涂永强
致力于探讨天然产物全合成及有机合成方法学。
个性化签名
- 姓名:涂永强
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 中国科学院院士, 国家杰出青年科学基金获得者, 教育部“新世纪优秀人才支持计划”入选者,
- 职称:-
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学科领域:
有机化学
- 研究兴趣:致力于探讨天然产物全合成及有机合成方法学。
涂永强 教授,男,兰州大学特聘教授,博士生导师。1958年10月生;1982年毕业于兰州大学有机化学专业, 1989年获博士学位并留校任教;1993年1月至1995年11月在澳大利亚昆士兰大学作博士后研究员。曾任兰州大学化学系副主任、兰州大学化学化工学院化学系主任。现任兰州大学功能有机分子化学国家重点实验室主任,兰州大学有机化学研究所所长,中国化学会理事,甘肃省化学会副理事长, 国家“有机化学创新群体”学术带头人。此外,还担任《中国药物化学杂志》、《石化技术与应用》、《药物分析》杂志编委,Tetrahedron/Tetrahedron Lett(四面体/四面体快报)杂志特约审稿人。
自1995年底归国后,涂永强教授致力于探讨天然产物全合成及有机合成方法学,并在合成有机化学领域做出了非常优秀的、具有开拓性的工作。
主要工作包括:
具有抗HIV活性复杂天然产物Didemnaketal的合成研究;
二氢沉香呋喃倍半萜的合成方法研究,该方法被2002年Chem. Soc. Rev. 杂志 (IF 9.2) 所评述,同行专家予以高度评价
新的杂环丙烷醇重排/还原串联反应研究及其在复杂天然产物合成中的应用。该系列方法获得2002年度甘肃省科技进步一等奖;
环境友好反应体系中的化学反应研究。关于硅胶固载不对称氢转移反应的工作被Green Chemistry杂志(2004年)作为Highlight文章进行综述评价。
涂永强教授现已主持包括“杰出青年基金”、“创新群体基金”、“国家自然科学‘十五’重大项目基金”、 “跨世纪人才基金”等近二十项基金课题,现已发表学术论文112篇,其中SCI论文100篇,研究工作主要发表在Angew. Chem. Int. Ed., Chem. Eur. J., Chem. Commun., Org. Lett., J. Org. Chem.等国际重要刊物上,并得到国内外同行的应用及高度评价。此外还获得发明专利2项。获得的主要奖项有:1992年“中国化学会优秀青年化学奖” 、1993年度“国家教委科技进步二等奖”、2000年获得香港“求是科技基金会”颁发的“杰出青年学者奖”、2002年获 “甘肃省科技进步一等奖”等。
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主页访问
7530
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关注数
0
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成果阅读
403
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成果数
10
涂永强, Yan Xing Jia, †, Bin Wu, Xin Li, Shi Kuo Ren, Yong Qiang Tu, *, Albert S. C. Chan, ‡, and William Kitching§
Org. Lett., Vol. 3, No 6, 2001,-0001,():
-1年11月30日
The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1
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涂永强, Bao Min Wang, Zhen Lei Song, Chun An Fan, Yong Qiang Tu, *, and Yian Shi†
Org. Lett., Vol. 4, No.3, 2002,-0001,():
-1年11月30日
A new Lewis acid promoted rearrangement reaction of 2,3-aziridino alcohols was discovered, which involved the highly stereoselective construction of a diastereogenic quaternary carbon center and efficient formation of
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涂永强, Lei Shi, Min Wang, Chun-An Fan, Fu-Min Zhang, and Yong-Qiang Tu*
Org. Lett., Vol. 5, No.19, 2003,-0001,():
-1年11月30日
A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho- or para-substituted phenylhalides. In addition, a mechanism via the interesting benzyne intermediate has been proposed.
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涂永强, Zhen Lei Song, Bao Min Wang, Yong Qiang Tu, *, Chun An Fan, and Shu Yu Zhang
Org. Lett., Vol. 5, No.13, 2003,-0001,():
-1年11月30日
A short and general approach to the cis-3a-aryloctahydroindole alkaloids has been developed on the basis of a key stereocontrolled ZnBr2-catalyzed rearrangement of 2,3-aziridino alcohols. Two representative members, (
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涂永强, Lei Shi, Yong-Qiang Tu, *, Min Wang, Fu-Min Zhang, and Chun-An Fan
Org. Lett., Vol. 6, No.6, 2004,-0001,():
-1年11月30日
An efficient three-component coupling of aldehyde, alkyne, and amine to generate propargylamines has been effected under microwave irradiation in water using only CuI catalyst without the noble metal cocatalyst. This method has proved to be applicable to a wide range of substrates. In addition, the preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.
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涂永强, Pei Nian Liu, Pei Ming Gu, Fei Wang, and Yong Qiang Tu*
Org. Lett., Vol. 6, No.2, 2004,-0001,():
-1年11月30日
Chiral Ru-TsDPEN [N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-derived catalysts were first successfully immobilized onto amorphous silica gel and mesoporous silicas of MCM-41 and SBA-15 by an easily accessible approach. The catalyst immobilized on silica gel demonstrated remarkably high catalytic activities and excellent enantioselectivities (up to>99% ee) for the heterogeneous asymmetric transfer hydrogenation of various ketones. Particularly, the catalyst could be readily recovered and reused in multiple consecutive catalytic runs (up to 10 uses) with the completely maintained enantioselectivity.
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涂永强, De Run Li, Wu Jiong Xia, Yong Qiang Tu, *, Fu Min Zhang, and Lei Shi
CHEM. COMMUN., 2003, 798-799,-0001,():
-1年11月30日
A novel and highly stereoselective tandem rearrangement-reduction reaction of 1-benzyloxy-2,3-epoxide, under the promotion of triethylaluminum (AlEt3), has been developed to construct a quaternary stereocenter and the hydroxymethyl attached to the carbon center in one-step.
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涂永强, Chun-An Fan, Xiang-Dong Hu, Yong-Qiang Tu, *. Bao-Min Wang, and Zhen-Lei Song[a]
Chem. Eur. J. 2003, 9, 4301-4310,-0001,():
-1年11月30日
A novel and highly diastereoselective samarium-catalyzed tandem rearrangement/reduction of secondary α-hydroxy epoxides, which involves a C1 to C3 carbon migration rearrangement and a very interesting hetero-Tishchenko reduction of the intermediate aldehyde and the reductant aldehyde, has been reported. This reaction could be developed to provide a facile and stereoselective construction of 2-quarternary 1,3-diol units with an hydroxymethyl moiety attached to the diastereogenic quaternary carbon center. Detailed investigations have been carried out concerning the screening of the aldehydes as a reductant, the optimization of reaction conditions, and the substrate scope of this tandem reaction. A catalytic cycle for this reaction, the electronic and steric effects of the reductant aldehydes, and the mechanism for the acyl migration of 1,3-diol monoesters are proposed.
alcohols, diastereoselectivity, rearrangement, samarium, Tishchenko reaction
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涂永强, Chun-An Fan, Bao-Min Wang, Yong-Qiang Tu, *, and, Zhen-Lei Song
Angew. Chem. Int. Ed. 2001, 40, No.20,-0001,():
-1年11月30日
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涂永强, Xiang-Dong Hu, Chun-An Fan, Fu-Min Zhang, and Yong Qiang Tu*
Angew. Chem. Int. Ed. 2004, 43, 1702-1705,-0001,():
-1年11月30日
alkylation, allylation, boron, rearrangement, substituent effect
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