周长忍
生物材料和组织工程支架材料的研究与开发,涉及生物降解材料、血液相容性材料、缓释控释材料、医用纳米材料以及生物材料的评价与表征等
个性化签名
- 姓名:周长忍
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师, “973”、“863”首席科学家, 优秀教师/优秀教育工作者
- 职称:-
-
学科领域:
材料科学基础学科
- 研究兴趣:生物材料和组织工程支架材料的研究与开发,涉及生物降解材料、血液相容性材料、缓释控释材料、医用纳米材料以及生物材料的评价与表征等
周长忍,男,教授,博士生导师,暨南大学首批特聘一级教授。1978.2~1981.12 在山东大学化学系高分子专业学习;1982.1~1990.8 在山东大学化学系任教;1990.8~1993.7 在中山大学学习,获博士学位;1993.7~2004.7 在暨南大学生命科技学院生物材料研究室工作;2004年7月至今在暨南大学材料系生物材料研究室工作。2006年起担任人工器官与材料教育部工程研究中心主任。自1993年以来一直从事生物材料和组织工程支架材料的研究与开发,涉及生物降解材料、血液相容性材料、缓释控释材料、医用纳米材料以及生物材料的评价与表征等,成绩显著。连续四次主持国家自然科学基金项目,同时承担了国家重点基础研究发展规划项目(973计划)和国家高技术研究发展计划(863计划)、省市级等多项高水平的研究。此外还有一项横向项目,所研究的“术后防粘连膜”已经进入临床前的研究阶段。
现担任中国生物医学工程学会理事,生物材料分会常务理事兼秘书长,广东省人体生物组织工程学会副会长,教育部2006~2010年度生物医学工程教学指导委员会委员,广东省材料研究会副理事长、《生物医学工程学杂志》编委、《广州化学》编委等。1995年被广东省遴选为“千百十工程”跨世纪人才。1998年获国务院侨办“科技成果三等奖”,1998年获国务院侨办高等学校“优秀教师”称号。2002年获教育部“优秀中青年骨干教师”。2006年分获教育部和广东省科技进步二等奖。主编《生物材料学》专著一部(中国医药科技出版社出版),作为副主编编写《药用高分子材料与现代药剂》(科学出版社出版),参加编写《组织工程实验技术》等。发表高水平学术论文110多篇,40多篇论文参加了国内外的学术交流,获批国家科技发明专利5项。
-
主页访问
2961
-
关注数
0
-
成果阅读
967
-
成果数
20
周长忍, Qian-ying
Pharmaceutical Biology 2006, Vol. 44, No. 5, pp. 336-342,-0001,():
-1年11月30日
Chitosan nanoparticles loaded with lysozyme were prepared by means of an ionic gelation process of chitosan (CS) and tripolyphosphate (TPP) on mild condition. Observations by TEM showed that the spherical chitosan nanoparticles were 50–280nm in diameter. This work focuses on the effects of molecular weight (Mv) of CS, content of CS, TPP, and initial lysozyme on encapsulation efficiency (EE), loading capacity (LC), release rate and activity of lysozyme in chitosan nanoparticles. Increasing Mv of chitosan, TPP content, or decreasing initial lysozyme content, EE was enhanced whereas when increasing chitosan content, EE first increased then decreased. LC increased as Mv of chitosan, content of TPP, or initial lysozyme increased or chitosan content decreased. The EE could be up to 47.3% and the LC could be 11.4%. The lysozyme release rate increased with decreasing the initial amount of lysozyme, Mv, or content of chitosan and increasing the amount of TPP. The relative activity of lysozyme in all the samples was maintained above 85%.
Chitosan,
-
78浏览
-
0点赞
-
0收藏
-
0分享
-
3852下载
-
0评论
-
引用
周长忍, Lihua
Journal of Applied Polymer Science, Vol. 91, 274-277 (2004),-0001,():
-1年11月30日
As
degradation,
-
78浏览
-
0点赞
-
0收藏
-
0分享
-
549下载
-
0评论
-
引用
周长忍, Yanpeng
Journal of Applied Polymer Science, Vol. 101, 1515-1521 (2006),-0001,():
-1年11月30日
Firstly,
biomaterials,
-
66浏览
-
0点赞
-
0收藏
-
0分享
-
479下载
-
0评论
-
引用
周长忍, Lihua
L. Li et al. Biomaterials 22 (2001) 2595-2599,-0001,():
-1年11月30日
Polysiloxane/liquid crystal composite membrane was first suggested to be used as biomaterials. In this work, the polydimethylmethyl hydrosiloxane and polydimethyl-methylethylenesilosiane, as a substrate, were blended with cholesteryloleyl carbonate (COC) in tetrahydrofuran, and then crosslinked into membranes on glass plates by means of the platinum catalyst at 110℃ for 20 min. The effects of the liquid-crystal content in composite membranes on the formation of liquid-crystal phase were verified by the observation of optical polarization microscopy. The relationship between the morphology of the composite membranes and blood compatibility was identified by the dynamicblood-clotting tests, haemolysis ratio measurement, platelet adhesion and SEM observation. The results show that the blood-compatibility of composite membranes with the concentration of liquid crystal 20, 30% (wt) is more excellent than that of other composite membranes.
Polysiloxane,
-
60浏览
-
0点赞
-
0收藏
-
0分享
-
123下载
-
0评论
-
引用
周长忍, CHANGREN
Eur. Polym. J. Vol. 34, No. 11, pp. 1663-1668, 1998,-0001,():
-1年11月30日
ÐA series of cis-polybutadiene(PB)/liquid crystal composite membranes, at several weight ratios, was prepared by casting from a tetrahydrofuran solution of cis-PB and three kinds of liquid crystal compounds (ABECA, ABEOA and ABMA), and then exposed to S2Cl2 vapor at room temperature for crosslinking. The e.ect of the composition of the membranes on the gas permeation has been investigated. The permeability coecient to O2 and N2 was much lower up to a liquid crystalline fraction of 30 wt% and in the case of a liquid crystalline fraction above 30 wt% it rose greatly. The influence of testing temperature on the permeability of the membranes was also investigated, and the results show that the permeability coecient towards gases, reveal a distinct jump in the vicinity of the crystal-liquid crystal phase transition temperature of liquid crystal compounds. It is noteworthy that the crystal-liquid crystal transition temperature (TKN) in the composite membranes was about 30℃ lowerthan that of the pure liquid crystal compound. The results suggested that the flexible chain of polymer is advantageous to reduce the TKN of liquid crystal compounds in composite membranes.
-
49浏览
-
0点赞
-
0收藏
-
0分享
-
105下载
-
0评论
-
引用
周长忍, Changren
C. Zhou, Z. Yi. Biomaterials 20 (1999) 2093-2099,-0001,():
-1年11月30日
Polyurethane/liquid
Polyurethane,
-
58浏览
-
0点赞
-
0收藏
-
0分享
-
129下载
-
0评论
-
引用
周长忍, Hua
H. Liu et al. Acta Biomaterialia 2 (2006) 557-565,-0001,():
-1年11月30日
was moldable because of its paste consistency after mixing. We used four groups of cement to investigate the mechanical properties and biocompatibility of the new biomaterial in vitro, which were named group A (10% citric acid), B (15% citric acid), C (20% citric acid) and D (25% citric acid). The setting times of the cements were 5–30 min. X-ray diffraction analysis showed that the products were hydroxyapatite (HA) and dicalcium phosphate anhydrous. When the concentration of citric acid was increased, the compressive strength of specimen increased. Through the simulated body fluid test, we observed the material was bioactive. Group D could induce Ca and P ions to deposit the surface group D quickly. These results indicated that the concentration of citric acid in the liquid component affected the mechanical properties and bioactivity of cements. The cell cultivation test showed that the cytocompatibility of the new biomaterial was good. The method for preparing the novel bone substitute material is simple. The starting material is more readily available and cheaper than HA, poly(methyl methacrylate), and so on. The cement could have good prospects for medical application.
Calcium
-
46浏览
-
0点赞
-
0收藏
-
0分享
-
184下载
-
0评论
-
引用
周长忍, Yanpeng
,-0001,():
-1年11月30日
To combine the individual advantages of synthetic and natural polymers, poly(L-lactic acid) (PLLA)–chitosan hybrid scaffolds were fabricated. PLLA sponges were prepared by particulate-leaching, and then PLLA–chitosan hybrid scaffolds were obtained by dipping the PLLA sponges in chitosan solution and subsequently freeze–drying. Physicochemical properties of the scaffolds were characterized by scanning electron microscopy (SEM), water uptake test, and mechanical strength measurement. Moreover, cell adhesion, cell proliferation, and cell viability on the scaffolds were evaluated through osteoblast-like cell culture. The experimental results indicated that, PLLA sponges exhibited macroporous structure and the interconnected microporous structure of chitosan was formed within the macropores of PLLA sponges. The incorporation of chitosan reinforced PLLA sponges in dependence on chitosan content. The hybrid scaffolds had higher water uptake ability compared with PLLA sponges. Particularly, the hybrid scaffolds exhibited excellent cell attachment efficiency, cell proliferation, and cell viability. This study suggests that the hybrid scaffolds obtain good mechanical strength from PLLA and excellent cell compatibility from chitosan.
biomaterials,
-
75浏览
-
0点赞
-
0收藏
-
0分享
-
170下载
-
0评论
-
引用
周长忍, 焦延鹏, 李立华
中国生物医学工程学报2005年6月第24卷第3期/Chinese Journal of Biomedical Engineering June., 2005, Vol. 24, No. 3,-0001,():
-1年11月30日
本研究在制备了一系列可降解的三乙烯基交联剂的基础上,利用偶氮二异丁氰(AlBN)引发该交联剂与N-乙烯基吡咯烷酮(NVP) 交联。重点研究了交联剂含量及分子量对材料的吸水率、接触角利降解性能的影响。结果表明交联膜材料的接触角随着交联剂含量的增加而逐渐增加,而吸水率和材料的降解速率却逐渐减小;随交联剂分子量的增加,材料的吸水率是逐渐增加但对接触角的影响不大,材料的降解速率随交联剂分子量的增加而增大。
生物降解交联剂, 交联, PVP 膜材料, 性能
-
67浏览
-
0点赞
-
0收藏
-
0分享
-
115下载
-
0评论
-
引用
周长忍, 焦延鹏, 黄静雯, 李立华
材料研究学报2004年10月第18卷第5期/CHINESE JOURNAL OF MATERIALS RESEARCH October 2004, Vol. 18, No. 5,-0001,():
-1年11月30日
合成了一种具有双烯丙基的聚乙二醇和聚乳酸三嵌段共聚物(PLA-b-PEG-b-PLA)的生物可降解交联剂,并以偶氮二异丁氰(AIBN)为引发剂与N-乙烯基吡咯烷酮(NVP)交联制备了一种新型可降解交联膜材料。研究了丙交酯和PEG的投料比对交联剂粘度的影响和交联剂含量和分子量对膜材料的吸水率、接触角和力学强度的影响,初步研究了交联膜材料的降解性能。结果表明:随着丙交酯含量的增加,交联剂的特性粘度增加;随着交联剂含量的增加,膜材料的吸水率减小,接触角增大,拉伸模量增加,断裂伸长率先增加后减小;随着交联剂分子量的增加,膜材料的吸水率和接触角均有增加;对降解性能的研究表明,在降解初期膜材料的质量损失率线性地增加,在降解后期剧烈增加。
有机高分子材料, 生物材料, 生物降解, 交联PVP, 性能
-
34浏览
-
0点赞
-
0收藏
-
0分享
-
42下载
-
0评论
-
引用