屈良鹄
生物分子系统演化和RNA基因的结构和功能
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- 姓名:屈良鹄
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博士生导师
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学科领域:
生物化学
- 研究兴趣:生物分子系统演化和RNA基因的结构和功能
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【期刊论文】Mitogenomic Perspectives on the Origin and Phylogeny of Living Amphibians
屈良鹄, PENG ZHANG, HUI ZHOU, YUE-QIN CHEN, YI-FEI LIU, AND LIANG-HU QU
Syst. Biol. 54 (3): 391~400, 2005,-0001,():
-1年11月30日
Establishing the relationships among modern amphibians (lissamphibians) and their ancient relatives is necessary for our understanding of early tetrapod evolution. However, the phylogeny is still intractable because of the highly specialized anatomy and poor fossil record of lissamphibians. Paleobiologists are still not sure whether lissamphibians are monophyletic or polyphyletic, and which ancient group (temnospondyls or lepospondyls) is most closely related to them. In an attempt to address these problems, eight mitochondrial genomes of living amphibians were determined and compared with previously published amphibian sequences.Acomprehensive molecular phylogenetic analysis of nucleotide sequences yields a highly resolved tree congruent with the traditional hypotheses (Batrachia). By using a molecular clock-independent approach for inferring dating information from molecular phylogenies, we present here the first molecular timescale for lissamphibian evolution, which suggests that lissamphibians first emerged about 330 million years ago. By observing the fit between molecular and fossil times, we suggest that the temnospondyl-origin hypothesis for lissamphibians is more credible than other hypotheses. Moreover, under this timescale, the potential geographic origins of the main living amphibian groups are discussed: (i) advanced frogs (neobatrachians) may possess an Africa-India origin; (ii) salamanders may have originated in east Asia; (iii) the tropic forest of the Triassic Pangaea may be the place of origin for the ancient caecilians. An accurate phylogeny with divergence times can be also helpful to direct the search for "missing" fossils, and can benefit comparative studies of amphibian evolution. [Amphibian; mitochondrial genome; molecular dating; phylogeny; timescale.]
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【期刊论文】Identification of 20 microRNAs from Oryza sativa
屈良鹄, Jia-Fu Wang, Hui Zhou, Yue-Qin Chen, Qing-Jun Luo and Liang-Hu Qu*
1688~1695 Nucleic Acids Research, 2004, Vol. 32, No.5,-0001,():
-1年11月30日
MicroRNAs (miRNAs) are present in both plant and animal kingdoms and represents a growing family of non-coding RNAs. These tiny RNAs act as small guides and direct negative regulations usually in the process of development through sequence complementarity to target mRNAs. Although a large number of miRNAs have been identified from various animals, so far plant miRNA studies have focused mainly on Arabidopsis. Here we describe the identifcation of 20 miRNAs from a rice cDNA library. All the miRNAs were presumably processed from precursors with stem-loop structures and were positively detected in rice cells from at least one tissue, some of which showed tissue-specific expression. Twenty-three unique rice genes were identified to be feasible targets for seven rice miRNAs, including four members of Scarecrow-like transcription factor, the targets of miR-39 that had been characterized in Arabidopsis. Lacking long complementarity, the regulatory targets of 13 miRNAs remain to be further investigated. A possible mechanism of translational repressor for plant miRNAs that lack perfect complementarity to target mRNAs is discussed.
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