陈湧
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- 姓名:陈湧
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无机化学
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陈湧,1972年7月出生于天津,1991年1995年在南开大学化学系学习,获理学学士学位;1995年—1998年于南开大学化学系攻读研究生,获理学硕士学位;19982001年在南开大学化学系攻读博士研究生,获理学博士学位。2001年进入中国科学院化学研究所工程塑料国家重点实验室任助理研究员,2002年受法国国家科研中心邀请赴法国Ecole Normale Supérieure大学从事博士后研究,2003年进入南开大学化学系任副教授。长期从事物理化学、有机化学和超分子化学研究,留学期间专门进行了含功能基的环糊精衍生物的合成和物理化学性质研究,具有丰富的有机合成与谱学研究的经验。在化学修饰环糊精的分子识别与分子组装和主—客体包结配位作用的热力学性质等方面的研究已有50余篇论文在国内外核心刊物上发表,其中有多篇发表在Acc. Chem. Res.、J. Am. Chem. Soc.、Chem. Eur. J.、J. Org. Chem、Org. Lett.、Chem. Commun.、Tetrahedron、Tetrahedron Lett.、Eur. J. Org. Chem.、Org. Biomol. Chem.等一流学术期刊上。2002年获教育部提名国家科学技术奖自然科学二等奖(第3完成人),2005年获天津市自然科学一等奖(第3完成人)。
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10
陈湧, YU LIU AND YONG CHEN
VOL. 39, NO. 10, 2006 / ACCOUNTS OF CHEMICAL RESEARCH,-0001,():
-1年11月30日
Possessing two β-cyclodextrin cavities in close vicinity and a functional linker with good structural variety in a single molecule, bridged bis(β-cyclodextrin)s can significantly enhance the original binding ability and molecular selectivity of native β-cyclodextrin and thus be successfully utilized in drug carriers, solubilizers, catalysis, photochemical materials, etc. This Account describes recent developments in the intramolecular cooperative binding and multiple recognition of bridged bis(β-cyclodextrin)s with functional linkers in solution, as well as their molecular assembly behaviors through the intermolecular cooperative binding. It also gives a description of unique properties and wide applications of bis(β-cyclodextrin)s and their assemblies.
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陈湧, Yong Chen, Kun-Ying Han and Yu Liu
Bioorganic & Medicinal Chemistry 15 (2007) 4537–4542,-0001,():
-1年11月30日
A water-soluble 8-aminoquinolino-b-cyclodextrin/1-adamantaneacetic acid (1/ADA) system is prepared in situ and exhibits a unique switch-on fluorescence response to Zn2+ over other common metal ions. Spectrophotometric studies demonstrate that this system can strongly coordinate Zn2+ through a cyclodextrin/substrate/metal triple recognition mode, and the resulting 1/ADA/Zn2+ ternary complex emits the blue-green fluorescence (λ= 490 nm) that can be easily distinguished by eyes in aqueous solution. Significantly, the switch-on fluorescence response of 1/ADA to Zn2+ is barely affected by various metal ions except Cu2+. As a result, this system can behave as an efficient supramolecular fluorescence sensor for Zn2+ in water.
Zinc, Fluorescence sensing, Cyclodextrin, 8-Aminoquinoline
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陈湧, Yu Liu, Yong Chen, Bin Li, Takehiko Wada, Yoshihisa Inoue
Chem. Eur. J. 2001, 7, No. 12,-0001,():
-1年11月30日
,6'-bis(β-cyclodextrin) s linked by 2,2'-bipyridine-4,4'-dicarboxy tethers; that is, 2,2'-bipyridine-4,4'-dicarboxy-bridged bis(6-O-β-cyclodextrin) (2) and N,N'-bis(2-aminoethyl)-2,2'-bipyridine-4,4'-dicarboxamide-bridged (3), N,N'-bis(5-amino-3-azapentyl)-2,2'-bipyridine-4,4'-dicarboxamide-bridged (4) and N,N'-bis(8-amino-3,6-diazaoctyl)-2,2'-bipyridine-4,4'-dicarboxamide-bridged bis(6-amino-β-deoxy-b-cyclodextrin) (5), has been synthesized as cooperative multipoint-recognition receptor models. The inclusion complexation behavior of 2-5 with organic dyes; that is, ammonium 8-anilino-1-naphthalenesulfonate, Brilliant Green, Methyl Orange, Acridine Red, and Rhodamine B, has been investigated in aqueous phosphate buffer solutions (pH 7.20) at 25 ℃ by means of ultraviolet, fluorescence, and circular dichroism spectrometry as well as by fluorescence lifetime measurements. The spectral titrations gave the complex stability constants (KS) and Gibbs’ free energy changes (△G°) for the inclusion complexation of 2-5 with the organic dyes and other thermodynamic parameters (△H°and △S°) for the inclusion complexation of 2-4 with the fluorescent dyes Acridine Red and Rhodamine B. Bis(β-cyclodextrin)s 2-5 displayed higher binding abilities toward most of the examined dye molecules than native β-cyclodextrin 1; this is discussed from the viewpoints of the size/shape-fit concept, the induced-fit interaction, and cooperative, multipoint recognition by the bridging chain and the dual hydrophobic cavities. Thermodynamically, the inclusion complexation of 2-4 with Acridine Red is totally enthalpy driven with a negative or minor positive entropic contribution, but the inclusion complexation with Rhodamine B is mainly entropy-driven with a mostly positive, but occasionally negative, enthalpic contribution; in some cases this determines the complex stability.
cyclodextrins, dyes/, pigments, molecular recognition, supramolecular chemistry, thermodynamics
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【期刊论文】noparticles and L-Try-CD Polypseudorotaxanes as Captors for Fullerenes
陈湧, Yu Liu, Hao Wang, Yong Chen, Chen-Feng Ke, and Min Liu
American Chemical Society J. AM. CHEM. SOC. 2005, 127, 657-666,-0001,():
-1年11月30日
A series of cyclodextrin-based polypseudorotaxanes (PPRs) were constructed by threading native β-cyclodextrin or L-tryptophan-modified β-cyclodextrin onto the amino-terminated PPG chains of different lengths. Subsequently, these PPRs were further assembled to form netlike supramolecular aggregates through the linkage of gold nanoparticles, and the resulting water-soluble Au-PPR aggregates were comprehensively characterized by FT-IR, UV, NMR, fluorescence spectroscopy, powder X-ray diffraction patterning, TG-DTA, and transmission electron microscopy. The results showed that the size and sedimentation rate of the Au-PPR aggregates were mainly dependent on the lengths of the PPG chains. Significantly, the Au-PPR aggregate 8, involving many L-tryptophan residues, showed not only a satisfactory water solubility but also a good capturing ability for fullerenes in aqueous solution. The 8-fullerene conjugate thus formed exhibited a good DNA cleavage ability under light irradiation.
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陈湧, Yu Liu, Yong Chen, Li Li, Gang Huang, Chang-Cheng You, Heng-Yi Zhang, Takehiko Wada and Yoshihisa Inoue
J. Org. Chem. 2001, 66, 7209-7215,-0001,():
-1年11月30日
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陈湧, Yu Liu, Yong Chen, Li Li, Heng-Yi Zhang, Shuang-Xi Liu, and Xu-Dong Guan
J. Org. Chem. 2001, 66, 8518-8527,-0001,():
-1年11月30日
To investigate quantitatively the cooperative binding ability of several β-cyclodextrin oligomers bearing single or multiligated metal center(s), the inclusion complexation behavior of four bis(β-cyclodextrin)s (2-5) linked by 2,2’-bipyridine-4,4’-dicarboxy tethers and their copper(II) complexes (6-9) with representative dye guests, i.e., methyl orange (MO), acridine red (AR), rhodamine B (RhB), ammonium 8-anilino-1-naphthalenesulfonic acid (ANS), and sodium 6-(p-toludino)-2-naphthalenesulfonate (TNS), have been examined in aqueous solution at 25 °C by means of UVvis, circular dichroism, fluorescence, and 2D NMR spectroscopy. The results obtained indicate that bis(β-cyclodextrin)s 2-5 can associate with one or three copper(II) ion(s) producing 2:1 or 2:3 bis-(β-cyclodextrin)-copper(II) complexes. These metal-ligated oligo(β-cyclodextrin)s can bind two model substrates to form intramolecular 2:2 host-guest inclusion complexes and thus significantly enhance the original binding abilities of parent β-cyclodextrin and bis(β-cyclodextrin) toward model substrates through the cooperative binding of two guest molecules by four tethered cyclodextrin moieties, as well as the additional binding effect supplied by ligated metal center(s). Host 6 showed the highest enhancement of the stability constant, up to 38.3 times for ANS as compared with parent β-cyclodextrin. The molecular binding mode and stability constant of substrates by bridged bisand oligo(β-cyclodextrin)s 2-9 are discussed from the viewpoint of the size/shape-fit interaction and molecular multiple recognition between host and guest.
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陈湧, Hao Wang, Yong Chen, Xiao-Yun Li, and Yu Liu
VOL. 4, NO. 2, 189-198 MOLECULAR PHARMACEUTICS 189,-0001,():
-1年11月30日
A novel oligo(ethylenediamino)-β-cyclodextrin-modified gold nanoparticle (OEA-CDNP) was synthesized as a vector for DNA binding and Comprehensively investigated by means of absorption and circular dichroism spectroscopies as well as transmission electron microscopy, and its plasmid transfection efficiency as a carrier into cultivated cells in vitro was also evaluated. Possessing many hydrophobic cavities at the outer space, OEA-CD-NP may have a capability of carrying biological and/or medicinal substrates into cells, which will make it potentially applicable in many fields of material science and biological technology. In contrast with OEACD-NP, the oligo(ethylenediamino)-lipoic amido-modified gold nanoparticle (OEA-L-NP) without CD was synthesized to investigate the interaction with DNA. The results showed that OEA-LNPs could only weakly bind DNA.
Nanoparticles, cyclodextrin, DNA, gene transfection, cytotoxicity
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陈湧, Yu Liu, Yong Chen, Shuang-Xi Liu, Xu-Dong Guan, Takehiko Wada and Yoshihisa Inoue,
ORGANIC LETTERS 2001 Vol. 3, No. 11 1657-1660 ,-0001,():
-1年11月30日
Newly synthesized bis(β-cyclodextrin-6-yl) 2,2'-bipyridine-4,4'-dicarboxylate was found to induce an unusual fluorescence enhancement of Rhodamine B (RhB) upon complexation. This effect is attributable to the equilibium shift of RhB to the highly fluorescent carboxylate ion form, which is induced by the cooperative binding by two appropriately preorganized cyclodextrin units in the bis(β-cyclodextrin). This sandwich complexation behavior was investigated by means of the fluorescence and 2D NMR spectroscopy.
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【期刊论文】Multi[2]rotaxanes with Gold Nanoparticles as Centers
陈湧, Yan-Li Zhao, Yong Chen, Min Wang, and Yu Liu
ORGANIC LETTERS 2006 Vol. 8, No. 7 1267-1270 ,-0001,():
-1年11月30日
The multi [2]rotaxanes with gold nanoparticles as centers are constructed by introducing chromophoric
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陈湧, Yong Chen, Yali Wang, Andr
Tetrahedron 62 (2006) 2045–2049,-0001,():
-1年11月30日
Two b-cyclodextrin–C60 conjugates (3 and 4) with a flexible linker at the secondary face of cyclodextrin are synthesized by a single reaction of 2-(ω-azidoundecanyl)-2-O-heptakis (2,3,6-tri-O-methyl)-b-cyclodextrin (2) and C60, both of which display satisfactory water solubility. Structural analyses show that 3 is a closed [5,6] aziridinofullerene, whereas 4 is a bis-adduct derivative. Using rhodamine B (RhB) as a guest molecule, the inclusion complexation behavior of 3 was investigated in aqueous solution
Fullerene, C60, Cyclodextrin, Conjugate, Rhodamine B
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