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贺林
多基因遗传病（精神疾病为主）、单基因遗传病、药物基因组学、生物信息学以及遗传资源保护等
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- 姓名：贺林
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- 担任导师情况：
- 学位：
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学术头衔：
博士生导师， “973”、“863”首席科学家 中国科学院院士，
- 职称：-
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学科领域：
光学
- 研究兴趣：多基因遗传病（精神疾病为主）、单基因遗传病、药物基因组学、生物信息学以及遗传资源保护等
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458
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成果数
10
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2005-03-04
【期刊论文】A case control and family based association study of the neuregulin1 gene and schizophrenia
贺林， X Zhao， Y Shi， J Tang， R Tang， L Yu， N Gu， G Feng， S Zhu， H Liu， Y Xing， S Zhao， H Sang， Y Guan， D St Clair， L He
J Med Genet 2004; 41: 31-34，-0001，（）：
-1年11月30日
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2005-03-04
贺林， M S Yang， L Yu， T W Guo， S M Zhu， H J Liu， Y Y Shi， N-F Gu， G Y Feng， L He
J Med Genet 2004; 000: 1-6.，-0001，（）：
-1年11月30日
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2005-03-04
贺林， JX Tang， ， WY Chen， G He， J Zhou， NF Gu， GY， Feng and L He
Molecular Psychiatry (2003) 0, 000-000.，-0001，（）：
-1年11月30日
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2005-03-04
贺林， ZHAO Jian*， ZHANG Zhizhou*， SHI Yongyong， Li Xiuxia & HE Lin
Chinese Science Bulletin 2004 Vol. 49 No.117-22，-0001，（）：
-1年11月30日
The postgenomic era has seen an emergence of new applications of DNA manipulation technologies, including DNA-based molecular computing. Surface DNA computing has already been reported in a number of studies that, however, all employ different mechanisms other than automaton functions. Here we describe a programmable DNA surface-computing device as a Turing machine-like finite automaton. The laboratory automaton is primarily composed of DNA (inputs, output-detectors, transition molecules as software), DNA manipulating enzymes and buffer system that solve artificial computational problems autonomously. When fluoresceins were labeled in the 5 end of (−) strand of the input molecule, direct observation of all reaction intermediates along the time scale was made so that the dynamic process of DNA computing could be conveniently visualized. The features of this study are: (i) achievement of finite automaton functions by linearly programmed DNA computer operated on magnetic particle surface and (ii) direct detection of all DNA computing intermediates by capillary electrophoresis. Since DNA computing has the massive parallelism and feasibility for automation, this achievement sets a basis for large-scale implications of DNA computing for functional genomics in the near future.
DNA,， computing,， automaton,， surface,， parallelism,， programmable.，
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2005-03-04
贺林， Qing-he Xing， ， * Ming-tai Wang， * Xiang-dong Chen， Guo-yin Feng， Hong-yun Ji， Jian-dong Yang， Jian-jun Gao， Wei Qin， Xue-qing Qian， Sheng-nan Wu， and Lin He
Am. J. Hum. Genet. 73: 000-000, 2003，-0001，（）：
-1年11月30日
Dyschromatosis symmetrica hereditaria (DSH) is a hereditary skin disease characterized by the presence of hyperpigmented and hypopigmented macules on extremities and face. The gene, or even its chromosomal location, for DSH has not yet been identified. In this study, two Chinese families with DSH were identified and subjected to a genomewide screen for linkage analysis. Two-point linkage analysis for pedigree A (maximum LOD score [Zmax]p 7.28 at recombination fraction [v] p 0.00) and pedigree B (Zmax p 2.41 at v p 0.00) mapped the locus for DSH in the two families to chromosome 6q. Subsequent multipoint analysis of the two families also provided additional support for the DSH gene being located within the region 6q24.2-q25.2, with Zmax p 10.64. Haplotype analysis confined the locus within an interval of 10.2Mbp, flanked by markers D6S1703 and D6S1708. The two families had no identical haplotype within the defined region, which suggests that the two families were different in origin. Further work on identification of the gene for DSH will open new avenues to exploration of the genetics of pigmentation.
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2005-03-04
【期刊论文】Family-based association study of DTNBP1 in 6p22.3 and schizophrenia
贺林， JX Tang， ， J Zhou， JB Fan， XWLi， YY Shi， NF Gu， GY Feng， YL Xing， JG Shi and L He
Molecular Psychiatry (2002) 0, 1-2.，-0001，（）：
-1年11月30日
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2005-03-04
贺林， JB Fan， ， WY Chen， JX Tang， S Li， NF Gu， GY Feng， G Breen， D St Clair and L He
Molecular Psychiatry (2002) 7, 446-447，-0001，（）：
-1年11月30日
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2005-03-04
【期刊论文】A family-based and case-control association study of the NOTCH4 gene and schizophrenia
贺林， JB Fan， ， JX Tang， NF Gu， GY Feng， FG Zou， YL Xing， JG Shi， SM Zhao， SM Zhu， LP Ji， WW Sun， YL Zheng， WQ Liu， G Breen， D St Clair， L He
Molecular Psychiatry (2002) 7, 100-103.，-0001，（）：
-1年11月30日
Recently a strong positive association between schizophrenia and Notch4 has been reported.1 Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as 300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations.
schizophrenia， Han， Chinese， family trios， Notch4， haplotype， TDT
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2005-03-04
【期刊论文】Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1
贺林， Bo Gao， ， Jingzhi Guo， Chaowen She， Anli Shu， Maosheng Yang， Zheng Tan， Xinping Yang， Shengzhen Guo， Guoying Feng， & Lin He
，-0001，（）：
-1年11月30日
Brachydactyly type A-1 (BDA-1; MIM 112500) is characterized by shortening or missing of the middle phalanges (Fig. 1a)1. It was first identified by Farabee in 1903 (ref. 2), is the first recorded example of a human anomaly with Mendelian autosomal- dominant inheritance and, as such, is cited in most genetic and biological textbooks. Here we show that mutations in IHH, which encodes Indian hedgehog, cause BDA-1. We have identified three heterozygous missense mutations in the region encoding the amino-terminal signaling domain in all affected members of three large, unrelated families. The three mutant amino acids, which are conserved across all vertebrates and invertebrates studied so far, are predicted to be adjacent on the surface of IHH.
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2005-03-04
【期刊论文】A Locus for Brachydactyly Type A-1 Maps to Chromosome 2q35-q36
贺林， Xinping Yang， Chaowen She， Jingzhi Guo， Albert CH Yu， ， Yingjin Lu， XiaoLiu Shi， Guoying Feng， and Lin He
Am. J. Hum. Genet. 66: 000-000, 2000，-0001，（）：
-1年11月30日
Brachydactyly type A-1 (BDA1) was, in 1903, the first recorded example of a human anomaly with Mendelian autosomal dominant inheritance. Two large families, the affected members of which were radiographed, were recruited in the study we describe here. Two-point linkage analysis for pedigree 1 (maximum LOD score [Zmax] 6.59 at recombination fraction [θ] 0.00) and for pedigree 2 (at) mapped the Z=5.53 v=0.00 locus for BDA1 max in the two families to chromosome 2q. Haplotype analysis of pedigree 1 confined the locus for family 1 within an interval of <8.1cM flanked by markers D2S2248 and D2S360, which was mapped to chromosome 2q35-q36 on the cytogenetic map. Haplotype analysis of pedigree 2 confined the locus for family 2 within an interval of <28.8cM flanked by markers GATA30E06 and D2S427, which was localized to chromosome 2q35-q37. The two families had no identical haplotype within the defined region, which suggests that the two families were not related.
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