王平
人工嗅觉与人工味觉和细胞生物传感器的基础性和应用基础的研究,并在医学诊断、药物分析和环境检测等领域中进行了开拓性和创新性的研究工作
个性化签名
- 姓名:王平
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师
- 职称:-
-
学科领域:
临床诊断学
- 研究兴趣:人工嗅觉与人工味觉和细胞生物传感器的基础性和应用基础的研究,并在医学诊断、药物分析和环境检测等领域中进行了开拓性和创新性的研究工作
王平,主要学术兼职:美国纽约科学院成员;中国电子学会离子敏、生物敏专业委员会副主任;中国生物医学工程学会生物医学传感技术学会副主任;中国仪器仪表学会传感器分会常务理事;中国生物医学工程学会生物医学测量学会委员;国际刊物”Biosensors & Bioelectronics”审稿人;”Sensors & Actuators B”以及”Measurement Science & Technology”审稿人;“传感技术学报”编委、“仪表技术与传感器”编委,“浙江大学学报(工学版)编委”、“国外医学生物医学工程分册”编委等。 二、主要学术成绩:从1993年开始,申请人在国家博士后科学基金、国家自然科学基金、国家自然科学基金委国际合作项目、国家教育部骨干教师资助计划项目、国家教育部博士点基金和国家“863”高科技等项目的连续支持下,在国际上较早开展了人工嗅觉与人工味觉和细胞生物传感器的基础性和应用基础的研究,并在医学诊断、药物分析和环境检测等领域中进行了开拓性和创新性的研究工作。申请人采用电子信息技术与生物医学相结合的手段,以生物嗅觉和味觉的神经生理学为基础,提出了仿生传感器设计思想、结合新型嗅觉和味觉的功能材料、微结构集成嗅觉和味觉传感器的设计、现代数字信号处理和仪器设计技术等,为人工嗅觉与人工味觉和细胞传感器的实际应用提供了重要的理论依据。另一方面,申请人在结合电子技术和生物技术,在国际上较早开展了细胞传感器及细胞传感器网络的基础研究。申请人在上述领域中主持完成了国家级和省部级项目10余项、作为第一完成人获得国家自然科学基金委优秀研究成果3项、浙江省科学技术奖二等奖1项、浙江省高校科研成果一等奖1项、浙江省科技厅的技术鉴定1项、获得中国传感器技术学会和中国电子学会优秀论文奖3项、获得浙江省科委优秀论文奖(二等奖)4项。申请人入选国家新世纪百千万人才工程第一、二层次候选人,国家教育部骨干青年教师培养计划、浙江省跨世纪学术和技术带头人培养规划(151人才工程)第一层次、获得首届中国仪器仪表学会奖学金二等奖;浙江大学优秀青年教师一等奖。近5年来出版学术著作3部,SCI收录论文14篇、EI收录论文11篇、国内一级刊物9篇、ISTP收录20余篇,SCI他人引用论文49篇次、国家发明专利8项、国家实用新型专利4项。
-
主页访问
2864
-
关注数
1
-
成果阅读
225
-
成果数
5
【期刊论文】A novel method for wine analysis based on sensor fusion technique
王平, Li Rong, Wang Ping *, Hu Wenlei
Sensors and Actuators B 66(2000)246-250,-0001,():
-1年11月30日
A novel method for wine analysis based on sensor fusion technique is proposed in this paper. Our novel method is a trial of realizing an engineering model of the sensing and recognizing systems of humans that combines all features of artificial olfactory and artificial taste, i.e. 'electronic nose' and 'electronic tongue' for the classification of wine. Moreover, we improved a kind of fuzzy neural network for sensor information fusing. The results show that the above methods have the characteristics of better accuracy, convenience and efficiency. q2000 Elsevier Science S.A. All rights reserved.
Wine analysis, Electronic nose, Electronic tongue
-
36浏览
-
0点赞
-
0收藏
-
0分享
-
294下载
-
0评论
-
引用
【期刊论文】Drug evaluations using a novel microphysiometer based on cell-based biosensors
王平, Wu Yicong a, Wang Ping a, *, Ye Xuesong a, Zhang Gaoyan a, He Huiqi a, Yan Weimin a, Zheng Xiaoxiang a, Han Jinghong b, Cui Dafu b
Sensors and Actuators B 80(2001)215-221,-0001,():
-1年11月30日
This paper presents a novel microphysiometer based on cell-based biosensors for simultaneous measurements of several extracellularion concentrations in living cells when treated with drugs. It can measure the extracellular acidification rate (ECAR) under the effects of the drug. Thus the relation between the cells metabolism and the activity of receptors can be explored, and the function of the drug can be analyzed. We used our system to measure the effects of some drugs on the nephridium and cardiac muscle cells of the suckling rat. As the microphysiometer works under regular cell culture conditions, cells can be repeatedly simulated with drugs to complete dose-response curve within a few hours. With the detection of a general parameter (extruded protons and ions), the system can be used to monitor the realtime process of the cells metabolism, observe the functional responses of different kinds of membrane-bound receptors and evaluate the drugs.
Cell-based biosensors, Microphysiometer, Cellular acidification rate, Drugs e, v, a, l, uating
-
68浏览
-
0点赞
-
0收藏
-
0分享
-
163下载
-
0评论
-
引用
【期刊论文】A novel design of multi-light LAPS based on digital compensation of frequency domain
王平, Zhang Qintao a, Wang Ping b, *, Wolfgang J. Parak c, Michael George c, Gaoyan Zhang b
Sensors and Actuators B 73(2001)152-156,-0001,():
-1年11月30日
In this report, a method which can significantly increase the measurement rate of the light-addressable potentiometric sensor (LAPS) is suggested. By illuminating the LAPS simultaneously at several positions, of which each is illuminated with a light pointer modulated with a different frequency, the surface potential at all illuminated regions can be measured simultaneously by analyzing the resulting photocurrent. By using this method, the rate to obtain a complete image of the surface potential distribution across a LAPS wafer can be drastically increased compared to the conventional mode, in which images are obtained by scanning the surface with one single light pointer. The technical feasibility of such a device is discussed and test measurements are presented.
Light-addressable potentiometric sensor (, LAPS), , Multi-light LAPS, Surface potential sensor, Spatial resolution, Digital compensation, Frequency division multiplexing (, FDM),
-
48浏览
-
0点赞
-
0收藏
-
0分享
-
235下载
-
0评论
-
引用
王平, Gaixia Xu, Xuesong Ye, Lifeng Qin, Ying Xu, Yan Li, Rong Li, Ping Wang ∗
Biosensors and Bioelectronics xxx(2004)xxx-xxx,-0001,():
-1年11月30日
Cell-based biosensors incorporate cells as sensing elements that convert changes in immediate environment to signals for processing. This paper reports an investigation on light-addressable potentiometric sensor (LAPS) to be used as a possible cell-base biosensor that will enable us to monitor extracellular action potential of single living cell under stimulant. In order to modify chip surface and immobilize cells, we coat a layer of poly-l-ornithine and laminin on surface of LAPS chip on which rat cortical cells are grown well. When 10 μg/ml acetylcholine solution is administrated, the light pointer is focused on a single neuronal cell and the extracellular action potential of the targeted cell is recorded with cell-based biosensor based on LAPS. The results demonstrate that this kind of biosensor has potential to monitor electrophysiology of living cell non-invasive for a long term, and to evaluate drugs primarily.
Single living cell, Cell-based biosensor, Light-addressable potentiometric sensor, Extracellular action potential
-
38浏览
-
0点赞
-
0收藏
-
0分享
-
141下载
-
0评论
-
引用
【期刊论文】A novel microphysiometer based on MLAPS for drugs screening
王平, Wu Yicong, Wang Ping *, Ye Xuesong, Zhang Qingtao, Li Rong, Yan Weimin, Zheng Xiaoxiang
Biosensors & Bioelectronics 16(2001)277-286,-0001,():
-1年11月30日
This paper presents a novel microphysiometer for simultaneous measurements of several extracellular ions concentrations in living cells based on MLAPS (multi-light addressable potentiometric sensor). In the microphysiometer, different sensitive membranes are illuminated in parallel with n light sources at different frequencies, the response amplitudes of each frequency component can be measured on-line by parallel processing algorithm. By the experiments, we can analyze the relations of the extracellular environmental H+, Na+, K+, Ca2+ under the effects of western medicines (dilantin, phenobarbital sodium, penicillin sodium) and Chinese drugs (scutellaria, medlar, hemlock parsley), and estimate the effects of several drugs. As the novel microphysiometer works under regular cell culture conditions, cells can be repeatedly simulated with drugs to complete dose-response curve within a few hours. With the detection of a general parameter (extruded protons and ions), the system can be used to monitor the real-time process of the cells' metabolism, observe the functional responses of different kinds of membrane-bound receptors, evaluate the drugs.
Drugs screening, K+, , Ca2+, , Microphysiometer, MLAPS
-
35浏览
-
0点赞
-
0收藏
-
0分享
-
195下载
-
0评论
-
引用