SNPs between CAD cases and controls (P>0.05, respectively). No associations existed between these two SNPs and the severity of coronary artery stenosis (All P>0.05). These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.
Coronary artery disease, Single nucleotide polymorphisms, Toll-like receptors
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【期刊论文】Biocompatibility of tetramethylpyrazine-eluting stents in normal porcine coronary arteries
马根山
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-1年11月30日
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【期刊论文】Tetramethylpyrazine-Eluting Stents Prevented In-Stent Restenosis in a Porcine Model
马根山
,-0001,():
-1年11月30日
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