赵康
抗可卡因、单克隆抗体、抗病毒研究和糖化学
个性化签名
- 姓名:赵康
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
生物化学工程
- 研究兴趣:抗可卡因、单克隆抗体、抗病毒研究和糖化学
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主页访问
2566
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关注数
0
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成果阅读
574
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成果数
9
【期刊论文】FDA New Drug Approvals in 2000
赵康, Kang Zhao, * John Reiner, ** and Weilin Xie
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-1年11月30日
In 2000, the FDA approved 26 new drug entities. This survey groups these therapeutics into four areas coded: (A) neurotransmitter analogs, (B) anti-ulcer and antiinflammation agents, (C) hormone-related drugs, and (D) antiinfectious drugs and miscellaneous molecules. Included in the synopsis for each compound is a description of the drug's benefits for a medical need, a mode of action if known, a chemical structure, and in most cases an abbreviated pathway outlining how the drug is synthesized.
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引用
赵康, Junbiao Chang, a Kang Zhaob, * and Shifeng Pana, *
Tetrahedron Letters 43(2002)951-954,-0001,():
-1年11月30日
The Schiff base derived from the condensation of o-aminophenol with benzaldehydes was induced to undergo oxidative cyclization in the presence of DDQ. The resulting 2-arylbenzoxazoles were separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion-exchange resin. The applicability of this chemistry to spatially separate library synthesis is demonstrated by the preparation of a 352-member library.
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赵康, by Songqing Wanga), Junbiao Changa), Shifeng Pan*a), b), and Kang Zhao*a)
,-0001,():
-1年11月30日
A series of novel 2'-fluoro-3'-[alkyl(hydroxy)amino]nucleoside analogs were prepared via conjugate addition of N-methylhydroxylamine to various 2-fluorobutenolides. The conjugate adducts 13a and 16 were obtained as single isomers under absolute control of stereochemistry. The crucial N-demethylation of the N-methylhydroxylamines 23-25 was readily achieved by means of DDQ oxidation, followed by nitrone/oxime exchange reaction. By this procedure, a variety of alkyl groups could be efficiently introduced at the 3'-N-atom of the nucleoside analogs, some of which might display potentially interesting anti-HIV properties.
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赵康, 何兰①赵康②*李文保②*
,-0001,():
-1年11月30日
“动态组合化学”(Dynamic Combinatorial Chemistry)利用分子自我组装的新方法形成“动态组合库”(Dynamic Combinatorial Library)。与传统组合化学技术相比,动态组合化学增加了“靶标模板”(Target Template)方法,模板的加入诱导了组合库内的分子组分的持续可逆的化学转化,产生新的组合库。该库的成份具有与模板相互作用的功能,有的成份是模板的最佳结合伙伴。如果建立的模板是为了筛选药物,这一技术可以应用于先导化合物(Lead Compounds)的发现过程。
动态组合化学 动态组合库 模板 模板配体
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121浏览
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【期刊论文】抗HIV和HBV病毒药物L-Fd4C及相关核苷类似物
赵康, 胡清萍①赵康②陈曙辉*②, ③
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-1年11月30日
在抗病毒研究过程中,核苷类型的RT抑制剂扮演着重要的角色。从经典的AZT到L-型核苷及至最近的磷酸前药,人们一直都在核苷的结构上大做文章,并逐渐认识到了L-型核苷的重要性。为了得到疗效更强,毒性更低的抗HIV、HBV的药,新的发展方向是对已有疗效比较好的化合物进行单磷酸化,使之能够在细胞内快速的变成三磷酸。随之需要解决的新问题,就是如何把磷酸盐变成中性的前药,以便进入细胞,然后在细胞内再变为有活性的磷酸盐。本综述讨论了几个L-核苷类似物的研究工作,对它们的合成、磷酸前药的研制方法、抗癌症的生物活性进行描述。
核苷酸 前药 抗病毒
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【期刊论文】抗HIV和HBV病毒药物L-Fd4C及相关核苷类似物
赵康, 胡清萍①赵康②陈曙辉*②, ③
,-0001,():
-1年11月30日
在抗病毒研究过程中,核苷类型的RT抑制剂扮演着重要的角色。从经典的AZT到L-型核苷及至最近的磷酸前药,人们一直都在核苷的结构上大做文章,并逐渐认识到了L-型核苷的重要性。为了得到疗效更强,毒性更低的抗HIV、HBV的药,新的发展方向是对已有疗效比较好的化合物进行单磷酸化,使之能够在细胞内快速的变成三磷酸。随之需要解决的新问题,就是如何把磷酸盐变成中性的前药,以便进入细胞,然后在细胞内再变为有活性的磷酸盐。本综述讨论了几个L-核苷类似物的研究工作,对它们的合成、磷酸前药的研制方法、抗癌症的生物活性进行描述。
核苷酸 前药 抗病毒
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【期刊论文】FDA New Drug Approvals in 2002
赵康, Boying Guo, Ru Bi, Kang Zhao* and John Reiner*
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-1年11月30日
This review covers the 17 new chemical entities approved by the Food and Drug Administration in the year 2002. Therapeutics are categorized into the following coded areas: (A) agents affecting neurotransmission, (B) anti-infectious agents, (C) anti-cancer agents, (D) hormone related agents, and (E) miscellaneous agents. Included in each drug section are a short description of its approved medical use, a mechanism of action if known, a chemical structure, and a pathway for its synthesis.
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【期刊论文】Efficient Synthesis of γ-DDB
赵康, Junbiao Chang, a, b* Xiaohe Guo, c Senxiang Cheng, b Ruiyun Guo, b Rongfeng Chen, b Kang Zhaoa*
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-1年11月30日
Synthesis of γ-DDB, which is the another family member of α-DDB (dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate), is described. The unsymmetric isomer (γ-DDB) was constructed by a linker-directed intramolecular Ullmann coupling reaction, followed by the cleavage of the linker and re-esterification.
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【期刊论文】Synthesis of polysubstituted dihydropyrroles and pyrroles from b-carbonyl O-methyloximes
赵康, Zhiquan Song, John Reiner and Kang Zhao*
Tetrahedron Letters xxx(2004)xxx-xxx,-0001,():
-1年11月30日
Polysubstituted 4,5-dihydropyrroles and pyrroles were synthesized from b-carbonyl O-methyloximes via alkylation and intramolecular Michael addition with unsaturated 4-bromobutyrates by treatment with sodium hydride or a sodium alkoxide.
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