蓝闽波
从事有机功能性材料的分子定量构效关系研究;设计、合成了数种新型EPR氧生物医学传感器材料;建立了高敏感度的活体在线氧自由基分析法。近年来,研究领域扩展到植物抗氧化的筛选和发现。
个性化签名
- 姓名:蓝闽波
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
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学科领域:
分析化学
- 研究兴趣:从事有机功能性材料的分子定量构效关系研究;设计、合成了数种新型EPR氧生物医学传感器材料;建立了高敏感度的活体在线氧自由基分析法。近年来,研究领域扩展到植物抗氧化的筛选和发现。
蓝闽波:教授,博士,华东理工大学教授,兼上海市纳米科技首席科学家,“Advanced Science Letter” Associate Editor,以及华东理工大学学报、中国体育运动材料和国际Nanoscience编委。教育部跨世纪优秀人才(2001)。华东理工大学实验室与装备处处长,分析测试中心主任。
1983年在华东理工大学获化学工程学士学位;1993年在华东理工大学获博士学位。1996年短期赴日本食品综合技术研究所从事植物蛋白结构分析和模拟生物膜研究,1997年受日本科技厅邀请,赴日本电子综合技术研究所担任科技厅特别研究员,从事具有纳米材料的有机超薄膜结构和性能的研究。2000年受美国卫生研究院(NIH Fellow)资助,赴比利时鲁汶大学医学院从事EPR氧生物传感器的研究。 2001.5回国,返回华东理工大学继续从事功能性材料和生物传感器研究。多年来,一直从事有机功能性材料的分子定量构效关系研究;设计、合成了数种新型EPR氧生物医学传感器材料;建立了高敏感度的活体在线氧自由基分析法。近年来,研究领域扩展到植物抗氧化的筛选和发现。
近年来,在Magnetic Resonance in Medicine等国内外核心刊物发表系列学术论文60多篇,发明专利10项。先后承担欧盟第六框架计划项目(NACBO)、国家自然科学基金及国家攻关项目。先后获省部级科技进步奖二等奖1项、三等奖3项。
十年来,主要从事的研究工作包括有机功能性材料的研制,涉及光电和生物材料领域,有机超薄膜的研制和理论研究。近年从事生物医学传感器的材料试制和器件开发研究工作,以及植物药物的发现,培养博士,硕士研究生十多名。
目前担任上海市纳米材料检测中心科技委副主任,理事、上海市纳米紧缺人才培训计划专家委员会副主任、中韩纳米基金专家委员会副主任和国家实验室认可委员会化学委员会委员。上海市中医药大学兼职博导。
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20
【期刊论文】A Novel Dual-Layer Dye photoreceptor
蓝闽波, Minbo Lan, Shengwu Ren, Yanqiao Wang, Jiabai Qiu & Xurui Xiao
Dyes and Pigments, Vol. 38, Nos. 1-3, pp.107-113, 1998,-0001,():
-1年11月30日
The xerographic properties of dual-layer photoreceptors having different molecular structure, are described with respect to their photosensitivities. A correlation between the absorption wavelength and the photosensitivity was found. A study on device optimization of 3,4,9,10-perylenetetracarboxylic diimides was carried out. The dual-layer photoreceptor device exhibited low dark decay and flat spectral response from 450-750 nm. The spectral sensitivity of the dual-layer photoreceptor extends to the near-IR region.
3,, 4,, 9,, 10-perylenetetracarboxylic diimides, phthalocyanines, organic photoconductors
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蓝闽波, Ying Wu, , Lede Miao, Huihui Yuan, Shaohua Zuo, Changming Ding, and Minbo Lan
Chemistry Letters Vol. 35, No. 7(2006),-0001,():
-1年11月30日
A newly synthesized nitroxide radical,4-ferrocenecarboxyI-2,2,6,6-tetramethyI piperidine-1-oxyl(FC-TEMPO), was firstly encapsulated in the poly(DL-Lactic acid) (PLA) nanoparticles by the modified spontancous emulsification solvent diffusion method. The formation of the nanoparticles with diameters of 120
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【期刊论文】Absorption and EPR spectra of some porphyrins and metalloporphyrins
蓝闽波, Minbo Lan, , Hongli Zhao, Huihui Yuan, Chengrui Jiang, Shaohua Zuo, Ying Jiang
Dyes and Pigments 74(2007)357-362,-0001,():
-1年11月30日
Novel smart materials can be synthesized and designed at the molecular level by attaching well characterized and tailored functionalities to be used in in vitro and in vivo oximetry. A series of porphyrins and metalloporphyrins were synthesized and their EPR and UV-vis spectra studied. The steric hindrance and electronic effects of the substituted groups and the characteristics of different metal ions were the major contributors in influencing the properties of the compounds. As a result, their EPR and UV-vis spectra changed. Through studying the EPR spectroscopic properties of these compounds, we hope that novel EPR oximetry materials can be found and this will help to extend the applications of EPR oximetry in vivo.
EPR and UV-vis spectra, Porphyrins, Metalloporphyrins
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【期刊论文】Carbon Blacks as EPR Sensors for Localized Measurements of Tissue Oxygenation
蓝闽波, Minbo Lan, Nelson Beghein, Nicolas Charlier, and Bernard Gallez
Magnetic Resonance in Medicine 51: 1272-1278(2004),-0001,():
-1年11月30日
New electron paramagnetic resonance (EPR) oximetry probes were identified in the class of carbon black materials. These compounds exhibit very high oxygen sensitivity and favorable EPR characteristics for biological applications. At low pO2, the linewidth is particularly sensitive to changes in oxygen tension (sensitivity of 750 mG/mmHg). The application of the probes for oximetry was demonstrated in vivo: the pO2 was measured in muscle in which the blood flow was temporarily restricted as well as in tumor-bearing mice during a carbogen breathing challenge. The responsiveness to pO2 was stable in muscle for at least 3 months. No toxicity was observed using these materials in cellular experiments and in histological studies performed 2, 7, and 28 days after implantation. In view of their EPR characteristics (high sensitivity) as well as the well-characterized production procedure that make them available on a large scale, these probes can be considered as very promising tools for future developments in EPR oximetry. Magn Reson Med 51:1272-1278, 2004.
EPR oximetry, carbon, oxygenation, vivo, free radicals
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蓝闽波, Y.Wu, Tang, C.L.L, J.W.Liu, L.D.Miao, J. Han, M.B.Lan
Pharmazie 61(2006)12,-0001,():
-1年11月30日
Low molecular weight nitroxides are widely used as electron paramagentic resonance(EPR)-detectable spin labels in the biological and pathological areas. A novel nitroxide derivative, 4-ferrocenecarboxyl-2,2,6,6-tetramethyl piperidine-1-oxyl(FC-TEMPO), was synthesized for evaluating the effects of spin label compounds on tumor cells and firstly its biological effects on tumor and normal cells were evaluated. The cytotoxicity of FC-TEMPO in the hige metastatic lung carcinoma cells(95-D) showed that it markedly inhibited the viabillity of cancer cells in a dose-dependent manner, while it was less toxic to a normal human cell line. Further studies found that FC-TEMPO suppressed the growth of tumor cells by induced apoptosis through activating caspase-3 but not caspase-8 which was proved by caspase inhibitors, and the cell cycle arrest at G; phase. Moreover, the concomitant increase of superoxide dismutase(SOD) and catalase (CAT) activity was boserved. Taken together, these resluts right provide a base for further anticancer investigations of nitroxides and their potential pharmacologicalapplications
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蓝闽波, Keiichi Ikegami, Christophe Mingotaud, Minbo Lan,
Thin Solid Films 393(2001)193-198,-0001,():
-1年11月30日
Anisotropic visible and infrared(IR).absorption spectra of Langmuir-Blodgett(LB).films of mutually mixed merocyanine dyes deposited with Cd2+ ions were recorded. In these films, a merocyanine dye ‘DO’ is included in J-aggregates, although in LB films of DO(not mixed with other merocyanine dyes), DO itself does not form J-aggregates. A difference spectrum method successfully separated the spectra observed into two components, one of which was due to J-aggregates. This component includes the contribution of the J-aggregated DO molecules and compared well with the absorption spectra observed for LB films of DO. This comparison detected, for the aggregated DO, red shifts of several IR bands due to softening of the bond alternation in the central conjugated system of the molecule, which thus suggested that intramolecular charge transfer is enhanced by the formation of J-aggregates.
Polarized absorption spectroscopy, UV-visible spectroscopy, FT-IR spectroscopy, J-aggregates, Merocyanine dyes, Langmuir-Blodgett films
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【期刊论文】IR studies on J-aggregates in Langmuir-Blodgett films of mutually mixed merocyanine dyes
蓝闽波, Minbo Lan, , Keiichi Ikegami
Thin Solid Films 384(2001)120-124,-0001,():
-1年11月30日
J-aggregates in LangmuirBlodgett (LB). films of mutually mixed merocyanine dyes were characterized by using Fourier transform infrared(FT-IR).spectroscopy. Two merocyanine dyes, one which forms and one which does not form J-aggregates in their LB films with fatty acids and divalent metals, so-called 6MeDS and DO, respectively, were used in this study. In LB films of DO-6MeDS mutual mixtures, most DO molecules are included in J-aggregates. The IR spectra of these films were measured and compared with linear combinations of the spectra for DO and 6MeDS films. The difference between the measured and the calculated IR spectra reflects the difference between the electronic state of J-aggregated DO and that of monomeric DO. The results suggest an enhancement of the intramolecular charge transfer induced by the formation of J-aggregates.
Langmuir-Blodgett films, Infrared spectroscopy, J-aggregation, Organic dyes
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蓝闽波, Keiichi Ikegami, Christophe Mingotaud, and Minbo Lan
J. Phys. Chem. B 1999, 103, 11261-11268,-0001,():
-1年11月30日
Langmuir-Blodgett films of mixtures of fatty acids (FA) and a merocyanine dye (DS), bearing one long alkyl chain and one carboxylic group, were prepared at a nitrogen-pure water interface. The films exhibit a distinct and highly anisotropic J-band near 605 nm, even though they do not contain any metallic or ammonium cations. Although an isotropic band was seen in the region of 500-550 nm, the contribution of the J-aggregates was extracted from the observed visible and IR absorption spectra by using the difference in the polarization of the bands. This analysis indicates a change in the electronic structure of DS in the J-aggregates, probably corresponding to intramolecular charge transfer. Furthermore, this analysis also suggests that in this metalfree case, the formation of the J-aggregates is strongly affected by the hydrogen bonding between the carboxylic groups in two DS and that between the carboxylic groups in DS and FA.
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【期刊论文】Mixing characterization of perylene and merocyanine Langmuir-Blodgett films
蓝闽波, Minbo Lan, , Keiichi Ikegami
Colloids and Surfaces A: Physivovhem. Eng. Aspects 257-258(2005)225-229,-0001,():
-1年11月30日
Langmuir–Blodgett (LB) films of mixtures of 3,4,9,10-perylenetetracarboxylic diimide (PTCDI), merocyanine dye (DO) and arachidic acid(C20) with different molecular ratios, were prepared on Cd2+-containing and pure-water subphases. The characterization of mixed Langmuir and LB films were performed by using, respectively, surface pressure-molecular area isothermetry and UV-Vis-IR absorption spectroscopy. The analysis indicates that interaction between the two dyes modifies their arrangements and electronic states in their mixed Langmuir films spread upon the Cd2+-containing subphase. However, the mixed LB films with the pure-water subphase are showed to be simple physical mixtures. The difference in the mixing effect observed for the Langmuir films upon the Cd-containing and pure-water subphases may be caused by the formation of metal chelation with the former subphase.
Merocyanine dyes, Perylenetetracarbolic diimide, Langmuir-Blodgett films, Infrared spectroscopy, Intermolecular interaction
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【期刊论文】Molecular Orientation of Langmuir-Blodgett Films of AlkyIDCNQI-Cu and AlkyIRCNQ-Cu Complexes
蓝闽波, Keiichi Ikegamei, Tapas Pal Majumder, , Minbo Lan, and Takayoshi Nakamura
Transactions of the Materials Research Society of Japan 28[1]51-54(2003),-0001,():
-1年11月30日
LB films of organic-inorganic charge-transfer systems, Cu-complexes of 2-methyl-5-octadecyIDCNQI(C18MeDCNQI) and 2-alkylTCNQ(CnTCNQ with n=12,15 and 18), were successfully fabricated by utillizing the airwater interface as a reaction field for the reduction of the acceptor moieties. The charge transfer degrees of the C18MeDCNQI and CnTCNQ in the LB films were estimated at -1, respectively, from the changes in their IR absorption spectra upon the reduction. The molecular orientation in the films were discussed on the basis of polarized IR spectroscopy. It is suggested that the molecular orientation in the present LB films is largely affected by the coordinate bonds between the Cu cations and the cyanic groups.
Langmuir-Blodgett films, molecular orientation, charge-transfer complex, FT-IR
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