袁直
主要从事生物医用高分子材料以及吸附分离材料的设计及识别机制研究
个性化签名
- 姓名:袁直
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
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学科领域:
高分子化学
- 研究兴趣:主要从事生物医用高分子材料以及吸附分离材料的设计及识别机制研究
袁直,南开大学化学学院副院长。1989年获博士学位后留南开大学高分子所任讲师,1992年破格晋升为副研究员,1996年破格晋升为研究员。2000年7月,任南开大学化学院副院长,高分子所所长。 现任国家基金委材料学部评审委员,天津市重大科技攻关项目、产业化项目评审专家,中国生物医学工程学会生物材料分会理事,天津市生物医学工程学会理事,《高分子学报》编委,《离子交换与吸附》副主编。2000年入选教育部跨世纪优秀青年培养计划,天津市“131”工程第一层次培养计划。
主要从事生物医用高分子材料以及吸附分离材料的设计及识别机制研究。作为负责人,先后主持国家自然科学基金重点项目、“973”子课题、天津市科学基金重点项目、多项国家自然科学基金以及省部级科学基金。已在Biomaterial、Biomacromolecules等国内外重要刊物上发表SCI研究论文90余篇。曾获中国化学会青年化学奖,天津青年科技奖(个人奖),教育部科技进步三等奖,科技部杜邦科技创新奖,南开大学优秀教师一等奖,1999年全国先进女职工称号。
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成果数
12
袁直, Guohua Li, † Jihong Li, † Wei Wang, † MeiYang, † Yuanwei Zhang, † Pingchuan Sun, † Zhi Yuan, *, † Binglin He, † and Yaoting Yu‡
Biomacromolecules 2006, 7, 1811-1818,-0001,():
-1年11月30日
To remove uremic octapeptide from the blood stream of uremic patients, various modified polyacylamide crosslinked absorbents were prepared. Adsorption experiments showed these absorbents have significant differences in adsorption capacity to the target peptide. In this paper, two-dimension proton nuclear magnetic resonance (2D 1H NMR) spectroscopy was used to investigate the interaction mechanism between the peptide and the adsorbents. Because of the insolubility of the absorbent, some soluble linear polymers with the same functional groups as the absorbents were employed as the model adsorbents in 2D 1H NMR. The preferred binding site for the peptide and polymers was identified to be at the C-terminal carboxyl group of the octapeptide via chemical shift perturbation effects. In this study, we found that hydrogen bonding, electrostatic, and hydrophobic interactions all play a role in the interaction force but had different contributions. Especially, the great chemical shift changes of the aromatic amino acid residues (Trp) during the interaction between butyl-modified polyacrylamide and octapeptide suggested the hydrophobic interaction, incorporated with the electrostatic force, played an important role in the binding reaction in aqueous solutions. This information not only rationally explained the results of the adsorption experiments, but also identified the effective binding site and mechanism, and shall provide a structural basis for designing better affinity-type adsorbents for the target peptide.
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【期刊论文】Synthesis and characterization of novel functionalized polylactides with pendent hydroxyl arms
袁直, Liang Wang, Xiaohua Jia, Zhi Yuan*
Polymer 47 (2006) 6978-6985,-0001,():
-1年11月30日
A class of polyesters have been synthesized by the ring-opening copolymerization of DL-lactide (DLLA) and RS-benzyloxyethyl-b-malolactonate (MABE) using different monomer feeding doses. The compositions and structures of poly(DL-lactide-co-RS-benzyloxyethyl-b-malolactonate) (poly(DLLA-co-MABE)) were determined by 1H and 13C NMR measurements. GPC measurement showed that the molecular weight of the copolymers decreased as the MABE content increases. After catalytic hydrogenation of the benzyl ether functions, the desired copolymers with pendent hydroxyl arms, poly(DL-lactide-co-RS-hydroxyethyl-b-malolactonate) (poly(DLLA-co-MAHE)), were recovered. Thermal properties of poly(DLLA-co-MABE) and poly(DLLA-co-MAHE) copolymers were examined by differential scanning calorimetry (DSC) measurement. Single glass transition temperature appeared in the DSC spectra, which confirmed that the copolymers were true copolymers and not blends. The hydrophilicity of poly(DLLA-co-MAHE) copolymer was tunable, which increased with the increase in MAHE content. Furthermore, the hydrolytic degradation of poly(DLLA-co-MAHE) material was investigated and the results showed that faster degradation was observed in the copolymer film containing more MAHE content.
DL-Lactide, RS-Benzyloxyethyl-b-malolactonate, Poly(, DL-lactide-co-RS-hydroxyethyl-b-malolactonate),
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【期刊论文】Studies on endotoxin removal mechanism of adsorbents with amino acid ligands
袁直, Zhong Wei a, Wei Huang a, Jihong Li a, Guanghui Hou a, Jie Fang b, Zhi Yuan a, ∗
Journal of Chromatography B, 852 (2007) 288-292,-0001,():
-1年11月30日
In this paper, a series of adsorbents with different amino acid ligands for endotoxin removal were prepared and endotoxin adsorption capacities (EAC) in aqueous solution were studied using an affinity column. The results showed that the property and structure of amino acid ligands have great influence on EAC. As the increasing of isoelectric point and polarity of amino acids ligands, EACs of the adsorbents increased. In addition, computer simulation method was employed to a further investigation on the interaction between endotoxins and ligands. Based on the results, some adsorbents were applied to remove endotoxin from endotoxemia rabbit’s serum. Similar adsorption results were observed and the removal efficiency of adsorbents with Arg, Ser ligands is up to 78%.
Endotoxin, Amino acids, Affinity adsorbents, Computer simulation
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袁直, Zhi YUAN, Tianjin (CN); Wei Huang, Tianjin (CN); Qin Tian, Tianjin (CN); Chuangnian Zhang, Tianjin (CN); Liang Hart, Tianjin (CN); Tong Liu, Tianjin (CN); Yue Zhang, Tianjin (CN); Yue Chen, Tianjin (CN)
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-1年11月30日
Disclosed are a hepatic targeted drug delivery system and a process for preparing the same. Also disclosed is a method for treating liver cancer.
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袁直
,-0001,():
-1年11月30日
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袁直
,-0001,():
-1年11月30日
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【期刊论文】Isolation and purification of uremic middle molecules by multi-step liquid chromatography
袁直
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-1年11月30日
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