蔡青云
1. 纳米生物传感技术;2. 无线传感技术研究;3. 纳米功能材料研究。
个性化签名
- 姓名:蔡青云
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
分析化学
- 研究兴趣:1. 纳米生物传感技术;2. 无线传感技术研究;3. 纳米功能材料研究。
蔡青云,教授,博士生导师,1986年于湖南大学化学系分析化学专业硕士毕业并留校,1996年获得湖南大学化学系分析化学专业博士学位并于同年晋升副教授,1997年9月赴韩国科学技术院(Korea Advanced Institute of Science and Technology)生物工程系从事博士后研究, 1998年7月转赴美国,先后在University of Michigan和University of Kentucky 继续博士后研究, 2002年元月回国,2003年受Pennsylvania State University 邀请进行为期一年的合作研究,现效力于湖南大学化学系,化学生物传感与计量学国家重点实验室。
主要研究领域:1. 纳米生物传感技术:采用纳米器件、纳米单晶、和纳米技术设计、构筑针对环境污染物或生命活体物质的纳米生物传感器及其阵列;2. 无线传感技术研究:基于磁致伸缩原理开发新型的无线传感测定技术;设计制作无线传感器;发展系列针对生命活体物质和食品污染物的,可用于临床、环境监测、和食品分析的无线传感测定技术;3. 纳米功能材料研究:合成、制备系列金属有机物、半导体金属氧化物纳米功能材料,发展纳米传感技术;开发具有高光电转换效率的带隙可调金属氧化物纳米功能材料和高催化效率的纳米功能材料,研究晶体掺杂技术和光催化机理;针对能源危机发展太阳能电池、光催化水裂解技术;针对化境污染发展具有高光催化活性的纳米功能材料用于环境有机污染物的光催化降解。
目前主持和参加的主要科研项目:1、无线活体在体传感分析技术研究(主持,国家自然科学基金,23万);2、细菌早期检测的无线磁传感原理与方法研究,(主持,国家自然科学基金, 28万);3、C/C复合材料热处理过程组织结构演变机制 (主研,科技部973,300万)。
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成果数
16
蔡青云, Pengfei Pang, Zongduan Guo, Qingyun Cai*
Talanta 65(2005)1343-1348,-0001,():
-1年11月30日
Two gold-thiolate monolayer-protected nanoparticles were synthesized and used as interfacial layers on chemiresistor sensors for the analysis of violate organic compounds (VOCs). Toluene, ethanol, acetone and ethyl acetate were chosen as the target vapors. Both the resistance and capacitance were measured as the function of analyte concentrations. The effect of humidity on the sensor sensitivity to VOCs was investigated. The sensitivity decreases with humidity increasing, depending on the hydrophobicity of the target compounds. Less effect was observed on the higher hydrophobic compounds. While the relative humidity (RH) increased from 0 to 60%, the sensitivity to acetone decreased by 39 and 37%, respectively on the Au-octanethiol (C8Au) and Au-2-phenylethanethiol (BC2Au) coated sensors, while the sensitivity to toluene decreased by 12 and 14%, respectively. These results show that the sensors coated with hydrophobic compounds protected-metal nanoparticles can be employed in high humidity for hydrophobic compounds analysis. The resistance responses to VOCs are rapid, reversible, and linear, while the capacitance response is not sensitive and consequently not applicable for VOCs analysis. The response mechanism was also discussed based on the sensor response to water vapor. The capacitance response is not sensitive to the film swelling in dry environment.
Nanoparticle, Chemiresistor, Sensor, Humidity, Vapor analysis
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【期刊论文】A Wireless, Remote Query Glucose Biosensor Based on a pH-Sensitive Polymer
蔡青云, Qingyun Cai, † Kefeng Zeng, † Chuanmin Ruan, † Tejal A. Desai, ‡ and Craig A. Grimes*, †
Anal. Chem. 2004, 76, 4038-4043,-0001,():
-1年11月30日
This paper describes a wireless, remote query glucose biosensor using a ribbonlike, mass-sensitive magnetoelastic sensor as the transducer. The glucose biosensor is fabricated by first coating the magnetoelastic sensor with a pH-sensitive polymer and upon it a layer of glucose oxidase (GOx). The pH-responsive polymer swells or shrinks, thereby changing mass, respectively, in response to increasing or decreasing pH values. The GOx-catalyzed oxidation of glucose produces gluconic acid, inducing the pH-responsive polymer to shrink, which in turn decreases the polymer mass. In response to a time-varying magnetic field, a magnetoelastic sensor mechanically vibrates at a characteristic resonance frequency, the value of which inversely depends on sensor mass loading. As the magnetoelastic films are magnetostrictive, the vibrations launch magnetic flux that can be remotely detected using a pickup coil. Hence, changes in the resonance frequency of a passive magnetoelastic transducer are detected on a remote query basis, without the use of physical connections to the sensors. The sensitivity of the glucose biosensors decreases with increasing ionic strength; at physiological salt concentrations, 0.6mmol/L of glucose can be measured. At glucose concentrations of 1-10mmol/L, the biosensor response is reversible and linear, with the detection limit of 0.6mmol/L corresponding to an error in resonance frequency determination of 20Hz. Since no physical connections between the sensor and the monitoring instrument are required, this sensor can potentially be applied to in vivo and in situ measurement of glucose concentrations.
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【期刊论文】Dual-Chemiresistor GC Detector Employing Monolayer-Protected Metal Nanocluster Interfaces
蔡青云, Qing-Yun Cai and Edward T. Zellers*
Anal. Chem. 2002, 74, 3533-3539,-0001,():
-1年11月30日
The synthesis and testing of two gold-thiolate monolayerprotected (nano)clusters as interfacial layers on a dualchemiresistor vapor sensor array are described. Responses (changes in dc resistance) to each of 11 organic solvent vapors are rapid, reversible, and linear with concentration at low vapor concentrations, becoming sublinear at higher concentrations. Limits of detection (LODs) range from 0.1 to 24 parts per million and vary inversely with solvent vapor pressure. When configured as a GC detector and used to analyze 0.5-L preconcentrated samples of the 11-vapor mixture, the array provides LODs of e700 parts per trillion for most vapors, comparing favorably with those from an integrated array of polymer-coated surface acoustic wave sensors configured and tested similarly. This first report on the use of such an array as a GC detector shows that the combination of response patterns and GC retention times improves capabilities for vapor recognition compared to the sensor array alone or to single-detector GC systems. Spray-coated nanocluster thin films can be deposited reproducibly and exhibit response stability in air that ranges from fair to excellent for up to several months. Scaling the active device area down by a factor of 16 has no significant effect on sensitivity. Implications of these results for portable vapor sensing systems are discussed.
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【期刊论文】A salt-independent pH sensor
蔡青云, Qing Y. Cai. Craig A. Grimes*
Sensors and Actuators B 79(2001)144-149,-0001,():
-1年11月30日
nd salt concentration The nH sensor is comprised of two lnalletoelastic thick fihn elements; one is costed with the uH and salt concentration sensitive mass chanzing Polylner poly(acrylic acid co isooctylacrylate)(pAA iOAl, while the other is costed with poly(3 snlfopropyl methacrylate co isooctylacrylate) (pSPMA-IOAl), a PelvelectrelVte gel the lllass of which is salt dependent but pH-independent The magnetoelastic elements mechanicallV vibrate at a resonant frequency‘inversel dependent 11Don the lllass nf the attached polymer laver Cross COlTelation between the frequency response 0fthetwo sensor elementsisusedto eliminatethe effectof salt concentration onthePHnleasmenlents. which arelinear between pH 5.4 and 7.2, with a slope nf 310Hz/pH (0.6%fr/pH).
pH sensor, Polymm swellialg, Salt effect, Polyelectrolvte gel, Wheless
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【期刊论文】A wireless micro-sensor for simultaneous measurement of pH, temperature, and pressure
蔡青云, Mahaveer K Jain, Qingyun Cai and Craig A Grimes
Smart Mater. Struct. 10(2001)347-353,-0001,():
-1年11月30日
In response to a magnetic field impulse, magnetostrictive magnetoelastic sensors mechanically vibrate. These vibrations can be detected in several ways: optically from the amplitude modulation of a reflected laser beam, acoustically using a microphone or hydrophone, and by using a pickup coil to detect the magnetic flux emitted from the sensor. Earlier work has shown that the resonant frequency of a magnetoelastic sensor shifts in response to different environmental parameters, including temperature, pressure, fluid flow velocity and mass loading, with each parameter determined in an otherwise constant environment. To extend the utility of the sensor technology in this work we report on the fabrication and application of a miniaturized array of four magnetoelastic sensors that enable the simultaneous remote query measurement of pH, temperature, and pressure from a passive, wireless platform.
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【期刊论文】A wireless, remote query ammonia sensor
蔡青云, Qing Y. Cai, Mahaveer K. Jain, Craig A. Grimes*
Sensors and Actuators B 77(2001)614-619,-0001,():
-1年11月30日
This paper presents a wireless, remote query 3111111Ollia sensor comprised of a free standing nlaglletoelastic tbick fihll coated with a polymer, poly(acrylic acid co isooctylacrylate), tbat changes mass in response to atmospheric annnonia concentration. The mass of the polymer layer modulates the resonant frequency the fen-omagnetic magnetoelastic substrate, hence by monitoring the frequency response of the sensor, atmospheric Nit3 concentralion can be determined remotely, witbout the need for physical comleclions to the sensor or specific alignment requirements. The effect of copolymer composition, polymer fihn thickness, and relative humidity level (RH) on the sensitivity of the sensor were investigated. The sensor linearly tracks ammonia concentration below 0.8vol.%, and tracks higber concentrations logmitbmically; witfiin the linem calibration range, a 0.02vol.% change in Nit3 concentration call be detected.
NH3 sensor, Polymer, Magnetoelastic, Magnetostfictive, Wheless
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【期刊论文】A wireless, remote query magnetoelastic CO2 sensor†
蔡青云, Qing Y. Cai, a, Arthur Cammers-Goodwin b and Craig A. Grimes*a
J. Environ. Monit., 2000, 2, 556-560,-0001,():
-1年11月30日
This paper presents a wireless, passive, remote query CO2 sensor comprising a ribbon-like magnetoelastic thick-flm coated with a mass-changing CO2 responsive polymer synthesized from acrylamide and isooctylacrylate. In response to a magnetic feld impulse, the magnetostrictive magnetoelastic sensor vibrates at a characteristic resonant frequency that is inversely dependent upon the mass of the attached CO2 responsive polymer. The mechanical vibrations of the magnetostrictive sensor launch magnetic fux, which can be detected remotely using a pickup coil. By monitoring the resonant frequency of the passive sensor, the atmospheric CO2 concentration can be determined without the need for physical connections to the sensor or specifc alignment requirements. The effect of humidity and the CO2 responsive copolymer composition on the measurement sensitivity are reported. Greatest sensitivity is achieved with a polymer comprising a 1:1 mole ratio of acrylamide to isooctyl acrylate. A 0.7% change in atmospheric CO2 concentration can be detected for a 20mm thick polymer coated sensor.
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【期刊论文】A remote query magnetoelastic pH sensor
蔡青云, Qing Y. Cai, Craig A. Grimes*
Sensors and Actuators B 71(2000)112-117,-0001,():
-1年11月30日
A remote query magnetoelastic pH sensor comprised of a magnetoelastic thick-flm coated with a mass-changing pH-responsive polymer is described. In response to a magnetic query feld the magnetoelastic sensor mechanically vibrates at a characteristic frequency that is inversely dependent upon the mass of the attached polymer layer. As the magnetoelastic sensor is magnetostrictive the mechanical vibrations of the sensor launch magneticux that can be detected remotely from the sensor using a pickup coil. The pH responsive copolymer is synthesized from 20mol% of acrylic acid and 80mol% of iso-octyl acrylate and then deposited onto a magnetoelastic flm by dip-coating. For a 1mm polymer coating upon a 30 mm thick Metglas [The Metglas alloys are a registered trademark of Honeywell Corporation. For product information see: http://www.electronicmaterials.com:80/businesses/sem/amorph/page5_1_2.htm.] alloy 2826MB magnetoelastic flm between pH 5 and 9 the change in resonant frequency is linear, approximately 285 Hz/pH or 0.6%/pH. The addition of 10mmol/l of KCl to the test solution decreases the sensitivity of the polymer approximately 4%.
pH sensor, Magnetoelastic, Magnetostrictive, Remote query
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【期刊论文】Vapor recognition with an integrated array of polymer-coated flexural plate wave sensors
蔡青云, Qing-Yun Cai a, Jeongim Park a, Dylan Heldsinger a, Meng-Da Hsieh a, Edward T. Zellers a, b, )
Sensors and Actuators B 62 2000. 121-130,-0001,():
-1年11月30日
Preliminary testing of a prototype instrument employing an integrated array of six polymer-coated flexural plate wave FPW.sensors and an adsorbent preconcentrator is described. Responses to thermally desorbed samples of individual organic solvent vapors and binary and ternary vapor mixtures are linear with concentration, and mixture responses are equivalent to the sums of the responses of the component vapors, which co-elute from the preconcentrator in most cases. Limits of detection as low as 0.3ppm are achieved from a 60-s 34cm3. air sample and peak widths at half-maximum range from 1 to 4s. Tests at different flow rates suggest that the kinetics of vapor sorption in the sensor coating films may limit responses at higher flow rates, however, low data acquisition rates may also be contributory. Assessments of array performance using independent test data and Monte Carlo simulations with pattern recognition indicate that individual vapors and certain binary and ternary mixtures can be recognizedrdiscriminated with very low error. More complex mixtures, and those containing homologous vapors, are problematic. This is the first report demonstrating multi-vapor analysis with an integrated FPW sensor array. q2000 Elsevier Science S.A. All rights reserved.
Vapor sensor, Sensor array, Acoustic-wave sensor, Pattern recognition, Vapor recognition, Flexural plate wave
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蔡青云, Edward T. Zellers a, b, *, Masako Morishita a, Qing-Yun Cai a
Sensors and Actuators B 67 2000. 244-253,-0001,():
-1年11月30日
Measuring environmental concentrations of organic vapors with microfabricated chemical sensors or sensor arrays often requires a means to enrich collected samples prior to detection. With such an application in mind, a preliminary evaluation is described of two porous-layer open tubular PLOT.capillary traps as vapor preconcentrators for a series of vapors. Short1-cm.sections of commercial PLOT-Q and PLOT-S capillary having wall coatings of styrene-divinylbenzene copolymer and vinylpyridine-divinylbenzene copolymer, respectively, are fitted with a metal sleeve for rapid thermal desorption of preconcentrated vapor samples, and tested using a downstream 97-MHz polyisobutylene-coated surface acoustic waveSAW.sensor. Calibrated responses to vapors of 2-butanoneMEK., trichloroeth-yleneTCE., toluene, and m-xylene are collected with and without preconcentration. Dimethylmethylphosphonate could not be efficiently desorbed from either PLOT trap. For the remaining vapors, increases in sensitivity of 3-9-fold are achieved by preconcentrating and analyzing just 1ml of sample air. Calculated limits of detection.range from 1-8 ppm. Differences in sensitivities are observed between the PLOT-Q and PLOT-S sampling trains for MEK and TCE. A theoretical model of penetration yields limiting values of flow rate and trap dimensions. Measured 10%-breakthrough times at 1 mlrmin ranged from; 1 to 6min and, for PLOT-Q, are G modeled values obtained using the modified Wheeler equation. The implications of the results for the design and operation of microanalytical systems for vapor analytes are discussed.
Microanalytical system, PLOT, Preconcentrator, Surface acoustic wave sensor, Vapor sensor
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