陈峥嵘
骨科专业
个性化签名
- 姓名:陈峥嵘
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学术头衔:
博士生导师
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学科领域:
外科学
- 研究兴趣:骨科专业
著名骨科专家,现任复旦大学附属中山医院骨科主任医师、教授、博士生导师、复旦大学骨关节肿瘤中心主任、复旦大学关节镜培训中心主任,曾任复旦大学中山医院骨科主任。兼任中华医学会创伤学会副主任委员,上海市医学会创伤专科委员会主任委员,上海市医学会外科、骨科、手外科学会委员,上海市康复医学会修复重建外科专业委员会委员,国际矫形外科学会会员(SICOT),国际脊柱微创学会会员。《中华创伤杂志》副总编辑,《国外医学-骨科分册》编委,《中国法医学》等杂志编委。参加《实用外科学》、《临床外科学》、《脊柱创伤外科学》、《实用骨科手册》、《现代骨科学》等十余本医学专著的编写,担任大型专著《周围神经损伤基础与临床研究》、《内窥镜学》《外科手术并发症的预防与处理》的副主编。2002年主译出版了50余万字的专著《O’connor关节镜外科学》。陈峥嵘教授从事骨科专业近三十年,在国内外核心杂志发表论文60余篇,其中SCI论文10篇,培养硕士生博士生30余名,博士后1名。1994年获德国DAAD奖学金资助赴德国慕尼黑理工大学医学中心作访问学者。回国后致力于显微外科在骨科中的应用,在游离带血管腓骨修复治疗四肢骨关节肿瘤的临床工作中取得了较好的成绩。
1992年率先在国内开展经皮穿刺椎间盘关节镜下治疗腰椎间盘突出症,并与上海市科教电影制片厂联合摄制了该项专题的科教片,多次赴全国各地作示范手术,极大地推动了全国微创外科在脊柱外科中的应用。自80年代起他在陈中伟院士的带领下,从事周围神经损伤修复的基础研究,作为第二完成人参与了三项国家自然科学基金,三项国家教委博士点基金,一项卫生部重点实验室基金资助的工作。90年代以后他还积极从事组织工程软骨的构建、组织工程神经构建的研究,获得两项卫生部科研基金,一项上海市科委重点项目研究基金,一项国家自然科学基金的资助,并荣获上海市科技进步奖二等奖一项,上海市科技进步三等奖三项、上海卫生局科技进步二等奖一项。1996年他协助陈中伟院士完成了世界首例前臂再造手指控制的多自由度电子假手的研制,并获国家发明奖一等奖。
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成果数
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【期刊论文】雪旺细胞种于医用组织引导再生胶原膜构建自体人工神经的实验研究
陈峥嵘, 程飚
中华手外科杂志,2001,17(3):176-178,-0001,():
-1年11月30日
目的 设计并构建一种新型的神经引导导管。方法 将兔雪旺细胞种到用成粘蛋白多孔医用组织引导的再生胶原膜支架培养2周后,用倒置显微镜、扫描电镜观察雪旺细胞吸附、生长迁移情况;以雪旺细胞胶原膜管的形式植入体内,观察它诱导神经再生的能力。结果 成年兔雪旺细胞在医用组织引导再生胶原膜上生长良好,并均匀分布于支架表面,且基质分泌旺盛。体内模型发现神经已通过移植物长入远端,胶原膜已吸收。结论 雪旺细胞可以在多聚医用组织引导再生胶原膜上得到扩增,种有雪旺细胞的医用组织引导再生胶原膜导管可以形成一个诱导神经轴突再生的微环境,形成的三维立体结构具有人工神经的基本特性,为组织工程方法修复长段神经缺损提供了研究基础。
许旺氏细胞, 细胞培养, 组织工程, 神经,, 人工
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陈峥嵘, 陈中伟, 张峰, 程刚
中华创伤杂志,1994,10(4):152-154,-0001,():
-1年11月30日
利用桥接物修复1.0cm以上神经缺损,效果不理想。本实验采用自体静脉桥接家兔4.0cm长胫神经缺损,术后2个月未发生神经再生现象。而利用自体静脉内种植雪旺氏细胞匀浆,桥接家兔4.0cm长胫神经缺损,术后电生理、组织学、透射电镜等项检测指标都能观察到神经再生现象。雪旺氏细胞匀浆在静脉桥接物的这一作用,增加了非神经移植物修复神经缺损的长度。
周围神经缺损, 雪旺氏细胞
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陈峥嵘, WANG Yichao, CHEN Zhengrong, CHEN Zhongwei, GUAN Xiaoqun, SONG Houyan, WU Xin and LIU Yinkun
Chinese Medical Journal 2002; 115(9): 1352-1357,-0001,():
-1年11月30日
observed it s activity in stimulating neurite outgrowth in vitro. Methods cDNA encoding mature human HBNF was amplified from total RNA isolated from an 182week aborted human fetal brain by RT-PCR method. After amplification, the HBNF cDNA gene was cloned into p PIC9K, a shuttle expression vector for yea stsystem. The positive clone of expression vector bearing HBNF cDNA gene was obtained by screening. Verified recombinant vector was then used to transform Pichiastrain GS115 by electroporation. His+ transformants were selected on minimal dextrose medium (MD) plates which were histidine free1 His+ yeast recombinants with multi-copy insert s were screened in vivo by their resistance to G4181 PCR analysis was used to confirm the integration of the HBNF cDNA gene into the Pichia genome1 Secreted expre ssion of hrHBNF protein in culture medium was obtained when the positive clone containing the HBNF cDNA gene was induced by methanol. The hrHBNF product purified by gel chromatography was added to cultured rat pheochromocytoma (PC12) cells to observe it s ability to stimulate neurite outgrowth. Results In the recombinant expression vector, the insert was sequenced to show exactly the sequence encoding human HBNF according to Genbank data. The HBNF cDNA gene was cloned downstream to the α-factor, and it s open reading frame was in frame with the α-factor signal sequence in p PIC9K1 SDS2PAGE showed that the molecular weight of the induced expression product was about 18kDa, consistent with that of human HBNF reported in the literature. The protein product did promote neurite outgrowth in cultured rat pheochromocytoma (PC12) cells. Conclusion Recombinant human heparin-binding neurite-promoting factor can be expressed with a yeast system, and it s product possesses the biological activity to promote neurite outgrowth.
gene expression, recombinant proteins, Pichia pastoris, tumor cells,, cultured
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陈峥嵘, 陈中伟, 张光健
中华显微外科杂志,1996,19(3):161-163,-0001,():
-1年11月30日
目的:比较游离腓骨或吻合血管腓骨移植治疗切除四肢侵袭性骨肿瘤或恶性骨肿瘤后引起的长段骨缺损的临床疗效。方法:对18例吻合血管移植及4例游离腓骨移植术的病例术后,采用ECT、彩色多普勒血管超声检查、X线照片检查及随访,时间为术后2~12年,移植骨最长达26cm。结果:侵袭性骨肿瘤和恶性骨肿瘤18例,肿瘤切除后用吻合血管腓骨移植重建缺损,15例桡骨远端骨巨细胞瘤患者作游离腓骨移植重建缺损,结果前者愈合良好,移植骨片与受骨接合牢固,游离腓骨移植则愈合较差。结论:吻合血管腓骨移植可一期重建因骨肿瘤或骨恶性肿瘤广泛切除后造成的6cm以上的骨缺损,其优越性远远超过游离腓骨移植。
腓骨, 移植, 恶性骨肿瘤
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陈峥嵘, 张光健, 孙静娟
中华手外科杂志,1994,10(4):214-216,-0001,():
-1年11月30日
应用带血管腓骨治疗上肢侵袭性良性骨肿瘤和恶性骨肿瘤10例,不带血管腓骨治疗桡骨远端骨巨细胞瘤13例,总共23例。随访时间2~12年,随访中使用ECT(单光子照射扫描照相),彩色多普勒血管超声检查,以及X线片检查。结果显示带血管腓骨10例移植骨片生长良好,移植骨片与受骨愈合牢固;不带血管腓骨移植骨片长度超过6cm时愈合困难。本组带血管腓骨移植骨片最长26cm,最短9cm,这种手术最大的进步是病变组织可彻底切除,切除后可一期重建缺损组织。另一个优点是移植后的骨片周径可有增粗。
腓骨移植, 上肢, 骨肿瘤
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陈峥嵘, 陈中伟, 胡天培
,-0001,():
-1年11月30日
目的 将二足趾移植于前臂残端再造手指,利用再造手指控制多自由度电子假手治疗前臂部分缺失。方法 患者女性,19岁,右手及腕部在工作中不慎被机器碾碎,于腕上8cm行前臂截肢。取患者左足第二趾移植于前臂残端再造手指。移植术后二月,患者转入康复中心接受进一步康复训练。包括:①调整承重训练;②重量敏感性测试与训练;③手的稳定度测试与训练;④再造手指的控制能力测试与训练。结果 移植足趾存活良好。经过康复训练再造手指功能良好。指令控制测试中电子假手的准确度为100%。再造手指不仅能够准确地控制单自由度电子假手完成手指伸屈,而且能够精确地操纵三自由度电子假手完成假手手指的屈伸,以及腕关节的屈曲、背伸、旋前、旋后,有助于自理日常生活。结论 通过移植足趾于前臂残端,可以使电子假手达到100%的准确度。作者的报告为提高多自由度电子假手的控制准确度减少误动作提供了有用的途径和范例。
再造手指, 电子假手, 再造手指控制的电子假手
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【期刊论文】Progress of peripheral nerve repair
陈峥嵘, CHEN Zhengrong
Chinese Journal of Traumatology (English Edition) 2002; 5(6): 323-325,-0001,():
-1年11月30日
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【期刊论文】NERVE DEFECT REPARATION BY VEIN BRIDGING WITH SCHWANN CELL IMPLANTATION
陈峥嵘, CHEN Zheng-rong, CHEN Zhong-wei, ZHANG Feng, CHENG Gang
Chin J Traumatol, August 1997, Vol. 13, No.4,-0001,():
-1年11月30日
It was un satisfactory to use bridging material to repair nerve defect longer than 1.0cm. This experiment used autogenous vein to bridge rabbit tibia nerve with 4.0cm defect. The nerve regeneration did not occur two months after the operation. But when using autogenous vein bridging implanted with Schwann cell homogenate, the electrophysiology, histology, transmission electron microscopy, etc. indicated that the nerve regeneration did occur. This result showed that the length of reparation of nerve defect using non-nerve graft might be increased.
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陈峥嵘, Chen Zhengrong, Chen Zhongwei, and Zhang Guangjian
Chinese Medical Journal 1997; 110(2): 125-128.,-0001,():
-1年11月30日
Objective To compare the effect of vascularized and non-vascularized fibula grafting performed for the reconstruction of bone defects after the resection of bone tumors. Methods Vascularized fibula grafting was performed in 18 patients with malignant or aggressive benign bone tumor of the extremities. Non-vascularized fibula grafting was performed in 15 patients with giant cell tumor of the radius. All the 18 patients were followed up with radiography, single photon emission computed tomography (SPECT), colored Doppler's sonography (CDS) examinations and functional observation for 2 to 14 years. Results Vascularized fibula grafts with bone defects of 9 to 26cm showed good blood supply in emission computerized tomography (ECT) and radiography examinations, and bone union was achieved (Table 1). In non-vascularized fibula grafting cases (Table 2), bone union was not achieved. Cconclusions The advantages of vascularized grafting are the feasibility of one-stage reconstruction of various tissues and the growth of grafted fibula. It is necessary to adopt vascularized fibula grafting to reconstruct large bone defect resulting from the resection of extensive bone tumors, such as giant cell tumor (GCT), fibrous dysplasia of bone and malignant bone tumors.
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【期刊论文】Electronic artificial hand controlled by reconstructed digit
陈峥嵘, CHEN Zhongwei, CHEN Zhengrong and HU Tianpei
Chinese Journal of Traumatology (English Edition) 2000; 3(1): 326,-0001,():
-1年11月30日
Objective: To treat the loss of part of the forearm with a multi-dimension-freedom electronic artificial hand, which is controlled by a reconstructed finger transplanted from the second toe to the forearm stump. Methods: The female patient was 19 years old, whose right hand and wrist were crushed into pieces by machine at work and her forearm was amputated at the level of 8cm proximal to the wrist. The second toe of her left foot was transplanted to reconstruct the digit onto the stump of her forearm. Two months after the transplantation, the patient was transferred to the rehabilitation center for further rehabilitation training, which consisted of: training for adaptation to weight bearing, testing and training of sensibility to weight. testing and training for stability of the hand, and testing and training for the controlling function of the reconstructed digit. Results: The transplanted toe survived well. After rehabilitation the reconstructed digit functioned well. In testing the performance under control mandate, the accuracy rate of the electronic artificial hand was 100%. Conclusions: A 100% accuracy rate of the electronic artificial hand can be achieved by transplantation of the toe onto the stump of the forearm. It provides a useful pathway and an example for improvement of control accuracy of a multiple-freedom electronic artificial hand and reduction of false action.
Electronics, Hand injuries, Transplantation
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