黄培强
主要从事有机合成化学研究,包括:合成方法学,不对称合成、药物、生理活性天然和拟天然产物的不对称合成。
个性化签名
- 姓名:黄培强
- 目前身份:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
有机化学
- 研究兴趣:主要从事有机合成化学研究,包括:合成方法学,不对称合成、药物、生理活性天然和拟天然产物的不对称合成。
黄培强,男,1982 毕业于厦门大学化学系,获学士学位;1983-1987在法国国家科研中心、天然产物化学研究所(C.N.R.S.―I.C.S.N.)攻读博士学位,1987年获法国南巴黎大学博士学位;1988-1990在中科院上海有机化学研究所博士后;1990起在厦门大学化学工作。1996年获国家杰出青年科学基金, 1992年,获中国化学会优秀青年化学奖,1997年获香港“求是”科技基金会“杰出青年学者奖”; 2002年获省优秀专家称号。现为化学化工学院院长。主持国家杰出青年科学基金、国家自然科学基金重点项目、参加国家自然科学基金“十五”重大项目、霍英东教育基金会高等院校青年教师基金和国家、教育部和福建省自然科学基金等十余个项目。已发表论文100余篇,其中SCI论文62篇,论文被他人引用288次。主要学术兼职: 中国化学会核心刊物《有机化学》杂志编委;《天然产物研究与开发》杂志编委;《厦门大学学报(自然科学版)》杂志编委;国家教委化学教育指导委员会、有机和高分子专业组成员(1995-2000);中国化学会常务理事、有机化学专业委员会委员;国家自然科学基金委员会第七、八、十届学科评审组成员(1998-1999,2000-2001,2004-)。应用有机化学国家重点实验室(兰州大学)、生物有机与分子工程教育部重点实验室(北京大学)学术委员会委员。
主要研究内容与特色: 主要从事有机合成化学研究,包括:合成方法学,不对称合成、药物、生理活性天然和拟天然产物的不对称合成。发展了多种用于生理活性含氮化合物和昆虫信息素不对称合成的方法。
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黄培强
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-1年11月30日
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黄培强
,-0001,():
-1年11月30日
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【期刊论文】DIBAL-H-H2NR and DIBAL-H-HNR1R2
黄培强 , Pei-Qiang Huang, * Xiao Zheng and Xian-Ming Deng
Tetrahedron Letters 42(2001)9039-9041,-0001,():
-1年11月30日
The reaction of a lactone or an ester with organoaluminum species generated from DIBAL-H-H2NR or DIBAL-H-HNR1R2
aminolysis, DIBAL-H, Weinreb amides, amides.,
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黄培强 , Pei-Qiang Huang, * Jun Deng
Synlett 2004, No. 2, 247-250,-0001,():
-1年11月30日
A flexible two-step asymmetric approach to N-protected (R)-5-alkyl tetramates and (R)-5-alkyl tetramic acid derivatives is described. The method is based on the diastereoselective alkylation of (R)-phenylglycinol derived tetramates 7 and 8, which are the first synthetic equivalents to chiral nonracemic tetramate 5-carbanionic synthons A.
asymmetric synthesis,, alkylations,, chiral auxiliaries,, tetramates,, tetramic acids
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【期刊论文】A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones
黄培强 , Ming-De Chen, Xiang Zhou, Ming-Zhu He, Yuan-Ping Ruan and Pei-Qiang Huang*
Tetrahedron 60(2004)1651-1657,-0001,():
-1年11月30日
Based on the use of (R)-p-benzyloxyphenylglycinol (10) as a new oxidatively cleavable chiral auxiliary, a flexible approach to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones via a diastereoselective reductive-alkylation is developed. The oxidative cleavage of the chiral auxiliary by CAN under mild conditions ensured the access to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones with ee at least 92%.
Isoindolin-1-one, Chiral auxiliary, Benzyloxyphenylglycinol, Asymmetric synthesis.,
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黄培强 , Jian-Feng Zheng, Li-Ren Jin, and Pei-Qiang Huang*
Org. Lett., Vol. 6, No. 7, 2004,-0001,():
-1年11月30日
Starting from (3R)-5-benzotriazolyl-3-phenylperhydropyrido[2,1-b][1,3]oxazole 9, the enantiodivergent syntheses of both enantiomers of the marine alkaloids haliclorensin 1 and isohaliclorensin 3 have been achieved. Our syntheses feature ring-expansion reactions for the formation of the aza-macrocycle ring system of 3 and sequential ring-expansion reactions (aza-Claisen rearrangement and Zip reaction) for the formation of the aza-macrocycle ring system of 1.
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黄培强 , Pei-Qiang Huang, * Hong-Qiao Lan, Xiao Zheng, and Yuan-Ping Ruan
J. Org. Chem., Vol. 69, No. 11, 2004,-0001,():
-1年11月30日
(2S,3S,7S)-3,7-Dimethylpentadecan-2-yl acetate (2) and its propionate analogue (3) are the main sex pheromones of all Neodiprion species and Diprion similes, respectively. Starting from (S)-malic acid and employing a highly chemo-, regio-, and stereoselective tandem ester reduction-epoxide formation-reductive epoxide-opening reaction protocol, an efficient total synthesis of (2S,3S,7S)-2 and -3 is reported herein.
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黄培强 , Bi-Yan He, Tian-Jun Wu, Xian-Yong Yu and Pei-Qiang Huang*
Tetrahedron: Asymmentry 14(2003)2101-2108,-0001,():
-1年11月30日
A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring antimicrobial (2R,3S)-2-aminotetradeca-5,7-dien-3-ol is reported. The method features a flexible and highly regioselective Grignard addition to (S)-malimide followed by a trans-diastereoselective reductive deoxygenation. The scope and limitations of the highly regio and diastereoselective reductive alkylation of malimides were defined. A remarkable protecting group effect on the regio and diastereoselective reductive alkylation of malimides was observed.
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【期刊论文】Asymmetric Synthesis of Antimalarial Alkaloids (+)-Febrifugine and(+)-Isofebrifugine
黄培强 , Pei-Qiang Huang, * Bang-Guo Wei, Yuan-Ping Ruan
Synlett 2003, No. 11, 1663-1667,-0001,():
-1年11月30日
Diastereoselective a-amidoalkylation of N,O-acetal, derivated from controlled regio and diastereoselective reduction of (S)-N-(4-methoxybenzyl)-3-silyloxyglutarimide provided two diastereomeric 6-allyl-5-silyloxy-2-piperidinones in 76:24 selectivity. The transformation of the major diastereomer into a known advanced intermediate allowed the synthesis of (+)-febrifugine and (+)-isofebrifugine.
piperidines,, alkaloids,, allylations,, N,, O-acetal,, asymmetric synthesis
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黄培强 , Pei-Qiang Huang, * Liang-Xian Liu, Bang-Guo Wei, and Yuan-Ping Ruan
Org. Lett., Vol. 5, No. 11, 2003,-0001,():
-1年11月30日
Selective and potent neurokinin substance P receptor antagonists (+)-L-733, 060 (1) and (+)-CP-99, 994 (2) have been synthesized starting from a new (3S)-piperidinol synthon derived from L-glutamic acid. The methods featured a C-2 regioselective reduction of glutarimide (9), Lewis acid-promoted Si to C-2 phenyl group migration of 10, and stereoselective reduction of acetylated oxime 19 as the key steps.
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