宋芸
个性化签名
- 姓名:宋芸
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
- 职称:-
-
学科领域:
勘查地质学
- 研究兴趣:
宋芸,女,1974年8月生于山东费县,德国洪堡学者。现在天津大学药物科学与技术学院任讲师职务。
1998年9月至2001年3月,在天津大学化工学院陈立功教授指导下攻读硕士学位,对叶蜂性信息素合成路线进行了广泛地设计、研究和探讨,对控制叶蜂繁殖,保护油松做出了重要贡献。
2001年9月至2004年7月,在南开大学化学系刘育教授指导下攻读博士学位,主要从事超分子化学方面的研究工作。主要创新点是设计合成了荧光基团修饰的桥联双环糊精体系,可以识别非荧光的药物分子,研究工作极大丰富了超分子主体的研究内容,相关工作已发表在J. Org. Chem., 2003, 68, 3687. ( IF=3.675 )和Chem. Eur. J. 2004, 10, 3685. ( IF = 4.907 )上,并被国内外同行引用多次。此外,通过金属软连接构筑了双带聚轮烷和双分子纳米管道,对纳米组装技术具有重要的理论指导意义和潜在的应用价值,工作发表在Macromolecules, 2004, 37, 6370 ( IF= 4.024 )上。由于成绩突出,于2004年6月荣获香港求是基金会颁发的求是研究生奖学金。
2005年7月受国际著名的德国洪堡基金会资助,在德国亚琛工业大学从事博士后研究工作。独立完成了洪堡基金项目“磷功能化儿茶酚金属超分子聚集体”,相关工作已经发表在synthesis, 2006, 18, 3037 ( IF=2.401 )上。
2006年6月,被遴选参加了在德国林岛举行的第18届诺贝尔化学奖年会,和诺贝尔化学奖大师进行了零距离接触和交流。
2006年12月底回国后,作为项目负责人现正主持国家自然科学基金和教育部博士点基金各一项,并作为项目组的第一在研人参与多项课题的研究工作。
迄今共发表专业学术论文近20篇,影响因子3.0以上为6篇,被国内外同行引用100多次。
-
主页访问
4154
-
关注数
0
-
成果阅读
442
-
成果数
10
宋芸, Yu Liu, Yun Song, Hao Wang, Heng-Yi Zhang, Takehiko Wada, Yoshihisa Inoue
J. Org. Chem., Vol. 68, No. 9, 2003,-0001,():
-1年11月30日
A novel bis(β-cyclodextrin) was synthesized, and its binding behavior with steroids was investigated to demonstrate that the cooperative co-inclusion of guest and tether by two cyclodextrin moieties is operative to afford the highest molecular selectivity of up to 3.6 for deoxycholate over taurocholate.
-
34浏览
-
0点赞
-
0收藏
-
0分享
-
117下载
-
0评论
-
引用
宋芸, Yu Liu, Yun Song, Yong Chen, Xue-Qing Li, Fei Ding, Rui-Qin Zhong
Chem. Eur. J. 2004, 10, 3685 -3696,-0001,():
-1年11月30日
A series of bridged β-cyclo- dextrin(β-CyD) dimers possessing functional tethers of various lengths was synthesized in moderate yield by the treatment of 2,2’-biquinoline- 4,4’-dicarboxylic dichloride with β-CyD or mono[6-oligo(ethylenediamino)-6- deoxy]-β-CyDs. The products were 2,2’-biquinoline-4,4’-dicarboxy-bridged bis(6-O-β-CyD)(8), N,N’-bis(2-amino- ethyl)-2,2’-biquinoline-4,4’-dicarbox- amide-bridged bis(6-amino-6-deoxy-β- CyD)(9), and N,N’-bis(5-amino-3-aza- pentyl)-2,2’-biquinoline-4,4’-dicarbox- amide-bridged bis(6-amino-6-deoxy-β- CyD)(10). The reaction of 8-10 with copper perchlorate give their copper(II) complexes 11-13 in satisfactory yields of over 77%. All the bis(β-CyD)s 8-13 act as efficient fluorescent sensors and display remarkable fluorescence enhancement upon addition of optically inert steroids. The inclusion complexa- tion behaviors of 8-13 when treated with the representative steroids cholate(14), deoxycholate(15), and glycocho- late(16) in aqueous solution at 25℃ were investigated by means of UV/Vis spectroscopy, conductivity and fluorescence measurements, circular dichroism spectroscopy, and 2D NMR spectroscopy. The tether length of bis(β-CyD) 9 allows it to adopt a cooperative host-tether-guest binding mode in which the spacer and guest are co-included in the two CyD cavities. As a result of this cooperation, 9 has a stability constant[Ks] about 2×102 times higher than that of monomodified β-CyD 4 for inclusion complexation with cholate. Metallooligo(β-CyD)s with four β- CyD units have enhanced binding abilities compared with monomodified β-CyDs. These metallo compounds have binding affinities for guest steroids that are up to 50-4.1 ×103 times higher than those of CyDs 2-4. The guest-induced fluorescence enhancement of bis(CyD)s opens a new channel for the design of sensor materials. The complex stability constants of these compounds are discussed from the viewpoint of induced-fit interaction and cooperative multiple binding between host and guest.
cyclodextrins, fluorescent sensors, molecular recognition, steroids, supramolecular chemistry
-
40浏览
-
0点赞
-
0收藏
-
0分享
-
204下载
-
0评论
-
引用
宋芸, Yu Liu, Ying-Wei Yang, Yun Song, Heng- Yi Zhang, Fei Ding, Takehiko Wada, Yoshihisa Inoue
Chem Bio Chem 2004, 5, 868 -871 ,-0001,():
-1年11月30日
binding, cyclodextrins, peptides, recognition
-
32浏览
-
0点赞
-
0收藏
-
0分享
-
114下载
-
0评论
-
引用
宋芸, Yu Liu, Yun Song, Hao Wang, Heng-Yi Zhang, Xue-Qing Li
Macromolecules 2004, 37, 6370-6375,-0001,():
-1年11月30日
Bis(polypseudorotaxane)s possessing the bridged bis(β-cyclodextrin)s with multi coordinated metal centers are prepared, in which β-cyclodextrin (β-CD) acts as the host structure, amino-terminated polypropylene glycol(PPG; MW=2000) as the guest, and nickel(II) complexes as templating moieties. The assembly behavior is comprehensively studied by NMR spectroscopy, gel permeation chromatography(GPC), end group assay, static light scattering, thermogravimetric(tG), differential thermal analysis(dTA), and scanning tunneling microscopy(STM). The obtained results indicate that not only could the two PPG molecules be respectively threaded into metallo-bridged bis(β-CD)s forming the double-strand structure, but they also could play a stabilizing role in the molecular aggregation. The fluorescence titrations are performed in a mixture of acetonitrile/water to calculate the effective binding constants and thermodynamic parameters for the threading process of 2 onto PPG. The results reveal that the assembly process as being driven by favorable entropic contributions accompanying a large positive enthalpic change. The present investigations provide a simple way to prepare multicomponent nanometer-scale organic supermolecules with multiple CD dimers coordinated metal centers.
-
131浏览
-
0点赞
-
0收藏
-
0分享
-
132下载
-
0评论
-
引用
宋芸, Yu Liu, Yun Song, Yong Chen, Zi-Xin Yang, Fei Ding
J. Phys. Chem. B 2005, 109, 10717-10726,-0001,():
-1年11月30日
A series of β-cyclodextrin(β-CD) dimers with 4,4′-diselenobis(benzoyl) linkers, that is, 6,6′-[4,4′-diselenobis-(benzoyloxyl)]-bridged bis(β-CD)(1a), 6,6′-[4,4′-diselenobis(2-(benzoylamino)ethyleneamino)]-bridged bis(β-CD)(2a), and 6,6′-[4,4′-diselenobis(2-(benzoylamino)-3,6-diazaoctylamino)]-bridged bis(β-CD)(3a), were synthesized in moderate yields by the reaction of 4,4′-diselenobis(benzoic acid] with β-CD or oligo(ethylenediamino)-6-deoxy-β-CD. Their binding behaviors with some structure-related substrates, such as acridine red(AR), neutral red(NR), rhodamine B(RhB), ammonium 8-anilino-1-naphthalenesulfonate(ANS), and 6-p-toluidino-2-naphthalenesulfonic acid(tNS), were investigated in aqueous phosphate buffer solution(pH 7.20) at 298.15 K by means of fluorescence, NMR, as well as circular dichroism spectroscopy and compared with those of their 2,2′-diselenobis(benzoyl)-linked analogues, that is, 6,6′-[2,2′-diselenobis-(benzoyloxyl)]-bridged bis(β-CD)(1b), 6,6′-[2,3′-diselenobis(2-(benzoylamino)ethyleneamino)]-bridged bis-(β-CD)(2b), and 6,6′-[2,2′-diselenobis(2-(benzoylamino)-3,6-diazaoctylamino)]-bridged bis(β-CD)(3b). The results showed that bis(β-CD)s 1a-3a, whose Se-Se bonds were located at the para position of the carboxyl group, gave stronger binding abilities toward nonlinear guests(RhB and ANS) than their analogues 1b-3b, whose Se-Se bonds were located at the ortho position relative to the carboxyl group. The molecular binding ability and selectivity of model substrates by these ditopic hosts were sufficiently discussed to reveal not only the cooperative contributions of the linker group and CD cavities upon inclusion complexation with dye guest molecules but also the controlling factors for the molecular selective binding.
-
35浏览
-
0点赞
-
0收藏
-
0分享
-
158下载
-
0评论
-
引用
宋芸, Yun Song, Yong Chen, Yu Liu
Journal of Photochemistry and Photobiology A: Chemistry 173(2005) 328–333,-0001,():
-1年11月30日
An xanthene dye, pyronine Y, was found to exhibit opposite fluorescence behaviors at different pH values in the presence of N,N’-bis(2- aminoethyl)-2,2’-biquinoline-4,4’-dicarboxamide-bridged bis(β-cyclodextrin)(2). That is, pyronine Y showed the quenched fluorescence in an acidic(pH 2.0) or a neutral(pH 7.2) environment, while the enhanced fluorescence in a basic environment(pH 12.0), with the addition of 2. Further studies by fluorescence titrations and 2D NMR indicated that different binding modes of positively charged and neutral PY molecules upon complexation with bis(β-cyclodextrin) 2 should be responsible for opposite fluorescence behaviors. This result may enable the biquinolino-bridged bis(β-cyclodextrin) as an efficient chemical sensor for the protonation and deprotonation of xanthene dyes.
Spectrophotometric titration, Cyclodextrin, Pyronine Y, Fluorescence sensing, Photoinduced electron transfer
-
33浏览
-
0点赞
-
0收藏
-
0分享
-
145下载
-
0评论
-
引用
宋芸, 刘育
化学学报2005年第63卷第2期,103~108/ ACTA CHIMICA SINICA Vol.63, 2005, No.2, 103~108,-0001,():
-1年11月30日
采用荧光光谱滴定的方法测定了一系列联喹啉桥联双环糊精在磷酸缓冲溶液中(25℃,pH=7.2)与几种染料客体分子形成化学计量比为1∶1的超分子配合物的稳定常数。结果表明,拥有刚性和大π电子体系的联喹啉桥联双环糊精比相应的联吡啶桥联双环糊精对三角形的RhB分子和线形的AR分子具有更强的分子键合能力。二维核磁的研究证实,桥联双环糊精对客体分子强的键合能力起源于在一个分子内两个环糊精单元的协同键合。桥联双环糊精对染料客体分子的选择键合能力从主-客体间的尺寸/形状匹配以及几种弱相互作用力的协同效应进行了讨论。
桥联双环糊精, 荧光滴定法, 分子识别, 染料, 超分子化学
-
37浏览
-
0点赞
-
0收藏
-
0分享
-
133下载
-
0评论
-
引用
宋芸, Yu Liu, Li Li, Heng-Yi Zhang, Yun Song
J. Org. Chem., Vol. 68, No. 2, 2003,-0001,():
-1年11月30日
To investigate quantitatively the cooperative binding ability of β-cyclodextrin dimers, a series of bridged bis(β-cyclodextrin)s with 2,2′-diselenobis(benzoyl) spacer connected by different lengths of oligo(ethylenediamine)s(2-5) and their platinum(IV) complexes(6-9) have been synthesized and their inclusion complexation behavior with selected substrates, such as Acridine Red, Neutral Red, Brilliant Green, Rhodamine B, ammonium 8-anilino-1-naphthalenesulfonate, and 6-p-toluidino-2- naphthalenesulfonic acid, were investigated by means of ultraviolet, fluorescence, fluorescence lifetime, circular dichroism, and 2D-NMR spectroscopy. The spectral titrations have been performed in aqueous phosphate buffer solution(pH 7.20) at 25°C to give the complex stability constants(KS) and Gibbs free energy changes(-ΔG°) for the inclusion complexation of hosts 2-9 with organic dyes and other thermodynamic parameters(ΔH° and TΔS°) for the inclusion complexation of 2-5 with fluorescent dyes ANS and TNS. The results obtained indicate that β-cyclodextrin dimers 2-5 can coordinate with one or two platinum(IV) ions to form 1:1 or 1:2 stoichiometry metallobridged bis(β-cyclodextrin)s. As compared with parent β-cyclodextrin(1) and bis(β-cyclodextrin)s 2-5, metallobridged bis(β-cyclodextrin)s 6-9 can further switch the original molecular binding ability through the coordinating metal to orientate two β-cyclodextrin cavities and an additional binding site upon the inclusion complexation with model substrates, giving the enhanced binding constants KS for both ANS and TNS. The tether length between two cyclodextrin units plays a crucial role in the molecular recognition with guest dyes. The binding constants for TNS decrease linearly with an increase in the tether length of dimeric β-cyclodextrins. The Gibbs free energy change(-ΔG°) for the unit increment per ethylene is 0.32 kJ mol 1 for TNS. Thermodynamically, the higher complex stabilities of both ANS and TNS upon the inclusion complexation with 2-5 are mainly contributed to the favorable enthalpic gain(-ΔH°) by the cooperative binding of one guest molecule in the closely located two β-cyclodextrin cavities as compared with parent β-cyclodextrin. The molecular binding ability and selectivity of organic dyes by hosts 1-9 are discussed from the viewpoints of the multiple recognition mechanism and the size/shape-fitting relationship between host and guest.
-
38浏览
-
0点赞
-
0收藏
-
0分享
-
173下载
-
0评论
-
引用
宋芸, Yu Liu, Hao Wang, Heng-Yi Zhang, Li-Hua Wang, Yun Song
Chemistry Letters Vol.32, No.10(2003),-0001,():
-1年11月30日
Studies on linear aggregation prepared by inclusion complexation of bridged bis(β-cyclodextrin)s and calix[4]arene derivatives provide a simple method to control linear aggregation compactness by molecular recognition.
-
24浏览
-
0点赞
-
0收藏
-
0分享
-
98下载
-
0评论
-
引用
【期刊论文】Synthesis of Phosphane Oxide Bridged Bis-and Triscatechol Derivatives
宋芸, Markus Albrecht, Yun Song,
SYNTHESIS 2006, No. 18, pp 3037–3042,-0001,():
-1年11月30日
Linear biscatechols and triangular triscatechols possessing spacers containing phosphane oxide were synthesized. For this, the central phosphorus was introduced by the reaction of active organometallic intermediates with either dichlorophenylphosphane or phosphorus trichloride/phosphoryl chloride. In the final steps, the methyl ethers at the veratrol units were cleaved by boron tribromide to afford the free phosphane oxide catechol derivatives, which in metal-directed self-assembly processes would lead to helical or tetrahedral supramolecular aggregates.
phosphane oxide, amides, catechol, ligands, Suzuki coupling
-
38浏览
-
0点赞
-
0收藏
-
0分享
-
258下载
-
0评论
-
引用