滕皋军
医学影像及介入放射学
个性化签名
- 姓名:滕皋军
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学术头衔:
博士生导师
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学科领域:
核医学
- 研究兴趣:医学影像及介入放射学
滕皋军,1962年8月生,自1982年以来。一直从事医学影像及介入放射学工作,1995-1998年在美国Dartmouth-Hitchcock医学中心研修介入诊疗技术。在介入放射学临床及基础研究均有重大建树;2002年建立国内首家分子影像实验室并积极倡导和开展分子影像这一新兴学科的研究。多次应邀赴美国,日本和韩国作专题学术报告。 获中华医学科技奖二等奖和三等奖各1项,江苏省科技进步二等奖2项。目前担任的学术职务包括:中华放射学会介入放射学专业组付组长,和亚太心血管介入学会(APCCVIR)中国区委员,江苏省放射学会主任委员,《中华医学杂志》编委会委员,《中华放射学杂志》编委会委员及《中国介入影像与治疗学》编委会执行主编等。
在脊柱疾病的介入/微创治疗方面有重大贡献,尤其在治疗腰椎间盘突出症,经皮椎体成形术治疗椎体肿瘤和骨质疏松症所致的压缩性骨折方面有多项创新,包括发明了新型的椎间盘摘除器, 开展了前瞻新临床对照研究,治疗病例4000余例, 疗效达国际先进水平;在TIPS再狭窄形成机制研究方面有重大发现,创立了胆汁影响TIPS再狭窄形成的新理论。在肿瘤介入治疗等领域也有重要成就。在国内首先开创干细胞磁粒子标记与MR示踪等分子影像学研究, 为分子影像学在中国迅速发展作出突出贡献。承担主持国家自然科学基金3项,863项目1项,教育部博士点基金1项,其它省部级项目10余项。
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滕皋军, Gao-Jun Teng, MD Michael A. Bettmann, MD P. Jack Hoopes, DVM, PhD Robert J. Wagner, MA Byeong-Ho Park, MD Li Yang, MD, PhD Brian R. Baxter
Bile Leak In Transjugular intrahepatic Portosystemic Shunts Volume 208 Number 3,-0001,():
-1年11月30日
PURPOSE: To evaluate the effect of bile on smooth muscle cell (SMC) proliferation in vitro and in vivo in a porcine transjugular intrahepatic portosystemic shunt (TIPS) model. MATERIALS AND METHODS: In vitro, SMCs explanted from porcine thoracic aorta were cultured with standard techniques. After initial pilot studies, they were subcultured in one of three groups: 1% porcine serum plus 1% bile, 10% porcine serum plus 1% bile, and 10% porcine serum. Cells were harvested at 3, 10, or 14 days, and DNA, protein, and disintegrations per minute (an indicator of proliferation) were measured. In vivo, TIPS creation was successful in 45 swine. All pigs were euthanized at 10-16 days. The proliferative response within the stent was histologically quantified and correlated for evidence of bile leak. RESULTS: In pilot studies, 2.5%-10.0% bile solutions caused 100% SMC mortality by 3 days. In the presence of 1% bile (with or without porcine serum), both DNA and protein production decreased significantly compared with that in porcine serum alone (P<0.05). In vivo, 13 of 45 specimens (29%) showed bile leak at gross or microscopic examination. SMC proliferation was less overall in animals with versus those without bile leak (difference not significant). CONCLUSION: These data suggest that the proliferative response in a TIPS is not primarily due to bile leak. Bile leak may promote thrombosis, but it appears to inhibit myointimal proliferation.
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滕皋军, Gao-Jun Teng, Shi-Cheng He, Gang Deng, Jin-He Guo, Wen Fang, Guang-Yu Zhu
,-0001,():
-1年11月30日
The objective of this study was to simplify the opacifying mixing process of the bone cement and contrast used for percutaneous vertebroplasty (PVP). We performed a biomechanical study of polymethyl methacrylate (PMMA) (CorinplastTM 3) using three different mixtures of PMMA, monomer, and contrast: group Ⅰ, 2:1; group Ⅱ, 3:2; group Ⅲ, 3:2:1 ratio of powder/monomer/iodinated contrast (Omnipaque). In vitro biomechanical testing of ultimate compressive strength was carried out in all samples. Following the conclusion of a proper bone cement mixture regimen drawn from the in vitro study, PVP was performed in 125 patients: 58 with cancer, 12 with hemangioma, and 54 with osteoporotic fracture. The ultimate compressive strength in group Ⅲ was decreased by 38% compared to groups Ⅱ and Ⅰ. Proper fluoroscopic visualization was achieved in all PVP procedures using this mixture. There were no major complications associated with injection of the cement mixture. Complete (CR) and partial response (PR) was obtained in 64% and 32.8%, respectively. No further vertebral collapse occurred during follow-up. The regimen using iodinated contrast for cement visualization during PVP provides a simple and convenient new method for mixing. Although the biomechanical strength is altered by the contrast medium added, it seems insignificant in clinical practice based on the authors' limited experience.
Vertebroplasty,, percutaneous-Vertebral fracture,, osteoporosis-Vertebrae,, tumors-Bone cement,, opacifier
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滕皋军, Gao Jun Teng, Michael A. Bettmann, P. Jack Hoopes and Li Yang
,-0001,():
-1年11月30日
AIM To evaluate a new balloona2expandable stainless steel stent (Cordis stent) in a transjugular intrahepatic portosystemic shunt (TIPS) porcine model and compared with Wallstent.METHODS TIPS was performed in 26 normal domestic pigs weighing 20kg-30kg using a Cordis stent or Wallstent (13 pigs in each stent). All pigs were sacrificed at the 14th day after TIPS. The stent deployment delivery system, stent patency, and stent recoil after placement were evaluated.Proliferative response in representative histological sections from the center, hepatic and portal regions of the two stent designs were quantified.RESULTS The shunt was widely patent in 4 pigs in the Cordis stent group (4/12, premature dead in 1 pig), and in 5 pigs in the Wallstent group (5/13). All remaining stents of both designs were occluded or stenotic. The mean quantified proliferation including thickness of the proliferation and the ratio of proliferation: total area in three assayed regions in Cordis stent and Wallstent was 2.18mm2 2:00mm, and 59.18mm2. 51.66mm2, respectively (P<0.05). The delivery system and mechanical properties of the Cordis stent fuctioned well.CONCLUSION The new Cordis stent is appropriate for TIPS procedure.
hypertention/, portal, portosystemic shunt/, surgical, stents, radiology/, interventional, balloon dilatation, swine
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