江云宝
在荧光探针法和光诱导质子/电子转移荧光传感与分子识别方面开展了独立、系统的研究工作。
个性化签名
- 姓名:江云宝
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学术头衔:
博士生导师
- 职称:-
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学科领域:
分析化学
- 研究兴趣:在荧光探针法和光诱导质子/电子转移荧光传感与分子识别方面开展了独立、系统的研究工作。
江云宝,男,1963年11月生于安徽。1990年获厦门大学理学博士学位(导师:陈国珍教授)后留校任教,分别于1992年和1995年破格晋升为副教授和研究员,1996年被遴选为博士生导师。1994至95年受国家教委资助在德国马普生物物理化学研究所高访;96至97年在香港大学支志明院士实验室从事大学博士后研究;97至98年获德国洪堡基金,在马普生物物化所开展合作研究,并获得洪堡基金会资助价值达6万马克的纳秒荧光寿命测量仪(通常资助额约2万马克);2000年11月至01年1月获德国国家科学基金会资助在马普生物物化所合作研究。曾获中国化学会青年化学奖、第五届中国青年科技奖、国家教委科技进步三等奖(第一获奖人)、霍英东基金会高校青年教师奖、福建“运盛”青年科技奖、国务院政府特殊津贴、教育部高校青年教师奖和德国大众基金会研究基金。应邀参加国家教委首届部分领域高校优秀年轻专家科技研讨会和国家基金分析化学学科“十五”发展战略研讨会;应约为“J. Am. Chem. Soc.”, “J. Phys. Chem.”, “J. Org. Chem.”, “Org. Lett.” 等多种学术期刊和国家基金等担任通讯评议人;2001年任《光谱学与光谱分析》编委;02年当选中国化学会理事;现任厦门大学化学化工学院副院长,分析科学教育部重点实验室副主任、学术委员会委员。先后主持德国Humboldt基金、Volkswagen基金,国家、教育部和福建省科学基金项目15项,在荧光探针法和光诱导质子/电子转移荧光传感与分子识别方面开展了独立、系统的研究工作。发展了表征环糊精和胶束等超分子有序介质微环境性质的荧光探针分析法,主要结果获得国家教委科技进步三等奖(1997);将激发态分子内电荷转移光物理引入分析化学,设计合成了具有分析化学应用前景的十余类300多种分子内电荷转移(ICT)荧光体,系统研究了ICT光物理性质与分子结构和介质性质等物理量的关系,并巧妙地构建了将该关系转化为与化学物质量的关系的“偶合桥梁”,以适于分析化学应用;理论上建立并实验验证了ICT荧光发射能量与电子给体/受体上取代基常数之间的线性自由能关系,指导荧光传感体系中含识别位点的电子给体/受体的结构设计;在此基础上建立了具有生命科学意义的阴离子、金属离子和糖等中性分子的ICT双重荧光传感和分子识别方法;近年更发展了N-苯胺基和N-酰胺基硫脲类变构型基态ICT阴离子受体,阴离子结合时诱导受体分子构型变化、触发基态ICT,吸收光谱巨变、阴离子结合常数显著提高,部分体系中已实现阴离子的选择性“裸眼”检测。先后于“Org. Lett.”, “J. Phys. Chem.”, “J. Org. Chem.”, “Chem. Phys. Lett.”, “中国科学”等重要学术期刊发表论文100多篇(其中SCI论文72篇),被他引290多篇次,并应JACS副主编E. V. Anslyn 教授之邀为“Tetrahedron”的“Symposium-in-Print”专集“Synthetic Receptors in Sensing Applications”撰文。
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【期刊论文】A Novel Thiourea-Based Dual Fluorescent Anion Receptor with a Rigid Hydrazine Spacer
江云宝 , Fang-Ying Wu, †, ‡ Zhao Li, † Zhen-Chang Wen, † Ning Zhou, † Yu-Fen Zhao, † and Yun-Bao Jiang*
Org. Lett, Vol. 4, No.19, 2002,-0001,():
-1年11月30日
A neutral receptor with a rigid hydrazine spacer, N-p-(dimethylamino) benzamido-N
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江云宝 , Xuan Zhang, † Lin Guo, † Fang-Ying Wu, †, ‡ and Yun-Bao Jiang*
Org. Lett, Vol. 5, No.15, 2003,-0001,():
-1年11月30日
A substantially red-shifted fluorescence emission in 3-hydroxyl-2-naphthanilide in acetonitrile was developed and drastically enhanced upon addition of anions such as F-, AcO-, and H2PO4-, with the enhancement depending on anion basicity. Excited-state intermolecular proton transfer in the sensor-anion hydrogen-bonding complex was suggested to be the signaling mechanism.
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江云宝 , Xuan Zhang, † Chao-Jie Wang, ‡ Li-Hong Liu, † and Yun-Bao Jiang*, †
J. Phys. Chem. B 2002, 106, 12432-12440,-0001,():
-1年11月30日
p-Dimethylaminobenzanilides with a para or meta substituent at the amido anilino moiety were designed to generate a series of dual fluorescent molecules of variable electron acceptors. Ab initio calculations indicated that the anilino substitution did not lead to an obvious change in the ground-state structures of the fluorophores, and the 1H NMR signal of the amido -NH proton was found to experience a linear downfield shift with increasing σ of the substitutent, supporting the fact that the amido anilino moiety was indeed varied comparably by the substitution. The intramolecular charge transfer dual fluorescence was indeed observed in solvents over a large polarity range from the nonpolar cyclohexane (CHX) through diethyl ether (DEE) and tetrahydrofuran (THF) to highly polar acetonitrile (ACN). It was found that the CT emission shifted to the blue with increasing electron-withdrawing ability of the amido anilino substituent up to a Hammett onstant ó of ca. +0.39 and to the red at higher σ. The solvent polarity variation did not change the ó value at which the CT emission shift direction reverses. Similar variation profiles were also observed with the CT to LE emission intensity ratio and the total fluorescence quantum yield. It was concluded that the CT direction in p-dimethylaminobenzanilides was reversed by the amido anilino substitution, and the CT occurs from amido anilino to benzoyl moiety at low σ, whereas at high σ, the CT switches to that from dimethylamino to the benzanilide moiety, which was also supported from the Hartree-Fock calculations. This finding provides an alternative method based on substitutent effect for identifying the charge-transfer direction in multiple chargetransfer systems. The results suggested that the anilino group could be a much stronger electron donor than an aliphatic amino group, which would be of use in designing electron donor substituted molecules. In both cases the dependences of the CT emission energy against σ of the substituent at the amido aniline phenyl ring were found to be much stronger than that in the ester counterparts of p-dimethylaminobenzanilides. This interesting σ dependence in the CT emission would be of ignificance in developing new fluorescent sensors based on electron donor/acceptor variations in p-dimethylaminobenzanilides.
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江云宝 , Xuan Zhang, † Xiang-Ying Sun, †, ‡ Chao-Jie Wang, § and Yun-Bao Jiang*
J. Phys. Chem. A 2002, 106, 5577-5581,-0001,():
-1年11月30日
A series of benzoyl para- and meta-substituted benzanilides (BAs) and N-methylbenzanilides (MBAs) were synthesized and their absorption and fluorescence spectra in nonpolar solvent cyclohexane were investigated. Quantum mechanical calculations indicated that the ground state BAs existed preferentially in the trans configuration, whereas MBAs existed in the cis configuration, and benzoyl substitution hardly changed the ground-state structure in the same series. It was observed that all of the synthesized compounds displayed dual fluorescence in cyclohexane, i.e., a normal emission at ca. 330 nm and an abnormal long-wavelength fluorescence at around 500nm. Although the normal emission of both BAs and MBAs did not show obvious variation, the long-wavelength emission shifted strongly to the red with increasing electron-withdrawing ability of the substituent at the benzoyl moiety. The emission energies of the long-wavelength fluorescence of BAs and MBAs in cyclohexane were found to vary linearly with the Hammett substituent coefficient
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江云宝 , Yun-Bao Jiang, * Xiu-Juan Wang, and Li Lin
J. Phys. Chem. 1994, 98, 12367-12372,-0001,():
-1年11月30日
The fluorescence emission of 4-(dimethy1amino)chalcone (DMAC) in ionic micellar solutions is examined and discussed in a three-state (E*, A*, and P*) dynamic scheme in an attempt to investigate the formation of the photoinduced biradical state P* in micelles. The emission of DMAC in micelles is mainly from state A* with some from state E*. An extraordinarily high enhancement of the DMAC emission in micelles is observed when in comparison with that of a TICT (twisted intramolecular charge transfer) fluorophore whose excited state consists of two states, LE (locally excited state) and TICT, which correspond to states E* and A*, respectively, while the absorption of DMAC is only slightly strengthened in micelles. The formation of state P* is shown to be restricted in micelles through the blocking of the twisting of the double bond by the high viscosity in the micellar phase. The medium polarity appears to play a relatively minor role in the formation of state P*. The micellar interfacial electric field also exerts an effect, a stronger electric field, favoring the formation of state P*. The dramatic enhancement of the DMAC emission in micelles makes DMAC a potential and feasible fluorescent probe for micelle formation.
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江云宝 , Li Nie, †, ‡ Zhao Li, † Jie Han, † Xuan Zhang, † Rui Yang, § Wen-Xia Liu, † Fang-Ying Wu, ┴ Jian-Wei Xie, # Yu-Fen Zhao, † and Yun-Bao Jiang*
J. Org. Chem. 2004, 69, 6449-6454,-0001,():
-1年11月30日
A series of neutral N-(substituted-benzamido)-N-phenylthioureas (substituent=p-OC2H5, p-CH3, m-CH3, H, p-Cl, p-Br, m-Cl, and p-NO2) were designed as anion receptors, in which the thiourea binding site was attached to the benzamido moiety via an N-N bond. The absorption spectra of these N-benzamidothioureas in acetonitrile peaked at ca. 270nm were found to show unprecedented red shifts by 7373 to 14325cm-1 in the presence of anions such as AcO-, F-, and H2PO4-. Under the same conditions, the classic neutral thiourea receptors, N-(substituted-phenyl)-N-phenylthioureas, showed absorption spectral shifts in most cases of less than 800 cm-1 with one exception of 6501cm-1. Control experiments, effects of protic solvent, and 1H NMR titration confirmed the formation of hydrogen-bonding complexes between the new N-benzamidothiourea receptors and anions. The binding constants with AcO-, for example, are at 105-107mol-1 L order of magnitude, which are 13 to 590 times those of the corresponding classic N-phenylthioureas in the same solvent. It was found that, whereas the absorption of the N-benzamidothiourea receptors showed essentially no dependence on the substituent, the substantially red-shifted new absorption band of the N-benzamidothiourea-anion binding complex was sensitively subject to the substituent. A linear relationship was found between the absorption energies of the N-benzamidothiourea-acetate binding complexes and the Hammett constants of the substituents with a negative slope of -0.34 eV. This led to the assignment that the substantially red-shifted absorption band was the groundstate intramolecular charge-transfer absorption with the substituent locating in the electron acceptor moiety. It was concluded that anion binding to the thiourea moiety of the N-benzamidothiourea receptors switched on their ground-state charge transfer. An anion-binding induced structural change was suggested to occur around the N-N bond in N-benzamidothioureas, which resulted in a substantially increased electron donating ability of the electron donor in the receptor molecules. As a consequence, the ground-state charge transfer takes place in the N-benzamidothiourea-anion binding complexes, leading to unprecedented red shifts in the absorption spectra and substantially enhanced anion binding affinities than those of the corresponding N-phenylthiourea receptors. N-Benzamido-N-phenylthioureas represent a new generation of neutral thiourea-based anion receptors that show substantially improved anion binding performance important for anion sensing and recognition.
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【期刊论文】Photophysics of 1-dimethylaminonaphthalene in aqueous-organic binary solvents
江云宝 , Hong Chen, Yun-Bao Jiang)
Chemical Physics Letters 325(2000)605-609,-0001,():
-1年11月30日
Fluorescence and absorption spectra of 1-dimethylaminonaphthalene DMAN.in aqueous-organic binary solvents were recorded as a function of the content of organic components methanol, ethanol, n- and i-propanol, and acetonitrile.for the purpose of understanding the photophysics of DMAN. Whereas the absorption spectra underwent minor change with increasing organic component, the fluorescence spectra experienced a continuous blue-shift in the band position and the fluorescence quantum yield increased reaching a maximum before continuous decrease. It was found that, in a series of aqueous-organic binary solvents, the variations of the quantum yield versus solvent polarity turned at nearly the same solvent polarity equivalent to an ET (30). value of ca. 57 kcalmol-1. It is hence suggested that while the emissive state is intramolecular charge transfer in nature, the radiationless decay channel is solvent-polarity dependent.
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江云宝 , Fang-Ying Wu a, b, Yun-Bao Jiang a, *
Chemical Physics Letters 355(2002)438-444,-0001,():
-1年11月30日
The intramolecular charge transfer (ICT) dual fluorescence of p-dimethylaminobenzamide (DMABA) in acetonitrile was found to show highly sensitive response to HSO-4 over several other anions such as H2PO-4, AcO- and ClO-4. In the presence of bisulfate anion the dual fluorescence intensity ratio and the total intensity of DMABA decreased while the dual emission band positions remained unchanged. Absorption titration indicated that a 1:1 hydrogen bonding complex was formed between bisulfate anion and DMABA, which gave a binding constant of 2: 02
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江云宝 , Wei Huang, Xuan Zhang, Li-Hua Ma, Chao-Jie Wang, Yun-Bao Jiang *
Chemical Physics Letters 352(2002)401-407,-0001,():
-1年11月30日
A series of substituted-phenyl p-dimethylaminobenzoates with para- or meta-substitution at the ester phenyl ring (p-OH, p-CH3, H, p-Br, m-Cl, and p-NO2) were synthesized and their fluorescence spectra were recorded. Intramolecular charge transfer (CT) dual fluorescence was observed in polar solvents. The CT emission in the same solvent was found to shift to lower energy with increasing electron-withdrawing ability of the substituent, whereas the locally excited (LE) emission hardly showed any change. A linear correlation was found between the CT emission energies of the four of the six esters and the Hammett constants of the substituents in diethyl ether, tetrahydrofuran and ethyl acetate and the linear slopes were -0.190, -0.169 and -0.138 eV, respectively, that decreased with increasing solvent polarity. The implications of the present findings were discussed in terms of structural relaxation during the excited-state CT reaction and of designing new fluorescence chemosensors.
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江云宝 , Li-Hua Ma a, Zhao-Bin Chen b, *, , Yun-Bao Jiang a
Chemical Physics Letters 372(2003)104-113,-0001,():
-1年11月30日
4-(N-phenylamino)benzoic acid (PhABA) was synthesized and its fluorescence spectra were recorded. In aprotic polar solvents, PhABA emitted strongly Stokes-shifted single-banded fluorescence with practically the same wavelength as that of 4-(N,N-diphenylamino)benzoic acid (DPhABA), indicative of the ICT character of the emissive state. 4-(Nisopropylamino) benzoic acid (iPrABA) showed single band emission however, sluggish response to the solvent polarity. In alkanols dual fluorescence of PhABA and DPhABA was observed but with different dependencies on alkanol structures. We concluded that ICT occurring with PhABA was due to the N-phenyl/amino conjugation effect. The work could be of help in understanding speciality of anilino moiety as electron donor compared to aliphatic amino group.
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